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Guanidine, monohydrochloride

RTECS #: MF4300000

CAS #: 50-01-1


UPDATE: January 1997 MW: 95.55 MF: CH5N3•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Aminoformamidine hydrochloride
  2. Aminomethanamidine hydrochloride
  3. Carbamidine hydrochloride
  4. Guanidine chloride
  5. Guanidine hydrochloride
  1. Guanidinium chloride
  2. Guanidinium hydrochloride
  3. Iminourea hydrochloride
  4. USAF EK - 749


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
81,400 µg moderate NTIS** AD-A184-068
skin
rabbit
500 mg/24 hour severe NTIS** AD-A166-306


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 4 mmol/L (-enzymatic activation step) BBRCA9 53,531,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraarterial
guinea pig
lowest published lethal dose: 500 mg/kg N/R AEPPAE 131,171,1928
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
intravenous
guinea pig
lowest published lethal dose: 500 mg/kg N/R AEPPAE 131,171,1928
oral
mammal (species unspecified)
lowest published lethal dose: 300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
JIDHAN 13,87,1931
oral
mouse
lethal dose (50 percent kill): 571 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability
ATDAEI 12,598,1993
oral
rat
lethal dose (50 percent kill): 475 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea
NTIS** AD-A165-747
subcutaneous
dog
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1352,1935
subcutaneous
guinea pig
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1352,1935
subcutaneous
rat
lowest published lethal dose: 404 mg/kg N/R JPETAB 28,251,1926
skin
rabbit
lethal dose : >2 gm/kg N/R ATDAEI 12,596,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3755;
Number of Industries 2;
Total Number of Facilities 115;
Number of Occupations 22;
Total Number of Employees Exposed 2,097;
Total Number of Female Employees Exposed 589


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

FDA-proprietary drug

RTECS Compound Description:
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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