Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Glycolic acid

RTECS #

MC5250000

CAS #

79-14-1

Updated

January 2010

Molecular Weight

76.06

Molecular Formula

C2H4O3

Synonyms

2-Hydroxyacetic acid
Acetic acid, hydroxy-
alpha-Hydroxyacetic acid
Hydroxyacetic acid
Hydroxyethanoic acid
Kyselina glykolova (Czech)
Kyselina hydroxyoctova (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 2 mg severeAJOPAA 29,1363,1946
eye /rabbit 0.1 mL severeHPV251 -,-,2001
skin /human 50%HPV251 -,-,2001
skin /rabbit 0.5 mL severeHPV251 -,-,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 9 gm/kg (7-12D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 53,117,1996
oral/rat 5250 mg/kg (7-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)DCTODJ 22,569,1999
oral/rat 4500 mg/kg (7-21D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV251 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 7.1 gm/m3/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 9,435,1997
inhalation/rat lethal concentration (50 percent kill): 3600 mg/m3/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV251 -,-,2001
intravenous/cat lethal dose (50 percent kill): 1 gm/kg85JCAE -,656,1986
oral/guinea pig lethal dose (50 percent kill): 1920 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/rat lethal dose (50 percent kill): 1938 mg/kgGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV251 -,-,2001
oral/rat lethal dose (50 percent kill): 1950 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 gm/m3/6H/2W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0546415
inhalation/rat lowest published toxic concentration: 500 mg/m3/2W- intermittentLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HPV251 -,-,2001
inhalation/rat lowest published toxic concentration: 1000 mg/m3/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV251 -,-,2001
oral/cat lowest published toxic dose: 970 mg/kg/7D- intermittentBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 34,86,1944
oral/rat lowest published toxic dose: 27000 mg/kg/90D- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV251 -,-,2001
oral/rat lowest published toxic dose: 27000 mg/kg/90D- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV251 -,-,2001
oral/rat lowest published toxic dose: 2480 gm/kg/35W- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ABBIA4 84,183,1959
oral/rat lowest published toxic dose: 52500 mg/kg/3W- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
INURAQ 13,113,1975

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,314,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 35260; Number of Industries 64; Total Number of Facilities 5782; Number of Occupations 63; Total Number of Employees Exposed 191563; Total Number of Female Employees Exposed 98538
National Occupational Hazard Survey 1974Hazard Code 35260; Number of Industries 27; Total Number of Facilities 2991; Number of Occupations 29; Total Number of Employees Exposed 29291

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
TOP