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2 (3H) - Furanone, dihydro -

RTECS #: LU3500000

CAS #: 96-48-0


UPDATE: May 2009 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Butanolide
  2. 1,4 - Butanolide
  3. 2 - Oxolanone
  4. 4 - Butanolide
  5. 4 - Butyrolactone
  6. 4 - Deoxytetronic acid
  7. 4 - Hydroxybutanoic acid lactone
  8. 4 - Hydroxybutanoic acid, gamma - lactone
  9. 4 - Hydroxybutyric acid lactone
  10. 4 - Hydroxybutyric acid, gamma - lactone
  11. Agrisynth BLO
  12. Butyric acid lactone
  13. Butyric acid, 4 - hydroxy - , gamma - lactone
  14. Butyrolactone
  1. Butyryl lactone
  2. Butyrylactone
  3. C - 1070
  4. Dihydro - 2 (3H) - furanone
  5. NCI - C55878
  6. Tetrahydro - 2 - furanone
  7. gamma - 6480
  8. gamma - BL
  9. gamma - Butyrolactone
  10. gamma - Hydroxybutyric acid cyclic ester
  11. gamma - Hydroxybutyric acid lactone
  12. gamma - Hydroxybutyrolactone
  13. gamma - butyrolactone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 L severe NTIS** OTS0536954


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 2,580 mg/L EMMUEG 13,60,1989
DNA damage Bacillus subtilis 20 L/disc PMRSDJ 1,175,1981
morphological transform hamster kidney 25 mg/L PMRSDJ 1,638,1981
sister chromatid exchange hamster ovary 4,940 mg/L EMMUEG 13,60,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 25 gm/kg (20 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARANDR 10,239,1983
oral
rat
lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) PHTOEH 62,57,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 191 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-406,1992
oral
mouse
lowest published toxic dose: 134,930 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors
NTIS** PB92-189323
skin
mouse
lowest published toxic dose: 50 gm/kg/42 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 31,41,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >5,100 mg/m3/4 hour N/R NTIS** OTS0534527
intramuscular
pigeon
lowest published toxic dose: 18 mg/kg Behavioral: Alteration of operant conditioning JPETAB 317,409,2006
intraperitoneal
mouse
lethal dose (50 percent kill): 1,100 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
AITEAT 13,70,1965
intraperitoneal
mouse
lowest published toxic dose: 54.5 mg/kg Behavioral: Change in motor activity (specific assay) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 66.8 mg/kg Behavioral: Rigidity (includes catalepsy) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 86.8 mg/kg Behavioral: Ataxia JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 279.9 mg/kg Behavioral: Altered sleep time (including change in righting reflex) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 99 mg/kg Behavioral: Muscle weakness JTCTDW 41,692,2003
intraperitoneal
rat
lethal dose (50 percent kill): 1 gm/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
AITEAT 13,70,1965
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Behavioral: Sleep TOSCF2 73,270,2003
intraperitoneal
rat
lowest published toxic dose: 700 mg/kg Behavioral: Somnolence (general depressed activity) JTCTDW 42,735,2004
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg Behavioral: Ataxia JTCTDW 42,741,2004
intravenous
rabbit
lowest published lethal dose: 500 mg/kg N/R AITEAT 13,70,1965
oral
mouse
lethal dose (50 percent kill): 1,460 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 64(2),3,1999
oral
rat
lethal dose (50 percent kill): 1,540 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 31(1),49,1987
parenteral
mouse
lowest published lethal dose: 1,600 mg/kg N/R CBCCT* 7,687,1955
skin
guinea pig
lethal dose (50 percent kill): >5 gm/kg N/R GAFCC*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5,030 g/m3/24 hour/17 week- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 64(2),3,1999
oral
mouse
lowest published toxic dose: 68 gm/kg/16 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-406,1992
oral
mouse
lowest published toxic dose: 134,930 mg/kg/103 week- intermittent Liver: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB92-189323
oral
rat
lowest published toxic dose: 9,600 mg/kg/30 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
GISAAA 64(2),3,1999
oral
rat
lowest published toxic dose: 9,600 mg/kg/16 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-406,1992
oral
rat
lowest published toxic dose: 40,950 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-406,1992
oral
rat
lowest published toxic dose: 115,875 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB92-189323


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 11,231,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal No Evidence IMEMDT 71,367,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 11,231,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,367,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,367,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
JJATDK 26,72,2006
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (tentative), OCT 2002
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1130;
Number of Industries 12;
Total Number of Facilities 1,476;
Number of Occupations 18;
Total Number of Employees Exposed 5,155
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1130;
Number of Industries 38;
Total Number of Facilities 4,447;
Number of Occupations 42;
Total Number of Employees Exposed 44,126;
Total Number of Female Employees Exposed 11,013


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate in the production of 2-PYRROLIDONE, and as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE

AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962-
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as a chemical intermediate in the production of 2-PYRROLIDONE, and as a solvent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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