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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Furanmethanol, tetrahydro-

RTECS #

LU2450000

CAS #

97-99-4

Updated

July 2011

Molecular Weight

102.15

Molecular Formula

C5H10O2

Synonyms

Furfuryl alcohol, tetrahydro-
QO Thfa
Tetrahydro-2-furancarbinol
Tetrahydro-2-furanmethanol
Tetrahydro-2-furylmethanol
Tetrahydrofurfuryl alcohol
Tetrahydrofurfurylalkohol (Czech)
Tetrahydrofurylalkohol (Czech)
THFA

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,786,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 500 ppm/6H (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** OTS0557931
oral/rat 25 gm/kg (2W male/2W prior to copulation/1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)REPTED 25,231,2008
oral/rat 7000 mg/kg (1-14D prior to copulation)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)REPTED 25,231,2008
oral/rat 7.4 gm/kg (2W male/2W prior to copulation/1-21D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 25,231,2008
oral/rat 7990 mg/kg (14D male/14D pre-4D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)REPTED 25,231,2008
skin/rat 65 gm/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** OTS0557932

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 178 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/guinea pig lethal dose (50 percent kill): 400 mg/kg38MKAJ 2C,4658,1982
intraperitoneal/rat lethal dose (50 percent kill): 400 mg/kg38MKAJ 2C,4658,1982
intravenous/rabbit lethal dose (50 percent kill): 725 mg/kgFEPRA7 8,294,1949
oral/guinea pig lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4658,1982
oral/mouse lethal dose (50 percent kill): 2300 mg/kgBehavioral: General anestheticHYSAAV 32(2),273,1967
oral/rat lethal dose (50 percent kill): 1600 mg/kg38MKAJ 2C,4658,1982
skin/guinea pig lethal dose (50 percent kill): 5 gm/kg38MKAJ 2C,4658,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/6H/13W- intermittentBehavioral: Convulsions or effect on seizure threshold

Blood: Changes in platelet count

Related to Chronic Data: Changes in prostate weight
NTIS** OTS0557931
oral/rat lowest published toxic dose: 54 gm/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0535211
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535211-2
oral/rat lowest published toxic dose: 5100 mg/kg/34D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 25,231,2008
oral/rat lowest published toxic dose: 7050 mg/kg/47D- intermittentBlood: Changes in spleenREPTED 25,231,2008
oral/rat lowest published toxic dose: 7050 mg/kg/47D- intermittentEndocrine: Changes in pituitary weightREPTED 25,231,2008
oral/rat lowest published toxic dose: 23500 mg/kg/47D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in spleen
REPTED 25,231,2008
oral/rat lowest published toxic dose: 7050 mg/kg/47D- intermittentEndocrine: Changes in pituitary weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 25,231,2008
oral/rat lowest published toxic dose: 23500 mg/kg/47D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
REPTED 25,231,2008
oral/rat lowest published toxic dose: 23500 mg/kg/47D- intermittentBlood: Changes in spleen

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 25,231,2008
skin/rat lowest published toxic dose: 65 gm/kg/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0556424

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEREAC 71,18689,2006
TOXICOLOGY REVIEWFEREAC 71,45411,2006
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83085; Number of Industries 41; Total Number of Facilities 5004; Number of Occupations 33; Total Number of Employees Exposed 81543; Total Number of Female Employees Exposed 48075
National Occupational Hazard Survey 1974Hazard Code 83085; Number of Industries 9; Total Number of Facilities 1654; Number of Occupations 9; Total Number of Employees Exposed 2169

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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