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Registry of Toxic Effects of Chemical Substances (RTECS)

Ferric chloride

RTECS #

LJ9100000

CAS #

7705-08-0

Updated

December 2013

Molecular Weight

162.20

Molecular Formula

Cl3Fe

Synonyms

Chlorure perrique (French)
Flores martis
Iron chloride
Iron trichloride
Iron(III) chloride
Perchlorure de fer (French)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/human1 µmol/L/1HEMMUEG 38,1,2001
DNA Damageother cell types/human0.04 mmol/L/30MTCMUD8 20,11,2000
other mutation test systems/Escherichia coli500 nmol/tubeLAMEDS 6,252,1986
phage inhibition capacity/Escherichia coli41 ng/wellMUREAV 260,349,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 12976 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravaginal/rat 29 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)CCPTAY 4,91,1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration Low: 500 µmol/L/66HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.
TXCYAC 270,66,2010
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration Low: 200 µmol/L/66HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TXCYAC 270,66,2010
intracerebral/rat lowest published toxic dose: 0.324 mg/kgBrain and Coverings: Other degenerative changesNRTXDN 29,130,2008
intracerebral/rat lowest published toxic dose: 72 gm/kgBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
HETOEA 26,947,2007
intraperitoneal/mouse lethal dose (50 percent kill): 375 mg/kgVCVN5* -,431,1989
intraperitoneal/rat lethal dose (50 percent kill): 440 mg/kgVCVN5* -,431,1989
intravenous/mouse lethal dose (50 percent kill): 58 mg/kgYKKZAJ 87,677,1967
oral/mouse lethal dose (50 percent kill): 200 mg/kgNAYXEW 11,1,1991
oral/rat lethal dose (50 percent kill): 316 mg/kgNAYXEW 11,1,1991
oral/woman lowest published lethal dose: 4 mL/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
VHTODE 40,31,1998
subcutaneous/mouse lowest published toxic dose: 7.5 mg(Fe)/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,9,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7728 mg/kg/30W- continuousBehavioral: Fluid intake

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 39(5),16,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg(Fe)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWMUREAV 749,1,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Fe)/m3DTLVS* 3,138,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Fe)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit-KOREAtime-weighted average 1 mg(Fe)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg(Fe)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg(Fe)/m3;short term exposure limit 2 mg(Fe)/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X6846; Number of Industries 1; Total Number of Facilities 39; Number of Occupations 1; Total Number of Employees Exposed 39
National Occupational Exposure Survey 1983Hazard Code 33160; Number of Industries 70; Total Number of Facilities 5021; Number of Occupations 79; Total Number of Employees Exposed 108492; Total Number of Female Employees Exposed 52117
National Occupational Hazard Survey 1974Hazard Code 33160; Number of Industries 51; Total Number of Facilities 3137; Number of Occupations 37; Total Number of Employees Exposed 27934

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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