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Registry of Toxic Effects of Chemical Substances (RTECS)

Glycine, N-(phosphonomethyl)-

RTECS #

MC1075000

CAS #

1071-83-6

Updated

October 2010

Molecular Weight

169.09

Molecular Formula

C3H8NO5P

Synonyms

Accord
Glifinox
Gliialka
Glyphosate
MON 0573
MON 2139
N-(Phosphonomethyl)glycine
Rodeo
Sonic
Tornado

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/cattle17 µmol/LMUREAV 403,13,1998
DNA Damagefibroblast/human75 mmol/L/1HTOLED5 147,35,2004
DNA Damageovary/hamster5.5 mmol/LEMMUEG 44,179,2004
DNA Damageother cell types/human5.25 mmol/LEMMUEG 44,179,2004
DNA Damageother cell types/human3 mmol/L/4HETOPFR 28,37,2009
micronucleus testintraperitoneal/mouse400 mg/kg/2D- intermittentETOPFR 28,37,2009
other mutation test systemslymphocyte/cattle17 µmol/LMUREAV 403,13,1998
sister chromatid exchangelymphocyte/cattle17 µmol/LMUREAV 403,13,1998
specific locus test/Drosophila melanogaster2 mmol/LEMMUEG 36,40,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 49 gm/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TJADAB 61,446,2000
oral/rat 30 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital systemFEREAC 69,51301,2004
unreported route/mammal (species unspecified) 30 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemFEREAC 63,54060,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >12200 mg/m3/4H85JFAN A222,1984
intraperitoneal/mouse lethal dose (50 percent kill): 130 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TOLED5 1000(Sp Iss 1),148,1980
intraperitoneal/mouse lowest published toxic dose: 400 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
ETOPFR 28,37,2009
intraperitoneal/rat lethal dose (50 percent kill): 235 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TOLED5 1000(Sp Iss 1),148,1980
intravenous/pig lowest published toxic dose: 238.47 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)JTCTDW 47,651,2009
multiple/non-mammalian species lethal dose (50 percent kill): 0.59 gm/m3/24HTOVEFN (6),40,2003
oral/human lowest published toxic dose: 1.67 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
AJEMEN 26,275,2008
oral/human lowest published lethal dose: 1.84 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
AJEMEN 26,275,2008
oral/mammal (species unspecified) lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,51301,2004
oral/man lowest published lethal dose: 2143 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Fibrosing alveolitis
JTCTDW 29,91,1991
oral/man lowest published toxic dose: 1214 mg/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Hypermotility, diarrhea
HETOEA 10,103,1991
oral/man lowest published toxic dose: 1.43 mL/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
AJEMEN 26,384.e3,2008
oral/mouse lethal dose (50 percent kill): 1568 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TXAPA9 45,319,1978
oral/mouse lethal dose (50 percent kill): 2160 mg/kgMUTAEX 21,375,2006
oral/quail lethal dose (50 percent kill): >4640 mg/kgPEMNDP 9,459,1991
oral/rabbit lethal dose (50 percent kill): 3800 mg/kgPESTC* 7,6,1978
oral/rat lethal dose (50 percent kill): >4320 mg/kgJTCTDW 47,651,2009
oral/rat lethal dose (50 percent kill): 4873 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TXAPA9 45,319,1978
oral/woman lowest published lethal dose: 4 gm/kgCardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
JTCTDW 29,91,1991
skin/mammal (species unspecified) lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,51301,2004
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgFEREAC 63,54060,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
multiple/non-mammalian species lowest published toxic dose: 0.53 gm/m3/2D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOVEFN (6),40,2003
multiple/non-mammalian species lowest published toxic dose: 0.033 gm/m3/21D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOVEFN (6),40,2003
multiple/non-mammalian species lowest published toxic dose: 0.26 gm/m3/21D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOVEFN (6),40,2003
oral/mouse lowest published toxic dose: 405000 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,51301,2004
oral/mouse lowest published toxic dose: 435 gm/kg/13W- continuousGastrointestinal: Changes in structure or function of salivary glands

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-92-3135
oral/non-mammalian species lowest published toxic dose: 75 mg/kg/15D- intermittentEndocrine: Androgenic

Endocrine: Estrogenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 23,182,2007
oral/non-mammalian species lowest published toxic dose: 75 mg/kg/15D- intermittentBiochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
REPTED 23,182,2007
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 12,471,2008
oral/rat lowest published toxic dose: 4000 mg/kg/5D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOLED5 180S,S164,2008
oral/rat lowest published toxic dose: 4500 mg/kg/90D- intermittentNutritional and Gross Metabolic: Changes in: P

Nutritional and Gross Metabolic: Changes in: K
FEREAC 69,51301,2004
oral/rat lowest published toxic dose: 49000 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TJADAB 61,446,2000
oral/rat lowest published toxic dose: 153 gm/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3135
oral/rat lowest published toxic dose: 22500 mg/kg/90D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
HCKHDV 5(2),52,1984
oral/rat lowest published toxic dose: 420 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight
REPTED 19,501,2005
oral/rat lowest published toxic dose: 420 mg/kg/21D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 19,501,2005
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentSkin: After systemic exposure: Dermatitis, irritativeFEREAC 67,60934,2002
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, irritative
FEREAC 67,60934,2002
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentSkin: After topical application: Primary irritationFEREAC 69,51301,2004
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Skin: After topical application: Primary irritation
FEREAC 69,51301,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,455,2005
TOXICOLOGY REVIEWJTEHD6 7,267,2004
TOXICOLOGY REVIEWFEREAC 71,32899,2006
TOXICOLOGY REVIEWFEREAC 71,56392,2006
TOXICOLOGY REVIEWFEREAC 71,76180,2006
TOXICOLOGY REVIEWFEREAC 73,29456,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWFEREAC 73,73586,2008
TOXICOLOGY REVIEWFEREAC 73,52607,2008
TOXICOLOGY REVIEWFEREAC 74,29963,2009
TOXICOLOGY REVIEWFEREAC 74,67129,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
NTP Toxicity studies, RPT# TOX-16, October 2000
On EPA IRIS database
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