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Registry of Toxic Effects of Chemical Substances (RTECS)

Formamidine, N'-(4-chloro-o-tolyl)-N,N-dimethyl-

RTECS #

LQ4375000

CAS #

6164-98-3

Updated

April 2012

Molecular Weight

196.70

Molecular Formula

C10H13ClN2

Synonyms

Acaron
Bermat
C 8514
CDM
Chlordimeform
Chlorfenamidine
Chlorophenamidin
Chlorophenamidine
Chlorphenamidine
CIBA-8514
ENT-27335
Fundal
Fundal 500
Galecron
Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl-
N'-(2-Methyl-4-chlorophenyl)-N,N-dimethylformamidine
N'-(4-Chloro-2-methylphenyl)-N,N-dimethylmethanimidamide
N'-(4-Chloro-o-tolyl)-N,N-dimethylformamidine
N'-(4-Chlor-o-tolyl)-N,N-dimethylformamidin (German)
N(sup 2)-(4-Chloro-o-tolyl)-N(sup 1),N(sup 1)-dimethylformamidine
N,N-Dimethyl-N'-(2-methyl-4-chlorophenyl)formamidine
N,N-Dimethyl-N'-(2-methyl-4-chlorphenyl)-formadin (German)
NSC 190935
Ovatoxion
RS 141
Schering 36268
SN 36268

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeCIGET*

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionHeLa cell/human1 mmol/LBECTA6 11,184,1974
mutation in microorganisms/Salmonella typhimurium2 µmol/plate (-enzymatic activation step)JAFCAU 34,157,1986
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
other mutation test systemsHeLa cell/human1 mmol/LBECTA6 11,184,1974
specific locus testmultiple/Drosophila melanogaster10 ppbEMMUEG 25,148,1995

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1800 µg/kg (5-22D pregnant)Reproductive: Effects on newborn: BehavioralBECTA6 20,760,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 6552 mg/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Lung, Thorax, or Respiration: Tumors
CHYCDW 19,154,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): >5800 mg/m3/1H85JFAN A074,1983
intraperitoneal/hamster lethal dose (50 percent kill): 200 mg/kgEndocrine: Effect on menstrual cycleTXAPA9 121,279,1993
intraperitoneal/hamster lowest published toxic dose: 150 mg/kgEndocrine: Change in gonadotropins

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TXAPA9 121,279,1993
intraperitoneal/hamster lowest published toxic dose: 75 mg/kgEndocrine: Other changesTXAPA9 121,279,1993
intraperitoneal/hamster lowest published toxic dose: 37.5 mg/kgEndocrine: Change in LH

Endocrine: Estrogenic
TXAPA9 121,279,1993
intraperitoneal/mouse lowest published toxic dose: 35 mg/kgBrain and Coverings: Other degenerative changesTXAPA9 93,319,1988
intraperitoneal/mouse lethal dose (50 percent kill): 71 mg/kgOYYAA2 1,78,1967
intraperitoneal/rat lethal dose (50 percent kill): 90 mg/kgPSDTAP 15,239,1974
intraperitoneal/rat lowest published toxic dose: 20 mg/kgNutritional and Gross Metabolic: Body temperature decreaseLSPPAT 23,2509,1978
intraperitoneal/rat lowest published toxic dose: 40 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationLSPPAT 23,2509,1978
intraperitoneal/rat lowest published toxic dose: 40 mg/kgEndocrine: Other changesTXAPA9 104,25,1990
intraperitoneal/rat lowest published toxic dose: 100 mg/kgEndocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hypofunction

Endocrine: Androgenic
TXAPA9 104,25,1990
intraperitoneal/rat lowest published toxic dose: 20 mg/kgEndocrine: Adrenal cortex hyperplasiaTXCYAC 69,257,1991
intraperitoneal/rat lowest published toxic dose: 50 mg/kgEndocrine: Change in gonadotropins

Blood: Other changes
TXCYAC 69,257,1991
intravenous/rat lowest published lethal dose: 60 mg/kgHBPTO* 1,881,2001
intravenous/rat lowest published toxic dose: 5 mg/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section
HBPTO* 1,881,2001
oral/mouse lethal dose (50 percent kill): 160 mg/kgSPEADM 78-1,21,1978
oral/rabbit lethal dose (50 percent kill): 625 mg/kg28ZEAL 5,43,1976
oral/rat lowest published toxic dose: 200 mg/kgEndocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 6,491,1992
oral/rat lethal dose (50 percent kill): 160 mg/kgKSKZAN 16(2),59,1978
skin/mouse lethal dose (50 percent kill): 225 mg/kgSPEADM 78-1,21,1978
skin/rabbit lethal dose (50 percent kill): 640 mg/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 263 mg/kgFAATDF 7,299,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/3D- intermittentBehavioral: Alteration of operant conditioningFAATDF 9,131,1987
oral/mouse lowest published toxic dose: 2184 mg/kg/104W- continuousBlood: TumorsHBPTO* 1,814,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,61,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,61,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWETOPFR 9,117,2001
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,544,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,96,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
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