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Registry of Toxic Effects of Chemical Substances (RTECS)

D-Glucose

RTECS #

LZ6600000

CAS #

50-99-7

Updated

December 2013

Molecular Weight

180.18

Molecular Formula

C6H12O6

Synonyms

Anhydrous dextrose
Cartose
Cerelose
Corn sugar
Dextropur
Dextrose
Dextrose, anhydrous
Dextrosol
D-Glucose, anhydrous
Glucolin
Glucose
Glucose liquid
Glucose, anhydrous
Grape sugar
Sirup
Sugar, grape

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Other microorganisms150 mmol/LPNASA6 81,105,1984
DNA Damageother cell types/human30 mmol/LJCINAO 77,322,1986
DNA Damageother cell types/human225 mmol/L/5DMUREAV 480-481,371,2001
DNA Damageother cell types/human315 mmol/L/7DMUREAV 480-481,371,2001
DNA Damagelymphocyte/human25 gm/L/1HTOLED5 190,128,2009
mutation in mammalian somatic cellslymphocyte/mouse179 mmol/LMUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium25 mg/plate (+enzymatic activation step)NARHAD 12,2127,1984
other mutation test systems/Other microorganisms1 mole/LARMKA7 91,305,1973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 300 gm/kg (30D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
OYYAA2 6,251,1972
intraperitoneal/hamster 20 gm/kg (6-8D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 33,74C,1986
intraperitoneal/mouse 6000 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)BDERE* 70,438,2004
intravenous/woman 2 gm/kg (39W pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
BJOGAS 89,27,1982
intravenous/woman 1057 µg/kg (39W pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary systemBJOGAS 91,1014,1984
intravenous/woman 1300 mg/kg (39W pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
JPEMAO 16,217,1988
multiple/hamster 20 gm/kg (6-8D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 44,193,1991
multiple/hamster 20 mg/kg (6-8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 44,193,1991
oral/woman 2 gm/kg (28W pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
NEJMAG 315,989,1986
subcutaneous/hamster 20 gm/kg (6-8D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 33,74C,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 15400 gm/kg/22W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
GANNA2 30,419,1936

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endothelium Inhibitor Concentration Low: 25 mmol/L/24HIn Vitro Toxicity Studies: Other assaysPYTOEY 18,1110,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 431 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration Low: 25 mmol/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,1045,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: 20 mmol/LIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,3079,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 30.5 mmol/LBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
FCTOD7 50,3040,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 50 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 136,188,2011
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 100 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
JOETD7 136,188,2011
intraperitoneal/mouse lethal dose (50 percent kill): 18 gm/kgPSEBAA 35,98,1936
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBehavioral: Alteration of classical conditioningPSCHDL 175,457,2004
intraperitoneal/mouse lowest published toxic dose: 365 gm/kgEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EJPHAZ 511,65,2005
intraperitoneal/rat lowest published toxic dose: 2000 mg/kgEndocrine: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
TXAPA9 226,84,2008
intravenous/mouse lethal dose (50 percent kill): 9 gm/kgARZNAD 18,666,1968
intravenous/rabbit lowest published lethal dose: 12 gm/kgHBTXAC 1,150,1955
intravenous/rabbit lowest published toxic dose: 750 mg/kgEye: Increased intraocular pressureIRJPH* 4,95,2005
oral/Dog lowest published lethal dose: 8 gm/kgHBTXAC 1,150,1955
oral/human lowest published toxic dose: 0.357 gm/kgBehavioral: Change in psychophysiological testsJOPSEQ 20,771,2006
oral/man lowest published toxic dose: 357.1 mg/kgBehavioral: Change in psychophysiological testsPSCHDL 202,549,2009
oral/mouse lowest published toxic dose: 2 mg/kgEndocrine: HyperglycemiaJPHSC* 104,29,2007
oral/rabbit lowest published lethal dose: 20 gm/kgHBTXAC 1,150,1955
oral/rat lethal dose (50 percent kill): 25800 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
85AIAL -,39,1973
oral/rat lowest published toxic dose: 2 gm/kgEndocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 182,42,2008
oral/rat lowest published toxic dose: 2 gm/kgEndocrine: HyperglycemiaJPHSC* 104,137,2007
oral/woman lowest published toxic dose: 500 mg/kgBehavioral: Change in psychophysiological testsPSCHDL 202,549,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/domestic animal lowest published toxic dose: 4.4 gm/kg/120H-continuousReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
REPRD* 124,721,2002
oral/rat lowest published toxic dose: 150 mg/kg/15D- continuousBiochemical: Metabolism (intermediary): Lipids including transport

Endocrine: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
BPBLEO 29,889,2006
oral/rat lowest published toxic dose: 700000 mg/kg/35D- continuousGastrointestinal: Other changesFCTOD7 46,752,2008
oral/rat lowest published toxic dose: 840 gm/kg/12W- continuousVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Endocrine: Other changes
BJPCBM 152,280,2007

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 560,101,2004
TOXICOLOGY REVIEWNBREV* 5,279,1981
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWREPTED 35,165,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81836; Number of Industries 86; Total Number of Facilities 11017; Number of Occupations 102; Total Number of Employees Exposed 363666; Total Number of Female Employees Exposed 186490
National Occupational Hazard Survey 1974Hazard Code 81836; Number of Industries 117; Total Number of Facilities 16738; Number of Occupations 90; Total Number of Employees Exposed 136870

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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