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Registry of Toxic Effects of Chemical Substances (RTECS)

Guanidine, cyano-

RTECS #

ME9950000

CAS #

461-58-5

Updated

February 2007

Molecular Weight

84.10

Molecular Formula

C2H4N4

Synonyms

1-Cyanoguanidine
ACR-H 3636
Araldite HT 986
Araldite XB 2879B
Araldite XB 2979B
Bakelite VE 2560
Cyanoguanidine
Dicyandiamide
Dicyandiamin (German)
Dicyanodiamide
Epicure DICY 15
Epicure DICY 7
N-Cyanoguanidine
XB 2879B

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intradermal/guinea pig lowest published toxic dose: 200 µg/kgImmunological Including Allergic: Increase in cellular immune responseTOVEFN (4),40,1998
intraperitoneal/mouse lethal dose (50 percent kill): >4 gm/kgAPTOA6 8,329,1952
intraperitoneal/rabbit lethal dose (50 percent kill): >3 gm/kgAPTOA6 8,329,1952
oral/mouse lethal dose (50 percent kill): >10000 mg/kgTOVEFN (4),40,1998
oral/rat lethal dose (50 percent kill): >20000 mg/kgTOVEFN (4),40,1998
oral/rat Lethal dose: >500 mg/kgNCNSA6 5,17,1953
unreported route/rat lowest published lethal dose: 600 mg/kgBCPCA6 14,1325,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 2400 µg/m3/4W- intermittentBlood: Other changesTOVEFN (4),39,1998
inhalation/guinea pig lowest published toxic concentration: 2.4 mg/m3/4W- intermittentBlood: Eosinophilia

Immunological Including Allergic: Increase in cellular immune response
TOVEFN (4),40,1998
inhalation/rat lowest published toxic concentration: 2.4 mg/m3/4W- intermittentBlood: Eosinophilia

Immunological Including Allergic: Increase in cellular immune response
TOVEFN (4),40,1998
inhalation/rat lowest published toxic concentration: 2400 µg/m3/4W- intermittentBlood: Other changesTOVEFN (4),39,1998
oral/rat lowest published toxic dose: 273 gm/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (109),61,1991

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83038; Number of Industries 48; Total Number of Facilities 1639; Number of Occupations 50; Total Number of Employees Exposed 35475; Total Number of Female Employees Exposed 7043
National Occupational Hazard Survey 1974Hazard Code 83038; Number of Industries 27; Total Number of Facilities 720; Number of Occupations 55; Total Number of Employees Exposed 19281

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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