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Ethylene, chloro -

RTECS #: KU9625000

CAS #: 75-01-4


UPDATE: May 2009 MW: 62.50 MF: C2H3Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Chloroethene
  2. Chloroethylene
  3. Chlorure de vinyle (French)
  4. Cloruro di vinile (Italian)
  5. Ethene, chloro -
  6. Ethylene monochloride
  7. Monochloroethene
  8. Monochloroethylene
  9. RCRA waste number U043
  1. VCM
  2. Vinile (cloruro di) (Italian)
  3. Vinyl C monomer
  4. Vinyl chloride
  5. Vinyl chloride (ACGIH:OSHA)
  6. Vinyl chloride monomer
  7. Vinylchlorid (German)
  8. Vinyle (chlorure de) (French)
  9. Winylu chlorek (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis inhalation
hamster
12,500 ppm/6 hour ARTODN 45,1,1980
cytogenetic analysis multiple
hamster
600 mg/kg MUREAV 53,187,1978
cytogenetic analysis hamster lung 5 pph/6 hour (+enzymatic activation step) MUREAV 652,122,2008
cytogenetic analysis human HeLa cell 10 mmol/L TXCYAC 9,21,1978
cytogenetic analysis inhalation
rat
150 g/m3/14 week- continuous GISAAA 43(7),111,1978
DNA adduct oral
rat
18 gm/kg/2 year- continuous CBINA8 22,211,1978
DNA damage inhalation
rat
205 ppm/5 hour CBINA8 37,219,1981
DNA inhibition intravenous
rat
9,500 g/kg CBINA8 17,239,1977
DNA repair Escherichia coli 100 g/plate MUREAV 54,101,1978
unscheduled DNA synthesis rat liver 2,100 mol/L CRNGDP 5,1629,1984
host-mediated assay mouse
Schizosaccharomyces pombe
700 mg/kg MUREAV 40,85,1976
host-mediated assay mouse
Saccharomyes cerevisiae
700 mg/kg TOERD9 3,131,1981
host-mediated assay rat
Saccharomyes cerevisiae
1 pph/24 hour- continuous MUREAV 91,381,1981
mutation in microorganisms Escherichia coli 10,600 mol/L (+enzymatic activation step) BCPCA6 24,2013,1975
mutation in microorganisms hamster lung 20 pph/5 hour (+enzymatic activation step) MUREAV 67,173,1979
mutation in microorganisms Salmonella typhimurium 2,000 ppm/48 hour (+enzymatic activation step) BBRCA9 63,363,1975
mutation in microorganisms Salmonella typhimurium 1 pph (-enzymatic activation step) CBTOE2 1(3),159,1985
mutation in microorganisms Salmonella typhimurium 50 pph TOXID9 66,37,2002
mutation in microorganisms Schizosaccharomyces pombe 16 mmol/L/30 minute (+enzymatic activation step) MUREAV 40,85,1976
micronucleus test hamster embryo 30 pph MUREAV 203,397,1988
micronucleus test inhalation
mouse
5 pph/4 hour MUREAV 75,191,1980
gene conversion and mitotic recombination Saccharomyes cerevisiae 48 mmol/L/3 hour MUREAV 40,85,1976
mutation in mammalian somatic cells hamster ovary 10 pph EVSRBT 25,91,1982
mutation in mammalian somatic cells human lymphocyte 7,500 ppt CRNGDP 18,31,1997
morphological transform mouse embryo 75 mg/L CALEDQ 28,85,1985
morphological transform inhalation
rat
2,000 ppm/14 week- intermittent ARTODN 47,71,1981
sister chromatid exchange inhalation
hamster
12,500 ppm/6 hour ARTODN 45,1,1980
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
1 pph MUREAV 57,307,1978
specific locus test inhalation
Drosophila melanogaster
48,500 ppm CRNGDP 17,1083,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 30 mg/m3 (5 year male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GTPZAB 24(5),28,1980
inhalation
mouse
lowest published toxic concentration: 30,000 ppm/6 hour (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EVHPAZ 21,71,1977
inhalation
mouse
lowest published toxic concentration: 500 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 41,171,1981
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (26 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EESADV 10,281,1985
inhalation
rat
lowest published toxic concentration: 500 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 33,134,1975
inhalation
rat
lowest published toxic concentration: 1,500 ppm/24 hour (1-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXCYAC 11,45,1978
inhalation
rat
lowest published toxic concentration: 500 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 41,171,1981
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour (55 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JTEHD6 3,965,1977
inhalation
rabbit
lowest published toxic concentration: 500 ppm/7 hour (6-18 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 41,171,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 50 ppm/4 hour/30 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
APDCDT 3,216,1976
inhalation
human
toxic concentration (other than lowest) : 300 mg/m3/1 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
GTPZAB 26(1),28,1982
inhalation
man
lowest published toxic concentration: 200 ppm/14 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
VAPHDQ 372,195,1976
inhalation
mouse
lowest published toxic concentration: 50 ppm/30 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Skin and Appendages: Tumors
ANYAA9 271,431,1976
inhalation
mouse
toxic concentration (other than lowest) : 50 ppm/47 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JTEHD6 4,15,1978
inhalation
mouse
toxic concentration (other than lowest) : 50 ppm/6 hour/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JTEHD6 7,909,1981
inhalation
mouse
toxic concentration (other than lowest) : 50 ppm/4 hour/30 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
CSHCAL 4,119,1977
inhalation
rat
lowest published toxic concentration: 1 ppm/4 hour/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
EVHPAZ 41,3,1981
inhalation
rat
lowest published toxic concentration: 10,000 ppm/4 hour (12-18 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Endocrine: Tumors
CSHCAL 4,119,1977
inhalation
rat
toxic concentration (other than lowest) : 50 ppm/7 hour/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Skin and Appendages: Tumors
TXAPA9 68,120,1983
inhalation
rat
toxic concentration (other than lowest) : 100 ppm/7 hour/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
TXAPA9 68,120,1983
inhalation
rat
toxic concentration (other than lowest) : 250 ppm/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Ear: Tumors

