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Registry of Toxic Effects of Chemical Substances (RTECS)

Guanidine, monohydrochloride

RTECS #

MF4300000

CAS #

50-01-1

Updated

December 2010

Molecular Weight

95.55

Molecular Formula

CH5N3·ClH

Synonyms

Aminoformamidine hydrochloride
Aminomethanamidine hydrochloride
Carbamidine hydrochloride
Guanidine chloride
Guanidine hydrochloride
Guanidinium chloride
Guanidinium hydrochloride
Iminourea hydrochloride
USAF EK-749

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 81400 µg moderateNTIS** AD-A184-068
skin /rabbit 500 mg/24H severeNTIS** AD-A166-306

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Saccharomyes cerevisiae4 mmol/L (-enzymatic activation step)BBRCA9 53,531,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraarterial/guinea pig lowest published lethal dose: 500 mg/kgAEPPAE 131,171,1928
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgNTIS** AD277-689
intravenous/guinea pig lowest published lethal dose: 500 mg/kgAEPPAE 131,171,1928
oral/mammal (species unspecified) lowest published lethal dose: 300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
JIDHAN 13,87,1931
oral/mouse lethal dose (50 percent kill): 571 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability
ATDAEI 12,598,1993
oral/rat lethal dose (50 percent kill): 475 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea
NTIS** AD-A165-747
oral/rat lethal dose (50 percent kill): 800 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Other changes
TOVEFN (6),34,2004
skin/rabbit Lethal dose: >2 gm/kgATDAEI 12,596,1993
subcutaneous/Dog lowest published lethal dose: 200 mg/kgHBAMAK 4,1352,1935
subcutaneous/guinea pig lowest published lethal dose: 100 mg/kgHBAMAK 4,1352,1935
subcutaneous/rat lowest published lethal dose: 404 mg/kgJPETAB 28,251,1926

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3755; Number of Industries 2; Total Number of Facilities 115; Number of Occupations 22; Total Number of Employees Exposed 2097; Total Number of Female Employees Exposed 589

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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