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2 - Furanmethanol, tetrahydro -

RTECS #: LU2450000

CAS #: 97-99-4


UPDATE: November 2008 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Furfuryl alcohol, tetrahydro -
  2. QO Thfa
  3. THFA
  4. Tetrahydro - 2 - furancarbinol
  5. Tetrahydro - 2 - furanmethanol
  1. Tetrahydrofurfuryl alcohol
  2. Tetrahydrofurfurylalkohol (Czech)
  3. Tetrahydrofurylalkohol (Czech)
  4. Tetrahydro - 2 - furylmethanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,786,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** OTS0557931
skin
rat
lowest published toxic dose: 65 gm/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** OTS0557932


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lethal dose (50 percent kill): 400 mg/kg N/R 38MKAJ 2C,4658,1982
intraperitoneal
rat
lethal dose (50 percent kill): 400 mg/kg N/R 38MKAJ 2C,4658,1982
intravenous
rabbit
lethal dose (50 percent kill): 725 mg/kg N/R FEPRA7 8,294,1949
oral
guinea pig
lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4658,1982
oral
mouse
lethal dose (50 percent kill): 2,300 mg/kg Behavioral: General anesthetic HYSAAV 32(2),273,1967
oral
rat
lethal dose (50 percent kill): 1,600 mg/kg N/R 38MKAJ 2C,4658,1982
skin
guinea pig
lethal dose (50 percent kill): 5 gm/kg N/R 38MKAJ 2C,4658,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/13 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Blood: Changes in platelet count

Related to Chronic Data: Changes in prostate weight
NTIS** OTS0557931
oral
rat
lowest published toxic dose: 54 gm/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0535211
oral
rat
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535211-2
skin
rat
lowest published toxic dose: 65 gm/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0556424


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FEREAC 71,18689,2006
TOXICOLOGY REVIEW
FEREAC 71,45411,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83085;
Number of Industries 9;
Total Number of Facilities 1,654;
Number of Occupations 9;
Total Number of Employees Exposed 2,169
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83085;
Number of Industries 41;
Total Number of Facilities 5,004;
Number of Occupations 33;
Total Number of Employees Exposed 81,543;
Total Number of Female Employees Exposed 48,075


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as biocide carrier in industrial cleaners, coating removers, chemical intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as biocide carrier in industrial cleaners, coating removers, chemical intermediate

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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