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Registry of Toxic Effects of Chemical Substances (RTECS)

Glucitol

RTECS #

LZ4290000

CAS #

50-70-4; 36134-87-9; 63800-20-4

Updated

July 2012

Molecular Weight

182.20

Molecular Formula

C6H14O6

Synonyms

Cholaxine
D-Glucitol
Diakarmon
D-Sorbitol
Gulitol
Karion
L-Gulitol
Nivitin
Sionit
Sionon
Sorbicolan
Sorbit
Sorbite
Sorbitol
Sorbo
Sorbol
Sorbostyl
Sorvilande

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster300 mmol/LMUREAV 189,15,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, neurons Inhibitor Concentration Low: 25 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
JOETD7 135,786,2011
intraperitoneal/mouse lethal dose (50 percent kill): 15 gm/kgPSEBAA 35,98,1936
intravenous/mouse lethal dose (50 percent kill): 7100 mg/kgFEREAC 71,4512,2006
intravenous/rat lethal dose (50 percent kill): 7100 mg/kgFAONAU 53A,498,1974
oral/human lowest published toxic dose: 1167 mg/kgGastrointestinal: Other changesFCTOD7 37,233,1999
oral/mouse lethal dose (50 percent kill): 17800 mg/kgYKYUA6 32,1367,1981
oral/rat lethal dose (50 percent kill): 15900 mg/kgFAONAU 53A,498,1974
oral/woman lowest published toxic dose: 1700 mg/kgGastrointestinal: Hypermotility, diarrheaAJDDAL 23,568,1978
subcutaneous/mouse lethal dose (50 percent kill): 24 gm/kgNIIRDN -,607,1990
subcutaneous/rat lethal dose (50 percent kill): 29600 mg/kgNIIRDN -,607,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWNBREV* 17,313,1993

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80530; Number of Industries 126; Total Number of Facilities 18220; Number of Occupations 121; Total Number of Employees Exposed 669284; Total Number of Female Employees Exposed 461984
National Occupational Hazard Survey 1974Hazard Code 80530; Number of Industries 86; Total Number of Facilities 16621; Number of Occupations 80; Total Number of Employees Exposed 144563

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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