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Registry of Toxic Effects of Chemical Substances (RTECS)

Glutarimide, 3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-

RTECS #

MA4375000

CAS #

66-81-9

Updated

December 2013

Molecular Weight

281.39

Molecular Formula

C15H23NO4

Synonyms

3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
Acti-Aid
Actidion
Actidione
Actidione BR
Actidione PM
Actidione TGF
Aktidion (Czech)
beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
Cycloheximide
Naramycin
Naramycin A
NSC-185
U-4527

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 5 mg/24H rinseTXCYAC 14,117,1979
skin /rabbit 1 pph/24H moderateNTIS** PB274-414

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/Drosophila melanogaster100 mg/LCLDFAT 2,97,1973
Cytogenetic Analysisother cell types/human100 mg/LEJCAAH 17,173,1981
Cytogenetic Analysislymphocyte/human30 mg/LHEREAY 86,107,1977
Cytogenetic Analysisintravenous/rat20 mg/kgJELJA7 22,205,1973
Cytogenetic Analysisintraperitoneal/mouse100 mg/kgFOBLAN 21,60,1975
Cytogenetic Analysisother cell types/mouse1 µmol/LIPPABX 22,349,1986
DNA adductother cell types/human0.107 mmol/L/6HMOPMA3 57,529,2000
DNA Damagelymphocyte/rat10 mg/L/4HJTSCDR 27,191,2002
DNA Damageother cell types/human0.01 mmol/LMAERE* 53,243,2002
DNA Damagelymphocyte/mouse50 µmol/LMUREAV 203,155,1988
DNA inhibitionother cell types/rat10 mg/LCELLB5 5,311,1975
DNA inhibitionintraperitoneal/rat1500 µg/kgRCOCB8 11,311,1975
DNA inhibitionintraperitoneal/mouse333 mg/kgJCLBA3 30,13,1966
DNA inhibitionfibroblast/mouse180 µmol/LJCLBA3 58,410,1973
DNA inhibitionlung/hamster5 mg/LPNASA6 73,2396,1976
DNA inhibitionfibroblast/hamster1 mg/LJNCIAM 54,431,1975
DNA inhibitionlung/guinea pig10 mg/LPSEBAA 171,109,1982
DNA inhibitionother cell types/human100 mg/LBBACAQ 696,15,1982
DNA inhibitionHeLa cell/human1 µmol/LBCPCA6 14,205,1965
DNA inhibitionlung/human10 mg/LPSEBAA 171,109,1982
DNA inhibitionother cell types/human100 mg/LCNREA8 41,2483,1981
DNA inhibitionother cell types/human300 nmol/LCNREA8 44,2421,1984
DNA inhibition/Other microorganisms90 µmol/LMUREAV 85,275,1981
DNA inhibition/Other microorganisms10 mg/LCELLB5 5,311,1975
DNA inhibition/Other microorganisms100 mg/LCUGED5 5,119,1982
DNA inhibitionkidney/pig1 mg/LCYGEDX 12(1),1,1978
DNA repair/Escherichia coli50 µg/discCNREA8 34,1658,1974
micronucleus testintraperitoneal/mouse10 mg/kgMUREAV 120,127,1983
micronucleus testparenteral/mouse50 mg/kgMUREAV 263,203,1991
morphological transformintraperitoneal/rat1 mg/kgBIZNAT 99,171,1980
mutation in mammalian somatic cellslymphocyte/mouse50600 nmol/LMUTAEX 3,193,1988
mutation in microorganisms/Euglena gracilis500 nmol/L (-enzymatic activation step)CYTZAM 9,280,1974
other mutation test systems/non-mammalian species1 mmol/LABILAE 87,43,1976
other mutation test systemsHeLa cell/human35 µmol/LBCPCA6 14,205,1965
other mutation test systems/Other microorganisms50 mg/LIJBBBQ 19,285,1982
other mutation test systemsintraperitoneal/rat5 mg/kgBCPCA6 18,951,1969
other mutation test systemsintraperitoneal/mouse333 mg/kgJCLBA3 30,13,1966
other mutation test systemsother cell types/guinea pig50 mg/LCBINA8 38,339,1982
other mutation test systems/Other microorganisms10 mg/LCYTZAM 11,392,1975
other mutation test systemsintraperitoneal/rat10 mg/kgBIZNAT 99,171,1980
other mutation test systemskidney/pig1 mg/LCYGEDX 12(1),1,1978
Unscheduled DNA Synthesisfibroblast/mouse10 mg/LCBRPDS 10,455,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1 mg/kg (4D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaINJFA3 27,238,1982
intraperitoneal/rat 300 µg/kg (13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 23,25,1981
intraperitoneal/rat 1 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
BJEPA5 51,361,1970
intraperitoneal/rat 1 mg/kg (18D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
BJEPA5 51,361,1970
intraperitoneal/mouse 30 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 17,41A,1978
intraperitoneal/mouse 30 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 25,345,1982
intraperitoneal/rabbit 5 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Other measures of fertilityFESTAS 38,238,1982
intraperitoneal/rat 250 µg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FAATDF 4,352,1984
intraperitoneal/hamster 60 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Other measures of fertilityPSEBAA 162,170,1979
parenteral/rabbit 5 µg/kg (1D pregnant)Reproductive: Effects on fertility: Other measures of fertilityENDOAO 79,858,1966
parenteral/rat 750 µg/kg (18D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
PCBRD2 140,13,1983
subcutaneous/mouse 80 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathPNASA6 67,779,1970
subcutaneous/mouse 5 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)PNASA6 67,779,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, kidney Inhibitor Concentration (20 percent kill): 0.01 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (20 percent kill): 0.2 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (20 percent kill): 0.09 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (50 percent kill): 0.4 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (50 percent kill): 0.8 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (50 percent kill): 0.4 µmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (50 percent kill): 0.4 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (80 percent kill): 7 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (80 percent kill): 6 µmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 7,149,1993
In Vitro/Hamster, kidney Inhibitor Concentration (80 percent kill): 5 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TIVIEQ 7,149,1993
In Vitro/Hamster, lung Inhibitor Concentration (50 percent kill): 0.023 mg/L/10MIn Vitro Toxicity Studies: Cell countingTIVIEQ 3,317,1989
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 0.013 mg/L/72HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 4,175,1990
In Vitro/Human, colon tumor Inhibitor Concentration Low: 10 mg/L/24HIn Vitro Toxicity Studies: Cell protein synthesis

