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Ether, fluoromethyl 2,2,2 - trifluoro - 1 - (trifluoromethyl) ethyl -

RTECS #: KO0737000

CAS #: 28523-86-6


UPDATE: May 2009 MW: 200.07 MF: C4H3F7O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. REFERENCES:

SYNONYMS:

  1. 1,1,1,3,3,3 - Hexafluoro - 2 - (fluoromethoxy) propane
  2. Fluoromethyl 2,2,2 - trifluoro - 1 - (trifluoromethyl) ethyl ether
  3. Fluoromethyl - 1,1,1,3,3,3 - hexafluoro - 2 - propyl ether
  4. MR6S4
  1. Propane, 1,1,1,3,3,3 - hexafluoro - 2 - (fluoromethoxy) - (9CI)
  2. SVF
  3. Sevoflurane
  4. Ultane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage inhalation
human
1 pph/2 hour MUREAV 492,99,2001
DNA damage inhalation
rabbit
3 pph/2 day/2 hour- intermittent HETOEA 23,413,2004
micronucleus test oral
rat
4 mmol/kg MUREAV 413,1,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 6,600 ppm/3 hour (64 day male/14 day prior to copulation) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands KSRNAM 21,5505,1987
inhalation
rat
lowest published toxic concentration: 2 pph/3 hour (9 week male/2 week prior to copulation/1-7 day pregnant) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) KSRNAM 21,5505,1987
inhalation
rat
lowest published toxic concentration: 1 pph/3 hour (9 week male/2 week prior to copulation/1-7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 21,5505,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
child
lowest published toxic concentration: 2.5 pph Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Metabolism (intermediary): Other
AANEAB 45,639,2001
inhalation
child
lowest published toxic concentration: 8 pph Brain and Coverings: Changes in surface EEG

Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section
AANEAB 45,805,2001
inhalation
mouse
lethal concentration (50 percent kill): 28,300 ppm/3 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair
KSRNAM 21,5497,1987
inhalation
pig
lowest published toxic concentration: 4 pph/6 hour Cardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes
AANEAB 46,1137,2002
inhalation
pig
lowest published toxic concentration: 4 pph/6 hour Lung, Thorax, or Respiration: Other changes AANEAB 46,1137,2002
inhalation
rat
lethal concentration (50 percent kill): 28,800 ppm/3 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair
KSRNAM 21,5497,1987
inhalation
rat
lethal concentration : 1.5 pph/10 minute Spinal Cord: Other degenerative changes

Behavioral: Analgesia
LIFSAK 71,571,2002
inhalation
rat
lowest published toxic concentration: 2 pph/30 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other
AANEAB 46,378,2002
inhalation
woman
lowest published toxic concentration: 1 pph/3 hour Vascular: Other changes AANEAB 46,481,2002
intraperitoneal
mouse
lethal dose (50 percent kill): 10,500 mg/kg N/R NIIRDN -,591,1990
intraperitoneal
rat
lethal dose (50 percent kill): 6,300 mg/kg N/R NIIRDN -,591,1990
oral
mouse
lethal dose (50 percent kill): 18,200 mg/kg N/R NIIRDN -,591,1990
oral
rat
lethal dose (50 percent kill): 10,800 mg/kg N/R NIIRDN -,591,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TPHSDY 23,519,2002
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,125,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (80 mg/m3);
short term exposure limit 20 ppm (170 mg/m3), JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTOX*
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

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   Reproductive Effector
   Human Data

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