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D - Glucose

RTECS #: LZ6600000

CAS #: 50-99-7


UPDATE: February 2009 MW: 180.18 MF: C6H12O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Anhydrous dextrose
  2. Cartose
  3. Cerelose
  4. Corn sugar
  5. D - Glucose, anhydrous
  6. Dextropur
  7. Dextrose
  8. Dextrose, anhydrous
  1. Dextrosol
  2. Glucolin
  3. Glucose
  4. Glucose liquid
  5. Glucose, anhydrous
  6. Grape sugar
  7. Sirup
  8. Sugar, grape


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human other cell types 30 mmol/L JCINAO 77,322,1986
DNA damage human other cell types 225 mmol/L/5 day MUREAV 480-481,371,2001
DNA damage human other cell types 315 mmol/L/7 day MUREAV 480-481,371,2001
DNA damage other microorganisms 150 mmol/L PNASA6 81,105,1984
mutation in microorganisms Salmonella typhimurium 25 mg/plate (+enzymatic activation step) NARHAD 12,2127,1984
mutation in mammalian somatic cells mouse lymphocyte 179 mmol/L MUTAEX 3,193,1988
other mutation test systems other microorganisms 1 mole/L ARMKA7 91,305,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 33,74C,1986
intraperitoneal
mouse
lowest published toxic dose: 6,000 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERE* 70,438,2004
intraperitoneal
rat
lowest published toxic dose: 300 gm/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
OYYAA2 6,251,1972
intravenous
woman
lowest published toxic dose: 2 gm/kg (39 week pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
BJOGAS 89,27,1982
intravenous
woman
lowest published toxic dose: 1,057 g/kg (39 week pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system BJOGAS 91,1014,1984
intravenous
woman
lowest published toxic dose: 1,300 mg/kg (39 week pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
JPEMAO 16,217,1988
multiple
hamster
lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 44,193,1991
multiple
hamster
lowest published toxic dose: 20 mg/kg (6-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 44,193,1991
oral
woman
lowest published toxic dose: 2 gm/kg (28 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
NEJMAG 315,989,1986
subcutaneous
hamster
lowest published toxic dose: 20 gm/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 33,74C,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 15,400 gm/kg/22 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
GANNA2 30,419,1936


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 18 gm/kg N/R PSEBAA 35,98,1936
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Behavioral: Alteration of classical conditioning PSCHDL 175,457,2004
intraperitoneal
mouse
lowest published toxic dose: 365 gm/kg Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EJPHAZ 511,65,2005
intraperitoneal
rat
lowest published toxic dose: 2,000 mg/kg Endocrine: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
TXAPA9 226,84,2008
intravenous
mouse
lethal dose (50 percent kill): 9 gm/kg N/R ARZNAD 18,666,1968
intravenous
rabbit
lowest published lethal dose: 12 gm/kg N/R HBTXAC 1,150,1955
intravenous
rabbit
lowest published toxic dose: 750 mg/kg Eye: Increased intraocular pressure IRJPH* 4,95,2005
oral
dog
lowest published lethal dose: 8 gm/kg N/R HBTXAC 1,150,1955
oral
human
lowest published toxic dose: 0.357 gm/kg Behavioral: Change in psychophysiological tests JOPSEQ 20,771,2006
oral
mouse
lowest published toxic dose: 2 mg/kg Endocrine: Hyperglycemia JPHSC* 104,29,2007
oral
rat
lethal dose (50 percent kill): 25,800 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
85AIAL -,39,1973
oral
rat
lowest published toxic dose: 2 gm/kg Endocrine: Hyperglycemia JPHSC* 104,137,2007
oral
rabbit
lowest published lethal dose: 20 gm/kg N/R HBTXAC 1,150,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
domestic animal
lowest published toxic dose: 4.4 gm/kg/120 hour- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
REPRD* 124,721,2002
oral
rat
lowest published toxic dose: 150 mg/kg/15 day- continuous Biochemical: Metabolism (intermediary): Lipids including transport

Endocrine: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
BPBLEO 29,889,2006
oral
rat
lowest published toxic dose: 700,000 mg/kg/35 day- continuous Gastrointestinal: Other changes FCTOD7 46,752,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 560,101,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81836;
Number of Industries 117;
Total Number of Facilities 16,738;
Number of Occupations 90;
Total Number of Employees Exposed 136,870
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81836;
Number of Industries 86;
Total Number of Facilities 11,017;
Number of Occupations 102;
Total Number of Employees Exposed 363,666;
Total Number of Female Employees Exposed 186,490


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85AIAL "Toxicity of Pure Foods," Boyd, E.M., Cleveland, OH, CRC Press, 1973
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94, 1930-73. For publisher information, see AMICCW.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003-
BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IRJPH*
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987-
JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.1- 1973-
JPHSC*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NARHAD Nucleic Acids Research. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1974-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPRD* Reproduction: the official journal of the Society for the Study of Fertility (Cambridge, England: Society for Reproduction and Fertility) V.121- 2001-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

Click Here for Additional Information about RTECS

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