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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, tert-butyl methyl

RTECS #

KN5250000

CAS #

1634-04-4

Updated

September 201

Molecular Weight

88.17

Molecular Formula

C5H12O

Synonyms

1,1-Dimethylethyl methyl ether
2-Methoxy-2-methylpropane
2-Methyl-2-methoxypropane
2-Methyl-2-methoxypropane fume
Methyl 1,1-dimethylethyl ether
Methyl t-butyl ether
Methyl tert-butyl ether
Methyl tert-butyl ether (ACGIH)
Methyl tertiary butyl ether
Propane, 2-methoxy-2-methyl- (9CI)
tert-Butoxymethane
tert-Butyl methyl ether

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1500 µg/plate (+enzymatic activation step)MUREAV 446,15,1999
specific locus testliver/mouse22.7 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 8000 ppm/6H (multigeneration)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JJATDK 17(S1),S13,1997
inhalation/mouse 4000 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17(S1),S21,1997
inhalation/mouse 8000 ppm/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17(S1),S21,1997
oral/mouse 4.48 mg/kg (28D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male
TOXID9 78,188,2004
oral/mouse 6 gm/kg (5D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductNTIS** OTS0559651

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 141 gm/m3/15MBehavioral: General anestheticANESAV 11,455,1950
inhalation/mouse lethal concentration (50 percent kill): 28000 mg/m3/2HVCVGK* -,268,1994
inhalation/mouse lethal concentration (50 percent kill): 30140 mg/m3/2HBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (4),42,1998
inhalation/mouse lethal concentration (50 percent kill): 30140 mg/m3/2HLung, Thorax, or Respiration: Respiratory obstructionTOVEFN (4),42,1998
inhalation/rat lethal concentration (50 percent kill): 42000 mg/m3/4HBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (4),42,1998
inhalation/rat lethal concentration (50 percent kill): 42000 mg/m3/4HLung, Thorax, or Respiration: Respiratory obstructionTOVEFN (4),42,1998
inhalation/rat lethal concentration (50 percent kill): 41000 mg/m3/4HVCVGK* -,268,1994
inhalation/rat lethal concentration (50 percent kill): 23576 ppm/4HNTIS** PB87-174603
intraperitoneal/mouse lethal dose (50 percent kill): 1700 µL/kgCHHTAT 70,172,1990
intraperitoneal/rat Lethal dose: >148 mg/kgJSGRA2 53,572,1992
intravenous/rat lowest published lethal dose: 148 mg/kgJSGRA2 53,572,1992
ocular/mammal (species unspecified) lowest published toxic dose: 100 pphEye: Conjunctiva irritationTOVEFN (4),42,1998
oral/mouse lethal dose (50 percent kill): 3665 mg/kgTOVEFN (4),42,1998
oral/mouse lethal dose (50 percent kill): 5960 µL/kgCHHTAT 70,172,1990
oral/rat lethal dose (50 percent kill): 4 gm/kgNTIS** PB87-174603
oral/rat lowest published toxic dose: 1000 mg/kgEndocrine: AndrogenicTOSCF2 71,31,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 180 mg/m3/6H/15W- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,268,1994
inhalation/mouse lowest published toxic concentration: 8000 ppm/3D- continuousReproductive: Maternal effects: Uterus, cervix, vaginaTOSCF2 41,77,1998
inhalation/mouse lowest published toxic concentration: 8000 ppm/21D- continuousEndocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
TOSCF2 41,77,1998
inhalation/mouse lowest published toxic concentration: 8000 ppm/16W- continuousEndocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 41,77,1998
inhalation/mouse lowest published toxic concentration: 8000 ppm/32W- continuousReproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Changes in uterine weight
TOSCF2 41,77,1998
inhalation/rat lowest published toxic concentration: 1516 ppm/6H/10D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TXAPA9 143,301,1997
oral/mouse lowest published toxic dose: 4.48 mg/kg/28D- continuousEndocrine: Other changes