Liver: Angiosarcoma
AANLAW 56,1,1974
inhalation
rat
toxic concentration (other than lowest) : 5 ppm/4 hour/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
EVHPAZ 41,3,1981
inhalation
rat
toxic concentration (other than lowest) : 50 ppm/6 hour/43 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
JTEHD6 7,909,1981
inhalation
rat
lowest published toxic concentration: 128 mg/m3/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Angiosarcoma
VCVGH* -,422,1990
inhalation
rat
lowest published toxic concentration: 77,000 mg/m3/6 minute Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Lung, Thorax, or Respiration: Tumors
VCVGH* -,422,1990
intraperitoneal
rat
lowest published toxic dose: 21 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Gastrointestinal: Tumors
APDCDT 3,216,1976
oral
rat
lowest published toxic dose: 3,463 mg/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
EVHPAZ 41,3,1981
oral
rat
toxic dose : 34 gm/kg/3 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Angiosarcoma

Kidney, Ureter, and Bladder: Kidney tumors
EVHPAZ 21,1,1977
subcutaneous
rat
lowest published toxic dose: 21 mg/kg/67 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
APDCDT 3,216,1976


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 517,000 mg/m3/1 hour Behavioral: General anesthetic VCVGH* -,420,1990
inhalation
dog
lowest published lethal concentration: 1,034,000 mg/m3/4 hour N/R VCVGH* -,420,1990
inhalation
dog
lethal concentration (50 percent kill): 260,000 mg/m3 N/R VCVGH* -,420,1990
inhalation
guinea pig
lowest published lethal concentration: 30 pph/30 minute Behavioral: General anesthetic AIHAAP 21,394,1960
inhalation
guinea pig
lowest published toxic concentration: 258,000 mg/m3/90 minute Behavioral: General anesthetic VCVGH* -,420,1990
inhalation
guinea pig
lowest published lethal concentration: 1,552,000 mg/m3/18 minute N/R VCVGH* -,420,1990
inhalation
human
lowest published toxic concentration: 1,320 mg/m3/7 hour Behavioral: Headache VCVGH* -,421,1990
inhalation
human
lowest published toxic concentration: 16,000 mg/m3/5 minute Ear: Change in acuity

