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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, 2,4-dichlorophenyl p-nitrophenyl

RTECS #

KN8400000

CAS #

1836-75-5; 51274-07-8

Updated

October 2011

Molecular Weight

284.10

Molecular Formula

C12H7Cl2NO3

Synonyms

2,4-Dechlorophenyl p-nitrophenyl ether
2,4-Dichloro-1-(4-nitrophenoxy)benzene
2',4'-Dichloro-4-nitrobiphenyl ether
2,4-Dichloro-4'-nitrodiphenyl ether
2,4-Dichlorophenyl 4-nitrophenyl ether
2,4-Dichlorophenyl p-nitrophenyl ether
2,4-Dichlorphenyl-4-nitrophenylaether (German)
4-(2,4-Dichlorophenoxy)nitrobenzene
4'-Nitro-2,4-dichlorodiphenyl ether
Benzene, 2,4-dichloro-1-(4-nitrophenoxy)-
FW 925
Mezotox
NCI-C00420
NE
Niclofen
NIP
Nitofen
Nitrafen
Nitraphen
Nitrochlor
Nitrofen
Nitrofene (French)
Nitrophen
Nitrophene
Preparation 125
TOK
TOK E
TOK E 40
TOK E-25
TOK WP-50
TOK-2
Tokkorn
Trizilin
Trizilin 25

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat1500 ng/plateJJATDK 1,190,1981
mutation in microorganisms/Salmonella typhimurium33300 ng/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
phage inhibition capacity/Escherichia coli4460 µmol/LMUREAV 182,193,1987
phage inhibition capacity/Escherichia coli35.7 mmol/L (+enzymatic activation step)EMMUEG 36,206,2000
sister chromatid exchangelung/hamster12.5 µmol/L/32HMUREAV 580,41,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 23 mg/m3 (2-5D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Urogenital system
VCVGK* -,312,1994
oral/rat 825 mg/kg (8-18D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathVCVGK* -,313,1994
oral/rat 1650 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,313,1994
oral/rat 550 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Specific developmental abnormalities: Respiratory system
VCVGK* -,313,1994
oral/rat 250 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemTXAPA9 73,323,1984
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Body wallNTIS** #PB84-193879
oral/rat 62500 µg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
JACTDZ 4(1),221,1985
oral/rat 150 mg/kg (7-12D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)TCMUD8 6,339,1986
oral/rat 37530 µg/kg (6-18D pregnant)Reproductive: Effects on newborn: PhysicalTXCYAC 34,285,1985
oral/rat 62500 µg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 34,213,1986
oral/rat 100 mg/kg (11D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXCYAC 20,209,1981
oral/rat 80 mg/kg (10-13D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXAPA9 86,22,1986
oral/mouse 660 mg/kg (5-15D pregnant)Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TJADAB 24(1),11A,1981
oral/mouse 1100 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
SCIEAS 215,293,1982
oral/mouse 660 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Physical
NMJOAA 31,115,1986
oral/mouse 68750 µg/kg (7-17D pregnant)Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Physical
TXAPA9 67,1,1983
oral/mouse 550 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TXAPA9 67,1,1983
oral/mouse 2520 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TJADAB 32,45B,1985
skin/mouse 175 mg/kg (8D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsJPFCD2 21,303,1986
skin/mouse 160 mg/kg (8D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TXCYAC 40,297,1986
skin/mouse 286 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemJPFCD2 21,303,1986
skin/mouse 1100 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TJADAB 25(2),45A,1982
skin/rat 12 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Respiratory system
TXCYAC 28,37,1983
skin/rat 120 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 28,37,1983
skin/rat 120 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 28,37,1983
unreported route/rat 13900 µg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Body wallTJADAB 25(2),45A,1982
unreported route/rat 125 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 25(2),45A,1982
unreported route/rat 220 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Respiratory systemPHMCAA 19,178,1977
unreported route/rat 352 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)PHMCAA 19,178,1977
unreported route/mouse 550 mg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 25(2),45A,1982
unreported route/mouse 1100 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TJADAB 25(2),45A,1982
unreported route/hamster 500 mg/kg (7-11D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 25(2),45A,1982
unreported route/rat 37.53 mg/kg (8-16D pregnant)Reproductive: Other developmental abnormalitiesHBPTO* 1,740,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 24 gm/kg/12W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Lung, Thorax, or Respiration: Tumors
JJIND8 65,937,1980
oral/mouse toxic dose: 200 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
NCITR* NCI-TR-184,1979
oral/mouse toxic dose: 308 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
NCITR* NCI-TR-26,1978
oral/mouse toxic dose: 114 gm/kg/58W- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
NCITR* NCI-TR-26,1978
oral/mouse toxic dose: 47 gm/kg/12W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Lung, Thorax, or Respiration: Tumors
JJIND8 65,937,1980
oral/rat lowest published toxic dose: 42 gm/kg/94W- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
NCITR* NCI-TR-26,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 620 mg/m3/4HBehavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
HYSAAV 32(1),20,1967
oral/cat lowest published lethal dose: 300 mg/kgHYSAAV 32(1),20,1967
oral/mouse lethal dose (50 percent kill): 450 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
HYSAAV 32(1),20,1967
oral/mouse lethal dose (50 percent kill): 8250 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea
VCVGK* -,312,1984
oral/rabbit lethal dose (50 percent kill): 2650 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea
VCVGK* -,312,1984
oral/rabbit lethal dose (50 percent kill): 1620 mg/kg28ZEAL 5,166,1976
oral/rat lethal dose (50 percent kill): 740 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
HYSAAV 32(1),20,1967
oral/rat lowest published toxic dose: 250 mg/kgEndocrine: Other changes

Endocrine: Evidence of thyroid hypofunction
TXAPA9 73,323,1984
oral/rat lethal dose (50 percent kill): 7850 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea
VCVGK* -,312,1984
oral/woman lowest published lethal dose: 10 mL/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
VHTODE 43,212,2001
skin/rabbit lowest published lethal dose: 3270 mg/kgTXCYAC 29,1,1983
skin/rat lethal dose (50 percent kill): 5 gm/kgAEHLAU 28,316,1974
unreported route/rat lethal dose (50 percent kill): 3 gm/kg30ZDA9 -,109,1971
unreported route/rat lowest published toxic dose: 250 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)HBPTO* 1,740,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 26 mg/m3/4H/7W- intermittentBlood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 32(1),19,1967
inhalation/mammal (species unspecified) lowest published toxic concentration: 18 mg/m3/4H/122D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,313,1994
oral/Dog lowest published toxic dose: 1400 mg/kg/4W- continuousLiver: Changes in liver weightTXAPA9 19,263,1971
oral/Dog lowest published toxic dose: 36400 mg/kg/2Y- continuousLiver: Changes in liver weightFCTXAV 10,427,1972
oral/rat lowest published toxic dose: 13650 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 19,263,1971
oral/rat lowest published toxic dose: 40740 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTXAV 10,427,1972
oral/rat lowest published toxic dose: 40740 mg/kg/97W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 19,263,1971
oral/rat lowest published toxic dose: 68320 mg/kg/305D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGK* -,313,1994
unreported route/rat lowest published toxic dose: 1500 mg/kg/3D- continuousEndocrine: Evidence of thyroid hyperfunctionHBPTO* 1,740,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 30,271,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,271,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWAPLMAS 107,54,1983
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 627,59,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWREPTED 31,392,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-184,1979
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-26,1978
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-184,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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