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Registry of Toxic Effects of Chemical Substances (RTECS)

Formamidine, N'-(4-chloro-o-tolyl)-N,N-dimethyl-, hydrochloride

RTECS #

LQ4550000

CAS #

19750-95-9; 23167-93-3

Updated

August 2007

Molecular Weight

233.16

Molecular Formula

C10H13ClN2·ClH

Synonyms

CGA-72651
Chlordimeform hydrochloride
Chlorophenamidine hydrochloride
ENT 27567
EP 333
Fundal SP
Galecron monohydrochloride
Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl-, monohydrochloride (9CI)
Morton EP 333
N'-(4-Chloro-o-tolyl)-N,N-dimethylformamidine, hydrochloride
N,N-Dimethyl-N'-(2-methyl-4-chlorophenyl)-formamidine, hydrochloride
Nor-AM EP 333
NSC 195102
Spanone
Spanone monohydrochloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildCIGET*

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 85500 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
PCBPBS 9,148,1978
oral/mouse lethal dose (50 percent kill): 290 mg/kgBESAAT 15,103,1969
oral/rabbit lethal dose (50 percent kill): 625 mg/kgBESAAT 15,103,1969
oral/rat lethal dose (50 percent kill): 225 mg/kgSPEADM 78-1,22,1978
skin/rabbit lethal dose (50 percent kill): >4 gm/kgSPEADM 78-1,22,1978
skin/rat lethal dose (50 percent kill): 4 gm/kgSPEADM 78-1,22,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 3600 mg/kg/60D- continuousLiver: Change in gall bladder structure or function

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
NTIS** OTS0543161
oral/rat lowest published toxic dose: 21600 mg/kg/60D- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0543167

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,544,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,96,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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