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Ether, 1 - chloro - 2,2,2 - trifluoroethyl difluoromethyl

RTECS #: KN6799000

CAS #: 26675-46-7

UPDATE: May 2009 MW: 184.50 MF: C3H2ClF5O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (+ - ) - Isoflurane
  2. 2 - Chloro - 2 - (difluoromethoxy) - 1,1,1 - trifluoroethane
  3. Ethane, 2 - chloro - 2 - (difluoromethoxy) - 1,1,1 - trifluoro - (9CI)
  4. Forane
  1. ISF
  2. Isoflurane
  3. Pentafluoran
  4. R - E 235dal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage inhalation
human 		1 pph/2 hour MUREAV 492,99,2001
DNA damage inhalation
rat 		1 pph/30 minute TXCYAC 220,169,2006
micronucleus test oral
rat 		4 mmol/kg MUREAV 413,1,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 6,000 ppm/4 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 29(2),54A,1984
inhalation
rat 		lowest published toxic concentration: 10,500 ppm/6 hour (14-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANESAV 64,339,1986
inhalation
rat 		lowest published toxic concentration: 4,000 ppm/3 hour (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) KSRNAM 21,3091,1987
inhalation
rat 		lowest published toxic dose: 12,000 ppm/3 hour (17-20 day pregnant/21 day after birth) Reproductive: Effects on newborn: Physical KSRNAM 21,3109,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1.8 pph Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes 		AANEAB 45,971,2001
inhalation
mouse 		lethal concentration (50 percent kill): 16,800 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 21,3031,1987
inhalation
mouse 		lethal concentration (16 percent kill): 35.3 gm/m3/2 hour Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (5),12,1998
inhalation
mouse 		lethal concentration (50 percent kill): 50.5 gm/m3/2 hour Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (5),12,1998
inhalation
mouse 		lowest published toxic concentration: 1.27 pph/6 minute Behavioral: Analgesia JPETAB 317,615,2006
inhalation
rat 		lethal concentration (50 percent kill): 15,300 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 21,3031,1987
inhalation
rat 		lowest published toxic concentration: 1 pph/30 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other 		AANEAB 46,378,2002
inhalation
rat 		lowest published toxic concentration: 1.2 pph/30 minute Behavioral: Analgesia AANEAB 46,451,2002
inhalation
rat 		lowest published toxic concentration: 1 pph/90 minute Brain and Coverings: Other degenerative changes EJPHAZ 503,49,2004
inhalation
rat 		lethal concentration (16 percent kill): 35.2 gm/m3/4 hour Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (5),12,1998
inhalation
rat 		lethal concentration (50 percent kill): 58.5 gm/m3/4 hour Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (5),12,1998
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,030 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
intraperitoneal
mouse 		lowest published lethal dose: 60,000 mg/kg N/R TOVEFN (5),12,1998
intraperitoneal
rat 		lethal dose (50 percent kill): 4,280 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
intraperitoneal
rat 		lethal dose (16 percent kill): 10,250 mg/kg N/R TOVEFN (5),12,1998
intraperitoneal
rat 		lethal dose (50 percent kill): 14,400 mg/kg N/R TOVEFN (5),12,1998
intraperitoneal
rat 		lethal dose : 20,200 mg/kg N/R TOVEFN (5),12,1998
oral
man 		lowest published lethal dose: 1,143 無/kg Brain and Coverings: Changes in surface EEG

Behavioral: Muscle weakness

Blood: Changes in leukocyte (WBC) count 		NLJMAV 33,74,1988
oral
man 		lowest published lethal dose: 1,071 無/kg N/R JFSCAS 38,968,1993
oral
mouse 		lethal dose (50 percent kill): 5,080 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987
oral
rat 		lethal dose (50 percent kill): 4,770 無/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		KSRNAM 21,3031,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 1,500 ppm/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ANESAV 42,408,1975
inhalation
mouse 		lowest published toxic concentration: 150 ppm/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ANESAV 42,408,1975
inhalation
rat 		lowest published toxic concentration: 12,000 ppm/3 hour/10 week- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 21,3037,1987
inhalation
rat 		lowest published toxic concentration: 24 gm/m3/3 day- intermittent Biochemical: Metabolism (intermediary): Other TOVEFN (5),12,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMSUDL 7,93,1987
TOXICOLOGY REVIEW
TPHSDY 23,519,2002
TOXICOLOGY REVIEW
TPHSDY 24,648,2003
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,125,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 153 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (80 mg/m3);
short term exposure limit 20 ppm (150 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (77 mg/m3);
KZG- week 80 ppm (616 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (383 mg/m3), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3787;
Number of Industries 2;
Total Number of Facilities 1,009;
Number of Occupations 7;
Total Number of Employees Exposed 33,152;
Total Number of Female Employees Exposed 27,151


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as an anesthetic
OSHA ANALYTICAL METHOD #103


REFERENCES:

CODEN
REFERENCE
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000 AE Amsterdam. Netherlands) V.16- 1973-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an anesthetic

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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