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Registry of Toxic Effects of Chemical Substances (RTECS)

D-Fructose

RTECS #

LS7120000

CAS #

57-48-7

Updated

April 2013

Molecular Weight

180.18

Molecular Formula

C6H12O6

Synonyms

arabino-Hexulose
Fructose
Fructose, D- (8CI)
Fruit sugar
Furucton
Levulose
Nevulose

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/rabbit lethal dose (50 percent kill): 15 gm/kgNTIS** AD-A132-656
oral/rat lowest published toxic dose: 4 gm/kgJOETD7 79,17,2002
oral/rat lowest published toxic dose: 4 gm/kgKidney, Ureter, and Bladder: Other changes in urine compositionJOETD7 79,17,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 119 mg/kg/14D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A132-656
oral/rat lowest published toxic dose: 140 gm/kg/2W- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
JPETAB 302,232,2002
oral/rat lowest published toxic dose: 70 gm/kg/1W- continuousBehavioral: Fluid intakeJOETD7 83,183,2002
oral/rat lowest published toxic dose: 70 gm/kg/3W- continuousBehavioral: Food intake (animal)

Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section
JOETD7 83,183,2002
oral/rat lowest published toxic dose: 42 gm/kg/1W- continuousVascular: BP elevation not characterized in autonomic sectionBPBLEO 27,1779,2004
oral/rat lowest published toxic dose: 168 gm/kg/4W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Endocrine: Other changes
BPBLEO 27,1779,2004
oral/rat lowest published toxic dose: 700000 mg/kg/35D- continuousGastrointestinal: Other changes

Liver: Changes in liver weight
FCTOD7 46,752,2008
oral/rat lowest published toxic dose: 2160 gm/kg/60D- intermittentEndocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
SIMEJ* 47,858,2006
oral/rat lowest published toxic dose: 605.25 gm/kg/8W- continuousVascular: BP elevation not characterized in autonomic section

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
BPBLEO 31,2103,2008
oral/rat lowest published toxic dose: 140 gm/kg/2W- continuousCardiac: Cardiac output

Cardiac: Other changes
BJPCBM 151,341,2007
oral/rat lowest published toxic dose: 700 gm/kg/8W- continuousVascular: BP elevation not characterized in autonomic section

Vascular: Contraction (isolated tissue)

Vascular: Relaxation (isolated tissue)
BCLPT* 102(Suppl 1),54,2008
oral/rat lowest published toxic dose: 140 gm/kg/2W- continuousVascular: BP elevation not characterized in autonomic section

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JPETAB 328,610,2009
oral/rat lowest published toxic dose: 2376 gm/kg/60D- intermittentEndocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 47,2224,2009
oral/rat lowest published toxic dose: 560 gm/kg/8W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Xanthine oxidases

Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate
JOETD7 135,399,2011
oral/rat lowest published toxic dose: 840 gm/kg/12W- continuousVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Endocrine: Other changes
FCTOD7 49,3007,2011

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWNBREV* 5,1,1981

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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