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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-

RTECS #

KO0737000

CAS #

28523-86-6

Updated

December 2013

Molecular Weight

200.07

Molecular Formula

C4H3F7O

Synonyms

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
Fluoromethyl-1,1,1,3,3,3-hexafluoro-2-propyl ether
MR6S4
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI)
Sevoflurane
SVF
Ultane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageinhalation/human1 pph/2HMUREAV 492,99,2001
DNA Damageinhalation/rabbit3 pph/2H/2D- intermittentHETOEA 23,413,2004
DNA Damageinhalation/woman1.25 pph/120MTIHEEC 25,205,2009
micronucleus testoral/rat4 mmol/kgMUREAV 413,1,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 6600 ppm/3H (64D male/14D prior to copulation)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsKSRNAM 21,5505,1987
inhalation/rat 2 pph/3H (9W male/2W prior to copulation/1-7D pregnant)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)KSRNAM 21,5505,1987
inhalation/rat 1 pph/3H (9W male/2W prior to copulation/1-7D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemKSRNAM 21,5505,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/maaInhibitor Concentration Low: 0.92 mmol/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 250,291,2011
inhalation/child lowest published toxic concentration: 2.5 pphCardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Metabolism (intermediary): Other
AANEAB 45,639,2001
inhalation/child lowest published toxic concentration: 8 pphBrain and Coverings: Changes in surface EEG

Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section
AANEAB 45,805,2001
inhalation/mouse lethal concentration (50 percent kill): 28300 ppm/3HBehavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair
KSRNAM 21,5497,1987
inhalation/pig lowest published toxic concentration: 4 pph/6HCardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes
AANEAB 46,1137,2002
inhalation/pig lowest published toxic concentration: 4 pph/6HLung, Thorax, or Respiration: Other changesAANEAB 46,1137,2002
inhalation/rat lowest published toxic concentration: 3 pphBrain and Coverings: Other degenerative changesFCLPH* 22(Suppl 1),2,2008
inhalation/rat Lowest published lethal concentration: 1.5 pph/10MSpinal Cord: Other degenerative changes

Behavioral: Analgesia
LIFSAK 71,571,2002
inhalation/rat lethal concentration (50 percent kill): 28800 ppm/3HBehavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair
KSRNAM 21,5497,1987
inhalation/rat lowest published toxic concentration: 2 pph/30MBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other
AANEAB 46,378,2002
inhalation/woman lowest published toxic concentration: 1 pph/3HVascular: Other changesAANEAB 46,481,2002
intraperitoneal/mouse lethal dose (50 percent kill): 10500 mg/kgNIIRDN -,591,1990
intraperitoneal/mouse lowest published toxic dose: 1.4 mL/kgBehavioral: Altered sleep time (including change in righting reflex)BCLPT* 103,31,2008
intraperitoneal/mouse lowest published toxic dose: 0.7 mL/kgBehavioral: AnalgesiaBCLPT* 103,31,2008
intraperitoneal/rat lethal dose (50 percent kill): 6300 mg/kgNIIRDN -,591,1990
oral/mouse lethal dose (50 percent kill): 18200 mg/kgNIIRDN -,591,1990
oral/rat lethal dose (50 percent kill): 10800 mg/kgNIIRDN -,591,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTPHSDY 23,519,2002
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWENTOX* -,125,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (83 mg/m3), short term exposure limit 20 ppm (170 mg/m3), NOV2011
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (80 mg/m3);short term exposure limit 20 ppm (170 mg/m3), JUN2005
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