CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ferric chloride

RTECS #: LJ9100000

CAS #: 7705-08-0


UPDATE: May 2009 MW: 162.20 MF: Cl3Fe


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Chlorure perrique (French)
  2. Flores martis
  3. Iron chloride
  1. Iron trichloride
  2. Iron (III) chloride
  3. Perchlorure de fer (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human other cell types 1 µmol/L/1 hour EMMUEG 38,1,2001
DNA damage human other cell types 0.4 mmol/L/30 minute TCMUD8 20,11,2000
other mutation test systems Escherichia coli 500 nmol/tube LAMEDS 6,252,1986
phage inhibition capacity Escherichia coli 41 ng/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 12,976 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravaginal
rat
lowest published toxic dose: 29 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 4,91,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lowest published toxic dose: 0.324 mg/kg Brain and Coverings: Other degenerative changes NRTXDN 29,130,2008
intraperitoneal
mouse
lethal dose (50 percent kill): 375 mg/kg N/R VCVN5* -,431,1989
intraperitoneal
rat
lethal dose (50 percent kill): 440 mg/kg N/R VCVN5* -,431,1989
intravenous
mouse
lethal dose (50 percent kill): 58 mg/kg N/R YKKZAJ 87,677,1967
oral
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NAYXEW 11,1,1991
oral
rat
lethal dose (50 percent kill): 316 mg/kg N/R NAYXEW 11,1,1991
oral
woman
lowest published lethal dose: 4 mL/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
VHTODE 40,31,1998
subcutaneous
mouse
lowest published toxic dose: 7.5 mg(Fe)/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,9,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,728 mg/kg/30 week- continuous Behavioral: Fluid intake

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 39(5),16,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg(Fe)/m3 DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Fe)/m3 DTLVS* 3,138,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Fe)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - KOREA time-weighted average 1 mg(Fe)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg(Fe)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(Fe)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg(Fe)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg(Fe)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33160;
Number of Industries 51;
Total Number of Facilities 3,137;
Number of Occupations 37;
Total Number of Employees Exposed 27,934
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6846;
Number of Industries 1;
Total Number of Facilities 39;
Number of Occupations 1;
Total Number of Employees Exposed 39
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33160;
Number of Industries 70;
Total Number of Facilities 5,021;
Number of Occupations 79;
Total Number of Employees Exposed 108,492;
Total Number of Female Employees Exposed 52,117


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in sewage and drinking water treatments, etchant for photoengraving and rotogravure
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
LAMEDS LARC Medical. (19 bis, rue d'Inkermann, 59000 Lille, France) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAYXEW Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used in sewage and drinking water treatments, etchant for photoengraving and rotogravure

NIOSH PROFILE (IRON AND ITS COMPOUNDS), SRC, 3/82

NIOSH PROFILE (PRINTING INDUSTRY), SRC, 10/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us