Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Gallic acid

RTECS #

LW7525000

CAS #

149-91-7

Updated

December 2013

Molecular Weight

170.13

Molecular Formula

C7H6O5

Synonyms

3,4,5-Trihydroxybenzoic acid
Benzoic acid, 3,4,5-trihydroxy-
Kyselina 3,4,5-trihydroxybenzoova (Czech)
Kyselina gallova (Czech)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse100 µmol/kgIJMRAQ 59,1442,1971
Cytogenetic Analysisovary/hamster50 mg/LCALEDQ 14,251,1981
DNA Damageother cell types/non-mammalian species10 µmol/L/1HMUREAV 539,19,2003
DNA Damageother cell types/hamster15 µmol/L/1HMUREAV 539,127,2003
DNA Damageembryo/salmon10 µmol/L/1HMUREAV 563,89,2004
DNA Damageother cell types/non-mammalian species30 µmol/L/1HMUREAV 603,48,2006
DNA Damagelymphocyte/human100 µmol/L/1HTXAPA9 218,249,2007
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 mg/LMUREAV 135,109,1984
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+/-enzymatic activation step)ABCHA6 45,327,1981
mutation in microorganisms/Escherichia coli750 µg/plate (-enzymatic activation step)MUREAV 467,41,2000
sister chromatid exchangeovary/hamster0.5 mmol/L/3HMUREAV 498,117,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 5 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesENDOAO 57,466,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/hpcInhibitor Concentration Low: 0.25 gm/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 137,914,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 5 mg/L/12HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.FCTOD7 50,3489,2012
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 5 mg/L/4HIn Vitro Toxicity Studies: Other assaysFCTOD7 50,3489,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 50 mg/L/72HIn Vitro Toxicity Studies: Cell protein synthesis

In Vitro Toxicity Studies: Other assays
FCTOD7 49,1820,2011
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 1.6 mg/L/3DIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 82,1279,2011
In Vitro/Human, melanoma Inhibitor Concentration Low: 40 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
FCTOD7 50,1734,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 20 µmol/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
FCTOD7 50,1734,2012
In Vitro/jafInhibitor Concentration (50 percent kill): 44 mg/L/3DIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 82,1279,2011
In Vitro/jdaInhibitor Concentration (50 percent kill): 24 mg/L/3DIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 82,1279,2011
In Vitro/jtfInhibitor Concentration (50 percent kill): 11 mg/L/3DIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 82,1279,2011
In Vitro/Rat, liver tumor Inhibitor Concentration Low: 50 mg/L/72HIn Vitro Toxicity Studies: Cell protein synthesis

In Vitro Toxicity Studies: Other assays
FCTOD7 49,1820,2011
intraperitoneal/mouse lethal dose (50 percent kill): 4300 mg/kgPHTOEH 64,247,1989
intravenous/mouse lethal dose (50 percent kill): 320 mg/kgCSLNX* NX#02597
oral/rabbit lethal dose (50 percent kill): 5 gm/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AJVRAH 23,1264,1962
subcutaneous/rat lowest published lethal dose: 5 gm/kgJAFCAU 17,497,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 28 gm/kg/28D- continuousEndocrine: Changes in spleen weightFCTOD7 39,919,2001
oral/rat lowest published toxic dose: 32.5 gm/kg/13W- continuousBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: P
FCTOD7 39,1063,2001
oral/rat lowest published toxic dose: 91 gm/kg/13W- continuousLiver: Changes in liver weight

Liver: Other changes
FCTOD7 39,1063,2001
oral/rat lowest published toxic dose: 100 gm/kg/13W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P
FCTOD7 39,1063,2001
oral/rat lowest published toxic dose: 291 gm/kg/13W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
FCTOD7 39,1063,2001
oral/rat lowest published toxic dose: 273 gm/kg/13W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 39,1063,2001
oral/rat lowest published toxic dose: 5250 mg/kg/15W- intermittentTumorigenic: Protects against induction of experimental tumorsFCTOD7 49,887,2011
oral/rat lowest published toxic dose: 10850 mg/kg/31W- intermittentGastrointestinal: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 49,887,2011
oral/rat lowest published toxic dose: 560 mg/kg/8W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 134,379,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84280; Number of Industries 14; Total Number of Facilities 294; Number of Occupations 8; Total Number of Employees Exposed 2184; Total Number of Female Employees Exposed 252
National Occupational Hazard Survey 1974Hazard Code 84280; Number of Industries 21; Total Number of Facilities 549; Number of Occupations 10; Total Number of Employees Exposed 2520

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
TOP