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Furan, tetrahydro -

RTECS #: LU5950000

CAS #: 109-99-9


UPDATE: May 2009 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,4 - Epoxybutane
  2. Agrisynth THF
  3. Butane, 1,4 - epoxy -
  4. Butane, alpha,delta - oxide
  5. Cyclotetramethylene oxide
  6. Diethylene oxide
  7. Furanidine
  8. NCI - C60560
  9. Oxacyclopentane
  1. Oxolane
  2. RCRA waste number U213
  3. Tetrahydrofuraan (Dutch)
  4. Tetrahydrofuran
  5. Tetrahydrofuran (ACGIH:OSHA)
  6. Tetrahydrofuranne (French)
  7. Tetraidrofurano (Italian)
  8. Tetramethylene oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 1 Ámol/L (-enzymatic activation step) GTPZAB 26(1),43,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,800 ppm/6 hour (6-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 18,255,1992
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 18,255,1992
oral
mouse
lowest published toxic dose: 2,592 mg/kg (6-17 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** #DE89-001383/LL
oral
mouse
lowest published toxic dose: 2,592 mg/kg (6-17 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #DE89-001383/LL
oral
rat
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #DE89-001383/LL
oral
rat
lowest published toxic dose: 153 gm/kg (91 day male/91 day prior to copulation-7 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FCTOD7 40,1515,2002
oral
rat
lowest published toxic dose: 1.125 mg/kg (multigeneration) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
FCTOD7 40,1515,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,800 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-475,1998
inhalation
mouse
lowest published toxic concentration: 113,400 mg/kg/105 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB98-164544
inhalation
rat
lowest published toxic concentration: 1,800 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-475,1998
inhalation
rat
lowest published toxic concentration: 18,900 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB98-164544


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 25,000 ppm Behavioral: General anesthetic 34ZIAG -,580,1969
inhalation
mouse
lowest published lethal concentration: 24,000 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 5,21,1963
inhalation
mouse
lethal concentration : 19 gm/m3/2 hour Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Blood: Changes in spleen
TPKVAL 5,21,1963
inhalation
rat
lethal concentration (50 percent kill): 21,000 ppm/3 hour Behavioral: Sleep

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
SSEIBV 20,141,1984
inhalation
rat
lethal concentration (50 percent kill): 72 gm/m3/2 hour N/R TPKVAL 10,35,1968
inhalation
rat
lethal concentration : 106 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 10,35,1968
inhalation
rat
lethal concentration : 48 gm/m3 Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TPKVAL 10,35,1968
inhalation
rat
lethal concentration : 41 gm/m3/2 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Necrotic changes
TPKVAL 5,21,1963
inhalation
rat
lowest published toxic concentration: 8 gm/m3/2 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Convulsions or effect on seizure threshold
TPKVAL 5,21,1963
inhalation
rabbit
lethal concentration : >1,200 ppm/4 hour Olfaction: Other olfaction effects SSEIBV 18,89,1982
intraperitoneal
guinea pig
lowest published lethal dose: 500 mg/kg Liver: Fatty liver degeneration AIHAAP 35,21,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 1,900 mg/kg N/R SAIGBL 24,373,1982
intraperitoneal
mouse
lowest published toxic dose: 691.7 mg/kg Behavioral: Ataxia JTCTDW 41,692,2003
intraperitoneal
mouse
lowest published toxic dose: 487.8 mg/kg Behavioral: Muscle weakness JTCTDW 41,692,2003
intraperitoneal
rat
lethal dose (50 percent kill): 2,900 mg/kg N/R SAIGBL 24,373,1982
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects
TPKVAL 5,21,1963
oral
guinea pig
lethal dose (50 percent kill): 2,300 mg/kg N/R GISAAA 34(9),114,1969
oral
rat
lethal dose (50 percent kill): 1,650 mg/kg N/R GAFCC*
oral
rat
lethal dose (50 percent kill): 2.3 mL/kg N/R ENTOX* -,155,2005
oral
rat
lethal dose (20 percent kill): 3,000 mg/kg Lung, Thorax, or Respiration: Respiratory depression TPKVAL 5,21,1963
oral
rat
lethal dose : 4,000 mg/kg N/R TPKVAL 5,21,1963
oral
rat
lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Changes in circulation

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 5,21,1963
skin
mouse
lowest published lethal dose: 100 pph/3 hour Brain and Coverings: Changes in circulation

Blood: Hemorrhage
TPKVAL 5,21,1963
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,21,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5,000 ppm/6 hour/91 day- intermittent Liver: Changes in liver weight

