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Registry of Toxic Effects of Chemical Substances (RTECS)

Formamide, N-methyl-

RTECS #

LQ3000000

CAS #

123-39-7

Updated

July 2011

Molecular Weight

59.08

Molecular Formula

C2H5NO

Synonyms

EK 7011
Methylformamide
Monomethylformamide
N-Methylformamide
NSC 3051
X 188

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mgTXAPA9 39,129,1977
eye /rabbit 100 µLHPV301 -,-,2004

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae500 mmol/L/3HEMMUEG 36,97,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 50 ppm (7-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV301 -,-,2004
intraperitoneal/rat 700 mg/kg (7-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
85DJA5 -,95,1971
oral/rat 1 gm/kg (7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
85DJA5 -,95,1971
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 27,239,1995
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 27,239,1995
oral/mouse 200 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 17,610,1967
oral/mouse 400 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)ARZNAD 17,610,1967
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 30,1557,1980
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ARZNAD 30,1557,1980
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system
FAATDF 27,239,1995
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
FAATDF 27,239,1995
oral/rat 1000 mg/kg (7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TPKVAL 9,163,1967
oral/rat 1000 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TPKVAL 9,163,1967
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV301 -,-,2004
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV301 -,-,2004
skin/rabbit 1800 mg/kg (8-16D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 41,35,1977
skin/mouse 400 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 17,610,1967
skin/mouse 800 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)ARZNAD 17,610,1967
skin/rat 1200 mg/kg (12-13D pregnant)Reproductive: Specific developmental abnormalities: Body wallTXAPA9 41,35,1977
skin/rat 400 mg/kg (12-13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 41,35,1977
skin/rat 600 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 41,35,1977
subcutaneous/mouse 70 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
DABBBA 40,549,1979
subcutaneous/rat 500 mg/kg (10D pregnant)Reproductive: Other developmental abnormalitiesAPEPA2 257,296,1967

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 391 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/rat lowest published toxic concentration: 5600 mg/m3/4HNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV301 -,-,2004
inhalation/rat lowest published toxic concentration: 10760 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV301 -,-,2004
intramuscular/mouse lethal dose (50 percent kill): 2700 mg/kgTXCYAC 34,173,1985
intraperitoneal/mouse lethal dose (50 percent kill): 802 mg/kgNCISP* JAN1986
intraperitoneal/rat lethal dose (50 percent kill): 3500 mg/kgJRPFA4 4,219,1962
intravenous/Dog Lethal dose: >568 mg/kgBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** PB82-232158
intravenous/mouse lethal dose (50 percent kill): 1580 mg/kgTXCYAC 34,173,1985
oral/mouse lethal dose (50 percent kill): 2600 mg/kgHPV301 -,-,2004
oral/mouse lethal dose (10 percent kill): 1800 mg/kgHPV301 -,-,2004
oral/rat lethal dose (50 percent kill): 2700 mg/kgCBINA8 148,1,2004
skin/rabbit lowest published lethal dose: 1500 mg/kgHPV301 -,-,2004
skin/rat lowest published lethal dose: 11000 mg/kgHPV301 -,-,2004
subcutaneous/mouse lethal dose (50 percent kill): 3100 mg/kgLung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
DABBBA 40,549,1979
subcutaneous/rat lethal dose (50 percent kill): >2500 mg/kgAPEPA2 257,296,1967
unreported route/guinea pig lethal dose (50 percent kill): 465 mg/kgEye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes
GISAAA 57(2),30,1992
unreported route/mouse lethal dose (50 percent kill): 1175 mg/kgEye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes
GISAAA 57(2),30,1992
unreported route/rat lethal dose (50 percent kill): 2400 mg/kgEye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes
GISAAA 57(2),30,1992
unreported route/rat lowest published toxic dose: 809 mg/kgLiver: Liver function tests impaired

Liver: Other changes
ARTODN 68,291,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 ppm/6H/2W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FAATDF 14,810,1990
inhalation/rat lowest published toxic concentration: 320 mg/m3/2W- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HPV301 -,,2004
inhalation/rat lowest published toxic concentration: 970 mg/m3/2W- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV301 -,,2004
intraperitoneal/mouse lowest published toxic dose: 4 gm/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 34,173,1985
intravenous/Dog lowest published toxic dose: 662 mg/kg/5D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NTIS** PB82-232158
intravenous/mouse lowest published toxic dose: 5603 mg/kg/5D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB82-232158
oral/rat lowest published toxic dose: 5460 µg/kg/26W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Cl
GISAAA 57(2),30,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDIMON* 39,678,1993

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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