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Formamide, 1,1' - azobis -

RTECS #: LQ1040000

CAS #: 123-77-3


UPDATE: August 2007 MW: 116.10 MF: C2H4N4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1' - Azobis (formamide)
  2. 1,1' - Azobiscarbamide
  3. Azobiscarbonamide
  4. Azobiscarboxamide
  5. Azodicarbamide
  6. Azodicarboamide
  7. Azodicarbonamide
  8. Azodicarboxamide
  9. Azodicarboxylic acid diamide
  10. Celosen AZ
  11. ChKhz 21
  12. ChKhz 21R
  13. Diazenedicarboxamide
  14. Genitron AC 2
  15. Genitron AC 4
  16. Genitron AC
  1. Kempore
  2. Kempore 125
  3. Kempore R 125
  4. Lucel ADA
  5. NCI - C55981
  6. Nitropore
  7. Pinhole AK 2
  8. Porofor 505
  9. Porofor adc/R
  10. Porofor Chkhz 21
  11. Porofor Chkhz 21R
  12. Unifoam AZ
  13. Uniform AZ
  14. Yunihomu AZ
  15. delta (1,1') - Biurea


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 g/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 440 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
ATDAEI 15(Suppl 1),S66,1996
oral
rat
lethal dose (50 percent kill): >6,400 mg/kg N/R AIHAAP 48,127,1987
skin
rat
lethal dose (50 percent kill): >500 mg/kg N/R ATDAEI 15(Suppl 1),S66,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 217 mg/m3/6 hour/2 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation
mouse
lowest published toxic concentration: 204 mg/m3/6 hour/13 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation
rat
lowest published toxic concentration: 207 mg/m3/6 hour/2 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation
rat
lowest published toxic concentration: 204 mg/m3/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) FAATDF 15,308,1990
intraperitoneal
rat
lowest published toxic dose: 252 mg/kg/1 week- intermittent Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JCEMAZ 32,659,1971
oral
rat
lowest published toxic dose: 42 gm/kg/10 day- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
JCEMAZ 32,659,1971
oral
rat
lowest published toxic dose: 233 gm/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction JCEMAZ 32,659,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - THE NETHERLANDS MAC-TGG intermittent mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND sen, JAN2002
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3 (sen), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81713;
Number of Industries 32;
Total Number of Facilities 1,753;
Number of Occupations 60;
Total Number of Employees Exposed 43,147
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81713;
Number of Industries 18;
Total Number of Facilities 1,210;
Number of Occupations 29;
Total Number of Employees Exposed 42,296;
Total Number of Female Employees Exposed 17,091


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dynamic foaming processes, and as a blowing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-

Used in dynamic foaming processes, and as a blowing agent

RTECS Compound Description:
   Mutagen

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