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Registry of Toxic Effects of Chemical Substances (RTECS)

Fumaric acid

RTECS #

LS9625000

CAS #

110-17-8

Updated

August 2009

Molecular Weight

116.08

Molecular Formula

C4H4O4

Synonyms

1,2-Ethenedicarboxylic acid, trans-
1,2-Ethylenedicarboxylic acid, (E)
Allomaleic acid
Boletic acid
Butenedioic acid, (E)-
Kyselina fumarova (Czech)
Lichenic acid
NSC-2752
trans-1,2-Ethylenedicarboxylic acid
trans-Butenedioic acid
U-1149
USAF EK-P-583

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,313,1986
skin /rabbit 500 mg/24H mild85JCAE -,313,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionintravenous/rat40 mg/kgJJCREP 77,750,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 110 mg/m3/4HLiver: Changes in liver weightTOVEFN (2),27,1994
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
intraperitoneal/rat lowest published lethal dose: 587 mg/kgGastrointestinal: Other changes

Liver: Other changes

Blood: Hemorrhage
JAPMA8 35,298,1946
intraperitoneal/rat lowest published toxic dose: 10 mg/kgBehavioral: Tremor

Liver: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
HPV093 -,-,2001
intraperitoneal/rat lowest published toxic dose: 100 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Urine volume increased
HPV093 -,-,2001
oral/mouse lethal dose (50 percent kill): 5000 mg/kgOlfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation
TOVEFN (2),27,1994
oral/rabbit lowest published lethal dose: 5 gm/kgIECHAD 15,628,1923
oral/rat lethal dose (50 percent kill): 6800 mg/kgOlfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation
TOVEFN (2),27,1994
oral/rat lethal dose (50 percent kill): 9300 mg/kgHPV093 -,-,2001
skin/rabbit lethal dose (50 percent kill): >20000 mg/kgHPV093 -,-,2001
unreported route/mouse lethal dose (50 percent kill): 5 gm/kgOlfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation
TOVEFN (2),25,1994
unreported route/rat lethal dose (50 percent kill): 6800 mg/kgOlfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation
TOVEFN (2),25,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 28000 mg/kg/40W- continuousGastrointestinal: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
VOONC* -,956,1992
oral/rat lowest published toxic dose: 36400 mg/kg/52W- continuousKidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
VOONC* -,956,1992
oral/rat lowest published toxic dose: 182500 mg/kg/2Y- intermittentGastrointestinal: GastritisHPV093 -,-,2001
oral/rat lowest published toxic dose: 547500 mg/kg/2Y- intermittentGastrointestinal: Gastritis

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV093 -,-,2001
skin/mouse lowest published toxic dose: 600 mg/kg/3D- intermittentBlood: Other changesFCTOD7 46,1896,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTPHSDY 24,613,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 33940; Number of Industries 40; Total Number of Facilities 5692; Number of Occupations 58; Total Number of Employees Exposed 136448; Total Number of Female Employees Exposed 48919
National Occupational Hazard Survey 1974Hazard Code 33940; Number of Industries 27; Total Number of Facilities 2317; Number of Occupations 44; Total Number of Employees Exposed 30637

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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