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Glycine, N - (phosphonomethyl) -

RTECS #: MC1075000

CAS #: 1071-83-6

UPDATE: May 2009 MW: 169.09 MF: C3H8NO5P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Accord
  2. Glifinox
  3. Gliialka
  4. Glyphosate
  5. MON 0573
  1. MON 2139
  2. N - (Phosphonomethyl) glycine
  3. Rodeo
  4. Sonic
  5. Tornado


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis cattle lymphocyte 17 µmol/L MUREAV 403,13,1998
DNA damage hamster ovary 5.5 mmol/L EMMUEG 44,179,2004
DNA damage human fibroblast 75 mmol/L/1 hour TOLED5 147,35,2004
DNA damage human other cell types 5.25 mmol/L EMMUEG 44,179,2004
other mutation test systems cattle lymphocyte 17 µmol/L MUREAV 403,13,1998
sister chromatid exchange cattle lymphocyte 17 µmol/L MUREAV 403,13,1998
specific locus test Drosophila melanogaster 2 mmol/L EMMUEG 36,40,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 49 gm/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TJADAB 61,446,2000
oral
rat 		lowest published toxic dose: 30 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system FEREAC 69,51301,2004
unreported route
mammal (species unspecified) 		lowest published toxic dose: 30 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system FEREAC 63,54060,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >12,200 mg/m3/4 hour N/R 85JFAN A222,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 130 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase 		TOLED5 1000(Sp Iss 1),148,1980
intraperitoneal
rat 		lethal dose (50 percent kill): 235 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase 		TOLED5 1000(Sp Iss 1),148,1980
multiple
non-mammalian species 		lethal dose (50 percent kill): 0.59 gm/m3/24 hour N/R TOVEFN (6),40,2003
oral
human 		lowest published toxic dose: 1.67 mL/kg Cardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed 		AJEMEN 26,275,2008
oral
human 		lowest published lethal dose: 1.84 mL/kg Cardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed 		AJEMEN 26,275,2008
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 69,51301,2004
oral
man 		lowest published lethal dose: 2,143 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Fibrosing alveolitis 		JTCTDW 29,91,1991
oral
man 		lowest published toxic dose: 1,214 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Hypermotility, diarrhea 		HETOEA 10,103,1991
oral
mouse 		lethal dose (50 percent kill): 1,568 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase 		TXAPA9 45,319,1978
oral
mouse 		lethal dose (50 percent kill): 2,160 mg/kg N/R MUTAEX 21,375,2006
oral
quail 		lethal dose (50 percent kill): >4,640 mg/kg N/R PEMNDP 9,459,1991
oral
rat 		lethal dose (50 percent kill): 4,873 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase 		TXAPA9 45,319,1978
oral
rat 		lethal dose (50 percent kill): 5,000 mg/kg N/R FEREAC 63,54059,1998
oral
rabbit 		lethal dose (50 percent kill): 3,800 mg/kg N/R PESTC* 7,6,1978
oral
woman 		lowest published lethal dose: 4 gm/kg Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		JTCTDW 29,91,1991
skin
mammal (species unspecified) 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 69,51301,2004
skin
rabbit 		lethal dose (50 percent kill): 2,000 mg/kg N/R FEREAC 63,54060,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
multiple
non-mammalian species 		lowest published toxic dose: 0.53 gm/m3/2 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOVEFN (6),40,2003
multiple
non-mammalian species 		lowest published toxic dose: 0.33 gm/m3/21 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOVEFN (6),40,2003
multiple
non-mammalian species 		lowest published toxic dose: 0.26 gm/m3/21 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOVEFN (6),40,2003
oral
mouse 		lowest published toxic dose: 435 gm/kg/13 week- continuous Gastrointestinal: Changes in structure or function of salivary glands

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-92-3135
oral
mouse 		lowest published toxic dose: 405,000 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,51301,2004
oral
non-mammalian species 		lowest published toxic dose: 75 mg/kg/15 day- intermittent Endocrine: Androgenic

Endocrine: Estrogenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		REPTED 23,182,2007
oral
non-mammalian species 		lowest published toxic dose: 75 mg/kg/15 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		REPTED 23,182,2007
oral
rat 		lowest published toxic dose: 153 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTPTR* NIH-92-3135
oral
rat 		lowest published toxic dose: 22,500 mg/kg/90 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea 		HCKHDV 5(2),52,1984
oral
rat 		lowest published toxic dose: 49,000 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TJADAB 61,446,2000
oral
rat 		lowest published toxic dose: 420 mg/kg/21 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight 		REPTED 19,501,2005
oral
rat 		lowest published toxic dose: 420 mg/kg/21 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 19,501,2005
oral
rat 		lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Changes in: P

Nutritional and Gross Metabolic: Changes in: K 		FEREAC 69,51301,2004
oral
rat 		lowest published toxic dose: 375 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TOXID9 12,471,2008
skin
rabbit 		lowest published toxic dose: 105,000 mg/kg/21 day- intermittent Skin: After systemic exposure: Dermatitis, irritative FEREAC 67,60934,2002
skin
rabbit 		lowest published toxic dose: 105,000 mg/kg/21 day- intermittent Behavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, irritative 		FEREAC 67,60934,2002
skin
rabbit 		lowest published toxic dose: 105,000 mg/kg/21 day- intermittent Skin: After topical application: Primary irritation FEREAC 69,51301,2004
skin
rabbit 		lowest published toxic dose: 105,000 mg/kg/21 day- intermittent Behavioral: Food intake (animal)

Skin: After topical application: Primary irritation 		FEREAC 69,51301,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,455,2005
TOXICOLOGY REVIEW
JTEHD6 7,267,2004
TOXICOLOGY REVIEW
FEREAC 71,32899,2006
TOXICOLOGY REVIEW
FEREAC 71,56392,2006
TOXICOLOGY REVIEW
FEREAC 71,76180,2006
TOXICOLOGY REVIEW
FEREAC 73,29456,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,551,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
NTP Toxicity studies, RPT# TOX-16, October 2000


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HCKHDV Huanjing Kexue. Environmental Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1976- Adopted vol. no. with Vol. 1, 1980.
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTOX*
ITODC*
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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