Endocrine: Adrenal cortex hypoplasia

Endocrine: Changes in thymus weight
FAATDF 14,338,1990
inhalation
mouse
lowest published toxic concentration: 200 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-475,1998
inhalation
mouse
lowest published toxic concentration: 15,000 mg/m3/5 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
ARTODN 77,459,2003
inhalation
mouse
lowest published toxic concentration: 8 gm/m3/2 hour/60 day- intermittent Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 5,21,1963
inhalation
mouse
lowest published toxic concentration: 7 gm/m3/20 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 5,21,1963
inhalation
mouse
lowest published toxic concentration: 7 gm/m3/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 5,21,1963
inhalation
mouse
lowest published toxic concentration: 7 gm/m3/61 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 5,21,1963
inhalation
rat
lowest published toxic concentration: 1,000 ppm/4 hour/12 week- intermittent Olfaction: Deviated nasal septum SEEIAY 25,176,1981
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour/91 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count
FAATDF 14,338,1990
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour/18 week- intermittent Liver: Other changes

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
APTOA6 54,221,1984
inhalation
rat
lowest published toxic dose: 5,000 ppm/6 hour/14 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
NTPTR* NTP-TR-475,1998
inhalation
rat
lowest published toxic concentration: 6 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 10,35,1968
inhalation
rat
lowest published toxic concentration: 8 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Cardiac: Changes in coronary arteries

Vascular: Structural changes in vessels
TPKVAL 5,21,1963
inhalation
rat
lowest published toxic concentration: 1.5 gm/m3/61 day- intermittent Blood: Changes in leukocyte (WBC) count TPKVAL 5,21,1963
inhalation
rat
lowest published toxic concentration: 1.5 gm/m3/91 day- intermittent Vascular: BP lowering not characterized in autonomic section TPKVAL 5,21,1963
inhalation
rat
lowest published toxic concentration: 1.5 gm/m3/0.5 year- intermittent Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen
TPKVAL 5,21,1963
oral
mouse
lowest published toxic dose: 4,550 mg/kg/17 week- intermittent Blood: Change in clotting factors

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 32(2),99,1967
oral
mouse
lowest published toxic dose: 3,600 mg/kg/6 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #DE89-001383/LL
oral
mouse
lowest published toxic dose: 2,592 mg/kg/12 day- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #DE89-001383/LL
oral
rat
lowest published toxic dose: 4,550 mg/kg/17 week- intermittent Blood: Change in clotting factors

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 32(2),99,1967
oral
rat
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #DE89-001383/LL
oral
rat
lowest published toxic dose: 4,900 mg/kg/7 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 40,1515,2002
oral
rat
lowest published toxic dose: 26,280 mg/kg/2 year- continuous Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
TOXID9 60,286,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 100 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,155,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (590 mg/m3) DTLVS* 3,252,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (590 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (590 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (590 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (590 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (295 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (150 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 100 ppm (300 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (148 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 150 mg/m3 (50 ppm);
short term exposure limit 300 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (290 mg/m3), short term exposure limit 150 ppm (440 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (150 mg/m3), VLE 100 ppm (300 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 150 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 150 mg/m3, short term exposure limit 300 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (590 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (590 mg/m3), short term exposure limit 250 ppm (735 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (590 mg/m3);
short term exposure limit 250 ppm (735 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (295 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (590 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 600 mg/m3, MAC(short term exposure limit) 750 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (150 mg/m3);
short term exposure limit 80 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (150 mg/m3),KZG- week 100 ppm (300 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (590 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (150 mg/m3);
short term exposure limit 100 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAHYDROFURAN-air 10 hour time-weighted average 200 ppm;
short term exposure limit 250 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71695;
Number of Industries 72;
Total Number of Facilities 4,141;
Number of Occupations 60;
Total Number of Employees Exposed 95,003
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71695;
Number of Industries 101;
Total Number of Facilities 17,866;
Number of Occupations 83;
Total Number of Employees Exposed 356,038;
Total Number of Female Employees Exposed 47,382


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, also used in syntheses
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetrahydrofuran, 1609
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis Studies (inhalation):some evidence:rat NTPTR* NTP-TR-475,1998
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SEEIAY Seikatsu Eisei. Living and Health. (Osaka Seikatsu Eisei Kyokai, c/o Osaka-shiritsu Kankyo Kagaku Kenkyusho, 8-34 Tojo-cho, Tennoji-ku, Osaka, 543, Japan) V.1- 1957-
SSEIBV Sumitomo Sangyo Eisei. Sumitomo Industrial Health. (Sumitomo Byoin Sangyo Eisei Kenkyushitsu, 5-2-2, Nakanoshima, Kita-ku, Osaka 530, Japan) No.1- 1965-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as solvent, also used in syntheses

NIOSH PROFILE (TETRAHYDROFURAN), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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