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXAPA9 245,291,2010
In Vitro/mlbInhibitor Concentration Low: 10 mg/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 247,60,2010
In Vitro/paaInhibitor Concentration Low: 500 µg/L/24HIn Vitro Toxicity Studies: Other assaysNRTXDN 33,476,2012
In Vitro/pzxInhibitor Concentration Low: 100 nmol/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 249,25,2010
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
intraperitoneal/cat lethal dose (50 percent kill): 4 mg/kgJACSAT 70,1223,1948
intraperitoneal/guinea pig lethal dose (50 percent kill): 60 mg/kgANTCAO 10,682,1960
intraperitoneal/hamster lowest published lethal dose: 40 mg/kgPSEBAA 162,170,1979
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgCNCRA6 30,9,1963
intraperitoneal/rat lethal dose (50 percent kill): 3700 µg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
JPETAB 136,400,1962
intraperitoneal/rat lowest published toxic dose: 10 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 216,1,2006
intraperitoneal/rat lowest published toxic dose: 2 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HETOEA 22,245,2003
intravenous/Dog lethal dose (50 percent kill): 1 mg/kgGastrointestinal: Nausea or vomitingARZNAD 8,687,1958
intravenous/mouse lethal dose (50 percent kill): 150 mg/kgJACSAT 69,474,1947
intravenous/rabbit lethal dose (50 percent kill): 17 mg/kgJACSAT 70,1223,1948
intravenous/rat lethal dose (50 percent kill): 2 mg/kgANTCAO 10,682,1960
intravenous/rat lowest published toxic dose: 6 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 241,106,2007
intravenous/rat lowest published toxic dose: 6 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 228,299,2006
intravenous/rat lowest published toxic dose: 5 mg/kgBlood: Changes in bone marrow not included in above

Blood: Changes in spleen
JTSCDR 27,191,2002
intravenous/rat lowest published toxic dose: 6 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 219,175,2006
oral/Dog lethal dose (50 percent kill): 65 mg/kgPCOC** -,292,1966
oral/guinea pig lethal dose (50 percent kill): 65 mg/kgPCOC** -,292,1966
oral/monkey lethal dose (50 percent kill): 60 mg/kgGUCHAZ 6,146,1973
oral/mouse lethal dose (50 percent kill): 133 mg/kgUPJOH* 2(6),-,1971
oral/rat lethal dose (50 percent kill): 2 mg/kgENTOX* -,704,2005
oral/wild bird lethal dose (50 percent kill): 9.38 mg/kgENTOX* -,704,2005
subcutaneous/chicken lowest published lethal dose: 2 mg/kgCBPCBB 66,83,1980
subcutaneous/guinea pig lethal dose (50 percent kill): 60 mg/kgJACSAT 70,1223,1948
subcutaneous/mouse lethal dose (50 percent kill): 160 mg/kgUPJOH* 2(6),-,1971
subcutaneous/rat lethal dose (50 percent kill): 2500 µg/kgANTCAO 10,682,1960
subcutaneous/rat lowest published toxic dose: 1.5 mg/kgBehavioral: Alteration of classical conditioningJOETD7 56,45,1997
unreported route/rat lowest published toxic dose: 2 mg/kgLiver: Other changes

Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 191,26,2003
unreported route/rat lethal dose (50 percent kill): 133 mg/kgYKYUA6 30,397,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 400 mg/kg/4W- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
DCTODJ 6,341,1983
oral/monkey lowest published toxic dose: 56 mg/kg/7D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in erythrocyte (RBC) count
ANTCAO 10,682,1960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 2,159,1973
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWTPHSDY 23,130,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,704,2005
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 750,107,2012
TOXICOLOGY REVIEWEMMUEG 53,683,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,106,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84338; Number of Industries 2; Total Number of Facilities 234; Number of Occupations 7; Total Number of Employees Exposed 3059; Total Number of Female Employees Exposed 2370
National Occupational Hazard Survey 1974Hazard Code 84338; Number of Industries 3; Total Number of Facilities 968; Number of Occupations 6; Total Number of Employees Exposed 4439

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Sperm morphology-mouse
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