CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ethylene

RTECS #: KU5340000

CAS #: 74-85-1


UPDATE: February 2009 MW: 28.06 MF: C2H4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acetene
  2. Athylen (German)
  3. Bicarburretted hydrogen
  4. Elayl
  1. Ethene
  2. Ethylene (ACGIH:OSHA)
  3. Liquid ethyene
  4. Olefiant gas


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published lethal concentration: 950,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
mouse
lethal concentration (50 percent kill): 95 ppm/2 hour N/R VCVGH* -,46,1990
inhalation
mouse
lowest published toxic concentration: 350,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,46,1990
inhalation
rat
lowest published toxic concentration: 1,000 ppm/2 hour Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
NSAPCC 375(Suppl 1),74,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,157,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,157,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,45,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 60,45,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,45,1994
TOXICOLOGY REVIEW
CLPTAT 8,91,1967
TOXICOLOGY REVIEW
TOLED5 138,1,2003
TOXICOLOGY REVIEW
ENTOX* -,271,2005
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
MUREAV 658,215,2008
TOXICOLOGY REVIEW
MUREAV 544,313,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,254,1998
Mine Safety and Health Administration (MSHA) STANDARD ASPHYXIANTS/GASES DTLWS* 3,19,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)simple asphyxiant inert gases and vapors CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) Simple asphyxiants - inert gas and vapor CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (233 mg/m3), Asphyxiant, MAR2002
Occupational Exposure Limit - MEXICO Simple asphyxiant, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 330 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND Simple asphyxiant, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 250 ppm (300 mg/m3);
short term exposure limit 1000 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10000 ppm (11500 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81826;
Number of Industries 25;
Total Number of Facilities 1,071;
Number of Occupations 43;
Total Number of Employees Exposed 27,450
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81826;
Number of Industries 7;
Total Number of Facilities 568;
Number of Occupations 22;
Total Number of Employees Exposed 12,282;
Total Number of Female Employees Exposed 2,363


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of fabricated plastics, antifreeze, fruit ripener, anesthetic and fibers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of fabricated plastics, antifreeze, fruit ripener, anesthetic and fibers

Top 50 chemical production: 40.41 billions lbs in 1992, 39.96 billions in 1991

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen

ALT CAS #: 33060-30-9
ALT CAS #: 87701-64-2
ALT CAS #: 87701-65-3
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us