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Furan

RTECS #: LT8524000

CAS #: 110-00-9


UPDATE: February 2009 MW: 68.08 MF: C4H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,4 - Epoxy - 1,3 - butadiene
  2. Axole
  3. Divinylene oxide
  4. Furfuran
  5. NCI - C56202
  1. Oxacyclopentadiene
  2. Oxole
  3. RCRA waste number U124
  4. Tetrole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 184 mmol/L CALEDQ 13,89,1981
DNA damage intraperitoneal
rat
5 mg/kg TOXID9 60,154,2001
DNA repair Bacillus subtilis 3,500 µg/disc DFSCDX 13,353,1986
unscheduled DNA synthesis rat liver 30 µmol/L/3 hour TOXID9 66,182,2002
mutation in microorganisms Salmonella typhimurium 825 nmol/plate (+/-enzymatic activation step) DFSCDX 13,353,1986
micronucleus test rat liver 10 µmol/L/3 hour TOXID9 66,182,2002
mutation in mammalian somatic cells mouse lymphocyte 1,139 mg/L EMMUEG 12,85,1988
sister chromatid exchange hamster lung 3 µmol/L/32 hour MUREAV 580,41,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3,900 mg/kg (13 week male/13 week prior to copulation) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Ovaries, fallopian tubes
NTPTR* NTP-TR-402,1993
oral
rat
lowest published toxic dose: 520 mg/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 -,176,2008


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,160 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-402,1993
oral
mouse
lowest published toxic dose: 4,120 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB93-228419
oral
rat
lowest published toxic dose: 1,040 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma
NTPTR* NTP-TR-402,1993
oral
rat
lowest published toxic dose: 1,950 mg/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma
NTIS** PB93-228419
oral
rat
lowest published toxic dose: 1,030 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma
NTIS** PB93-228419
oral
rat
lowest published toxic dose: 1,030 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB93-228419
oral
rat
lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB93-228419
oral
rat
lowest published toxic dose: 1,080 mg/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Angiosarcoma

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 192,71,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 120 mg/m3/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AIHAAP 40,310,1979
inhalation
mouse
lethal concentration (50 percent kill): 120 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema ENTOX* -,392,2005
inhalation
mouse
lethal concentration (50 percent kill): 3 gm/m3 N/R TPKVAL 9,3,1967
inhalation
mouse
lethal concentration (50 percent kill): 3 gm/m3/2 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 9,106,1967
inhalation
mouse
lowest published lethal concentration: 2 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: General anesthetic

Behavioral: Muscle weakness
TPKVAL 9,106,1967
inhalation
rat
lethal concentration (50 percent kill): 3,398 ppm/1 hour Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HAZL** HLA468-102,1987
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/4 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TPKVAL 12,44,1971
inhalation
rat
lowest published lethal concentration: 1.5 gm/m3/4 hour Blood: Methemoglobinemia- Carboxhemoglobinemia

Immunological Including Allergic: Decrease in cellular immune response
TPKVAL 12,44,1971
inhalation
rat
lowest published toxic concentration: 0.7 gm/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TPKVAL 12,44,1971
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/4 hour N/R TPKVAL 12,44,1971
inhalation
rat
lethal concentration (50 percent kill): 2.8 gm/m3/2 hour N/R TPKVAL 10,35,1968
inhalation
rat
lethal concentration : 4.2 gm/m3 N/R TPKVAL 10,35,1968
inhalation
rat
lethal concentration : 1.8 gm/m3 Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TPKVAL 10,35,1968
inhalation
rat
lethal concentration (50 percent kill): 3 gm/m3 N/R TPKVAL 9,3,1967
inhalation
rat
lowest published toxic concentration: 3 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
TPKVAL 9,106,1967
inhalation
rat
lowest published toxic concentration: 1.75 gm/m3/2 hour Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Hemorrhage
TPKVAL 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/4 hour Liver: Other changes