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGH* -,421,1990
inhalation
mammal (species unspecified)
lowest published lethal concentration: 200 ppm/18 minute N/R IPSTB3 3,93,1976
inhalation
mouse
lowest published lethal concentration: 20 pph/30 minute Behavioral: General anesthetic AIHAAP 21,394,1960
inhalation
mouse
lowest published lethal concentration: 1,056,000 mg/m3/15 minute N/R VCVGH* -,420,1990
inhalation
mouse
lowest published lethal concentration: 185,000 mg/m3/1 hour N/R VCVGH* -,420,1990
inhalation
rat
lethal concentration (50 percent kill): 18 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R DOWCC*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 30 mg/m3/4 hour/26 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP
GTPZAB 16(2),24,1972
inhalation
rat
lowest published toxic concentration: 5,000 ppm/7 hour/52 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
TXCYAC 13,25,1979
inhalation
rat
lowest published toxic concentration: 400 mg/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight
GISAAA 44(11),74,1979
inhalation
rat
lowest published toxic concentration: 28,000 ppm/7 hour/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 62,1,1982
inhalation
rat
lowest published toxic concentration: 2,000 ppm/8 hour/92 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count
AIHAAP 24,265,1963
inhalation
rat
lowest published toxic concentration: 30 mg/m3/4 hour/20 day- intermittent Cardiac: EKG changes not diagnostic of above VCVGH* -,422,1990
inhalation
rat
lowest published toxic concentration: 30 mg/m3/4 hour/18 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction) VCVGH* -,422,1990
inhalation
rat
lowest published toxic concentration: 300 mg/m3/4 hour/28 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic VCVGH* -,422,1990
inhalation
rat
lowest published toxic concentration: 1,100 ppm/4 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,158,2001
inhalation
rabbit
lowest published toxic concentration: 9 gm/m3/4 hour/22 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP
GTPZAB 12(7),47,1968
inhalation
rabbit
lowest published toxic concentration: 30 mg/m3/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Musculoskeletal: Osteoporosis
GTPZAB 16(2),24,1972
inhalation
rabbit
lowest published toxic concentration: 30 mg/m3/4 hour/4 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Musculoskeletal: Other changes
VCVGH* -,422,1990
inhalation
rabbit
lowest published toxic concentration: 900 mg/m3/8 week- continuous Cardiac: EKG changes not diagnostic of above

Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow
VCVGH* -,422,1990
oral
mouse
lowest published toxic dose: 75 mg/kg/3 day- intermittent Liver: Other changes

Liver: Changes in liver weight
TXCYAC 249,176,2008
oral
rat
lowest published toxic dose: 23,400 mg/kg/13 week- intermittent Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTXAV 13,633,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 19,377,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 19,377,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,373,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
JTEHD6 1,47,1975
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
CHWEAP 70(28/29),5,1974
TOXICOLOGY REVIEW
CANCAR 39,1792,1977
TOXICOLOGY REVIEW
MUREAV 32,93,1975
TOXICOLOGY REVIEW
ZHPMAT 166,113,1978
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
ABMHAM 35,585,1977
TOXICOLOGY REVIEW
CBINA8 22,117,1978
TOXICOLOGY REVIEW
GTPZAB 20(4),46,1976
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
MUREAV 41,131,1976
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,546,2005
TOXICOLOGY REVIEW
ENTOX* -,438,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 531,1,2003
TOXICOLOGY REVIEW
MUREAV 531,217,2003
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
JTPAE7 18,69,2005
TOXICOLOGY REVIEW
MUREAV 544,313,2003
TOXICOLOGY REVIEW
MUREAV 608,136,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (510 mg/m3) DTLWS* 3,31,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1117 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (13 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1017,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2.5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (13 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 5 mg/m3 (2 mL/m3), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 8 mg/m3 (3 mL/m3) (production), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 3 ppm (7.77 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 7.77 mg/m3 (3 ppm), APR 2004
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (15 mg/m3), short term exposure limit 10 ppm (30 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 1 ppm (2.59 mg/m3), continuous1 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 10 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 2.5 ppm (6.5 mg/m3), group 1 carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 1 ppm, carcinogen, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (13 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7.77 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (13 mg/m3), carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 5 mg/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (2.5 mg/m3);
short term exposure limit 5 ppm (13 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (5.2 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (1300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL CHLORIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76445;
Number of Industries 22;
Total Number of Facilities 1,459;
Number of Occupations 36;
Total Number of Employees Exposed 29,836
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76445;
Number of Industries 63;
Total Number of Facilities 3,711;
Number of Occupations 59;
Total Number of Employees Exposed 81,314;
Total Number of Female Employees Exposed 28,398


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101132/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte; E coli polA with S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Mouse spot test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of VINYL CHLORIDE homopolymer and copolymer resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 28, 1978
NIOSH Analytical Method, 1994: Vinyl chloride, 1007
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #04


REFERENCES:

CODEN
REFERENCE

AANLAW Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti. (Academia Nazionale dei Lincei, Via della Lungara, 10, I-00165 Rome, Italy) 1892-1939; Ser. 8: V.1- 1946-
ABMHAM Archives Belges de Medecine Sociale, Hygiene, Medecine du Trevail et Medecine Legale. (Quartier Esplanade no.6, 1010 Brussels, Belgium) V.4- 1946-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APDCDT Advances in Tumour Prevention, Detection and Characterization. (New York, NY) V.1-5, 1974-80. Discontinued.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHWEAP Chemisch-Weekblad. (The Hague, Netherlands) V.1-71, 1903-75.
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Used in the production of VINYL CHLORIDE homopolymer and copolymer resins

Top 50 chemical production: 13.23 billions lbs in 1992, 11.70 billions in 1991

NIOSH PROFILE (PETROCHEMICAL PLANTS), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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