Related to Chronic Data: Changes in testicular weight
TOXID9 78,188,2004
oral/rat lowest published toxic dose: 416000 mg/kg/104W- intermittentReproductive: Tumorigenic effects: Testicular tumorsTOXID9 60,432,2001
oral/rat lowest published toxic dose: 3958.5 mg/kg/13W- continuousBehavioral: Fluid intakeTOXID9 -,104,2008
oral/rat lowest published toxic dose: 46774 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,104,2008
oral/rat lowest published toxic dose: 6804 mg/kg/1W- continuousKidney, Ureter, and Bladder: Other changesTOXID9 -,104,2008
oral/rat lowest published toxic dose: 59150 mg/kg/13W- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 -,104,2008
oral/rat lowest published toxic dose: 11200 mg/kg/4W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FCTOD7 46,2402,2008
oral/rat lowest published toxic dose: 22400 mg/kg/4W- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FCTOD7 46,2402,2008
oral/rat lowest published toxic dose: 5600 mg/kg/2W- intermittentEndocrine: Change in LH

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,2402,2008
oral/rat lowest published toxic dose: 11200 mg/kg/2W- intermittentEndocrine: Change in gonadotropins

Endocrine: Androgenic

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,2402,2008
oral/rat lowest published toxic dose: 22400 mg/kg/2W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Endocrine: Change in gonadotropins

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 46,2402,2008
oral/rat lowest published toxic dose: 273750 mg/kg/1Y- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOXID9 -,307,2009
oral/rat lowest published toxic dose: 547500 mg/kg/1Y- continuousKidney, Ureter, and Bladder: Proteinuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,307,2009
oral/rat lowest published toxic dose: 109500 mg/kg/1Y- continuousKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 -,307,2009
oral/rat lowest published toxic dose: 5600 mg/kg/2W- intermittentRelated to Chronic Data: Changes in testicular weightTIHEEC 25,15,2009
oral/rat lowest published toxic dose: 11200 mg/kg/2W- intermittentEndocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Changes in testicular weight
TIHEEC 25,15,2009
oral/rat lowest published toxic dose: 22400 mg/kg/2W- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count
TIHEEC 25,15,2009
oral/rat lowest published toxic dose: 11200 mg/kg/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 25,15,2009
oral/rat lowest published toxic dose: 22400 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIHEEC 25,15,2009
oral/rat lowest published toxic dose: 44800 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Changes in prostate weight
TIHEEC 25,15,2009
oral/rat lowest published toxic dose: 15000 mg/kg/15D- intermittentEndocrine: Evidence of thyroid hyperfunctionTOSCF2 54,168,2000
oral/rat lowest published toxic dose: 22500 mg/kg/15D- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
TOSCF2 54,168,2000
oral/rat lowest published toxic dose: 42000 mg/kg/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration

Related to Chronic Data: Changes in testicular weight
TOSCF2 54,168,2000
oral/rat lowest published toxic dose: 210 mg/kg/14D- continuousBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,82,2003
oral/rat lowest published toxic dose: 4.2 gm/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 17,273,2003
oral/rat lowest published toxic dose: 11200 mg/kg/28D- intermittentLiver: Changes in liver weight

Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 71,31,2003
oral/rat lowest published toxic dose: 7500 mg/kg/11D- intermittentEndocrine: Androgenic

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 71,31,2003
oral/rat lowest published toxic dose: 49 gm/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0540108
oral/rat lowest published toxic dose: 20 gm/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JACTDZ 9(5),525,1990
oral/rat lowest published toxic dose: 27 gm/kg/90D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca
JACTDZ 9(5),525,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 73,339,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,339,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 73,339,1999
TOXICOLOGY REVIEWTOLED5 123,89,2001
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,387,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 659,68,2008
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUREAV 674,101,2009
TOXICOLOGY REVIEWRTOPDW 47,156,2007
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (92 mg/m3), short term exposure limit 75 ppm (275 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (180 mg/m3);KZW 100 ppm (360 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 40 ppm (146 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 40 ppm (144 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm, short term exposure limit 100 ppm, NOV2011
Occupational Exposure Limit-GERMANYMAK 50 ppm (180 mg/m3), 2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (92 mg/m3); short term exposure limit 75 ppm (275 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (180 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 100 mg/m3, short term exposure limit 300 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 30 ppm (110 mg/m3);short term exposure limit 60 ppm (220 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (180 mg/m3), KZG-week 75 ppm (270 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 180 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (92 mg/m3);short term exposure limit 75 ppm (275 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4267; Number of Industries 6; Total Number of Facilities 614; Number of Occupations 9; Total Number of Employees Exposed 5996; Total Number of Female Employees Exposed 1783

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121016/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl tert-butyl ether, 1615
On EPA IRIS database
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