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D - Fructose

RTECS #: LS7120000

CAS #: 57-48-7


UPDATE: May 2009 MW: 180.18 MF: C6H12O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Fructose, D - (8CI)
  2. Fructose
  3. Fruit sugar
  4. Furucton
  1. Levulose
  2. Nevulose
  3. arabino - Hexulose


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lethal dose (50 percent kill): 15 gm/kg N/R NTIS** AD-A132-656
oral
rat
lowest published toxic dose: 4 gm/kg N/R JOETD7 79,17,2002
oral
rat
lowest published toxic dose: 4 gm/kg Kidney, Ureter, and Bladder: Other changes in urine composition JOETD7 79,17,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 119 mg/kg/14 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A132-656
oral
rat
lowest published toxic dose: 140 gm/kg/2 week- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
JPETAB 302,232,2002
oral
rat
lowest published toxic dose: 70 gm/kg/1 week- continuous Behavioral: Fluid intake JOETD7 83,183,2002
oral
rat
lowest published toxic dose: 70 gm/kg/3 week- continuous Behavioral: Food intake (animal)

Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section
JOETD7 83,183,2002
oral
rat
lowest published toxic dose: 42 gm/kg/1 week- continuous Vascular: BP elevation not characterized in autonomic section BPBLEO 27,1779,2004
oral
rat
lowest published toxic dose: 168 gm/kg/4 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Endocrine: Other changes
BPBLEO 27,1779,2004
oral
rat
lowest published toxic dose: 700,000 mg/kg/35 day- continuous Gastrointestinal: Other changes

Liver: Changes in liver weight
FCTOD7 46,752,2008
oral
rat
lowest published toxic dose: 2,160 gm/kg/60 day- intermittent Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
SIMEJ* 47,858,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HTOPA*
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SIMEJ*

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