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Registry of Toxic Effects of Chemical Substances (RTECS)

Formamide, 1,1'-azobis-

RTECS #

LQ1040000

CAS #

123-77-3

Updated

April 2012

Molecular Weight

116.10

Molecular Formula

C2H4N4O2

Synonyms

1,1'-Azobis(formamide)
1,1'-Azobiscarbamide
Azobiscarbonamide
Azobiscarboxamide
Azodicarbamide
Azodicarboamide
Azodicarbonamide
Azodicarboxamide
Azodicarboxylic acid diamide
Celosen AZ
ChKhz 21
ChKhz 21R
delta(1,1')-Biurea
Diazenedicarboxamide
Genitron AC
Genitron AC 2
Genitron AC 4
Kempore
Kempore 125
Kempore R 125
Lucel ADA
NCI-C55981
Nitropore
Pinhole AK 2
Porofor 505
Porofor adc/R
Porofor Chkhz 21
Porofor Chkhz 21R
Unifoam AZ
Uniform AZ
Yunihomu AZ

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/cattle500 µmol/L/1HMUREAV 536,91,2003
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)ENMUDM 8(Suppl 7),1,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 440 mg/kgLung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
ATDAEI 15(Suppl 1),S66,1996
oral/rat lethal dose (50 percent kill): >6400 mg/kgAIHAAP 48,127,1987
skin/rat lethal dose (50 percent kill): >500 mg/kgATDAEI 15(Suppl 1),S66,1996

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 217 mg/m3/6H/2W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation/mouse lowest published toxic concentration: 204 mg/m3/6H/13W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation/rat lowest published toxic concentration: 207 mg/m3/6H/2W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,308,1990
inhalation/rat lowest published toxic concentration: 204 mg/m3/6H/13W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)FAATDF 15,308,1990
intraperitoneal/rat lowest published toxic dose: 252 mg/kg/1W- intermittentKidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JCEMAZ 32,659,1971
oral/rat lowest published toxic dose: 42 gm/kg/10D- continuousEndocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
JCEMAZ 32,659,1971
oral/rat lowest published toxic dose: 233 gm/kg/4W- continuousEndocrine: Evidence of thyroid hypofunctionJCEMAZ 32,659,1971

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDsen, JAN2002
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG I mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81713; Number of Industries 18; Total Number of Facilities 1210; Number of Occupations 29; Total Number of Employees Exposed 42296; Total Number of Female Employees Exposed 17091
National Occupational Hazard Survey 1974Hazard Code 81713; Number of Industries 32; Total Number of Facilities 1753; Number of Occupations 60; Total Number of Employees Exposed 43147

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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