Biochemical: Metabolism (intermediary): Glycolytic
TPKVAL 9,106,1967
intraperitoneal
mouse
lethal dose (50 percent kill): 7 mg/kg N/R AIHAAP 40,310,1979
intraperitoneal
mouse
lowest published lethal dose: 300 mg/kg Behavioral: Somnolence (general depressed activity) TOLED5 169,43,2007
intraperitoneal
mouse
lowest published toxic dose: 225 mg/kg Behavioral: Somnolence (general depressed activity) TOLED5 169,43,2007
intraperitoneal
rat
lethal dose (50 percent kill): 5,200 µg/kg N/R AIHAAP 40,310,1979
intravenous
dog
lowest published lethal dose: 140 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Hemorrhage
JPETAB 26,281,1926
oral
dog
lowest published lethal dose: 234 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage
JPETAB 26,281,1926
oral
rat
lowest published toxic dose: 40 mg/kg/24 hour Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes
MUREAV 549,147,2004
oral
rat
lowest published toxic dose: 40 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Changes in liver weight
MUREAV 549,169,2004
oral
rat
lowest published toxic dose: 4 mg/kg Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) MUREAV 549,169,2004
oral
rabbit
lowest published lethal dose: 234 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage
JPETAB 26,281,1926
subcutaneous
mouse
lowest published lethal dose: 275 mg/kg Behavioral: Somnolence (general depressed activity) TOLED5 169,43,2007
skin
mouse
lethal dose : 100 pph/30 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
TPKVAL 9,106,1967
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 9,106,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.5 gm/m3/0.5 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TPKVAL 12,44,1971
inhalation
rat
lowest published toxic concentration: 0.65 gm/m3/2 week- intermittent Brain and Coverings: Changes in circulation

Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.65 gm/m3/2 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Other changes
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.65 gm/m3/2 week- intermittent Liver: Changes in liver weight

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/61 day- intermittent Brain and Coverings: Changes in circulation

Cardiac: Changes in coronary arteries

Vascular: Other changes
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/61 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Multiple effects
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/61 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.65 gm/m3/61 day- intermittent Blood: Changes in leukocyte (WBC) count TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/91 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/153 day- intermittent Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/122 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Changes in other cell count (unspecified)
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/183 day- intermittent Cardiac: Other changes

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/183 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOVEFN 9,106,1967
inhalation
rat
lowest published toxic concentration: 200 mg/m3/4 hour/60 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 9,106,1967
inhalation
rat
lowest published toxic concentration: 500 mg/m3/2 hour/9 week- intermittent Liver: Jaundice, other or unclassified

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 10,35,1968
inhalation
rat
lowest published toxic concentration: 5 mg/m3/4 hour/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Vascular: BP lowering not characterized in autonomic section
TPKVAL 10,35,1968
inhalation
rat
lowest published toxic concentration: 500 mg/m3/2 hour/30 day- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 9,106,1967
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/0.5 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TPKVAL 12,44,1971
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 10,35,1968
oral
mouse
lowest published toxic dose: 1,950 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-402,1993
oral
mouse
lowest published toxic dose: 2,730 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-402,1993
oral
mouse
lowest published toxic dose: 80 mg/kg/26 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,353,2004
oral
mouse
lowest published toxic dose: 4,160 mg/kg/2 year- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 60,154,2001
oral
mouse
lowest published toxic dose: 2,080 mg/kg/2 year- intermittent Liver: Tumors

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,154,2001
oral
rat
lowest published toxic dose: 600 mg/kg/2 week- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJPAA4 145,375,1994
oral
rat
lowest published toxic dose: 240 mg/kg/16 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-402,1993
oral
rat
lowest published toxic dose: 3,900 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-402,1993
oral
rat
lowest published toxic dose: 120 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MUREAV 549,169,2004
oral
rat
lowest published toxic dose: 560 mg/kg/14 day- intermittent Liver: Other changes MUREAV 549,169,2004
oral
rat
lowest published toxic dose: 520 mg/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight
TOXID9 -,176,2008
oral
rat
lowest published toxic dose: 520 mg/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
TOXID9 -,176,2008
oral
rat
lowest published toxic dose: 130 mg/kg/90 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,176,2008
oral
rat
lowest published toxic dose: 520 mg/kg/90 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 -,176,2008
skin
rabbit
lowest published toxic dose: 100 pph/7 day- intermittent Skin: After topical application: Primary irritation TOVEFN 9,106,1967
unreported route
rat
lowest published toxic dose: 2,940 mg/kg/12 week- intermittent Liver: Other changes TOXID9 66,63,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,393,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,393,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 63,393,1995
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,392,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 34185;
Number of Industries 2;
Total Number of Facilities 25;
Number of Occupations 3;
Total Number of Employees Exposed 244
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 34185;
Number of Industries 2;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 35;
Total Number of Female Employees Exposed 7


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of herbicides and pharmaceuticals
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HAZL** Hazelton Laboratories, Reports. (Falls Church, VA)
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as intermediate in production of herbicides and pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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