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Ether, tert - butyl methyl

RTECS #: KN5250000

CAS #: 1634-04-4


UPDATE: May 2009 MW: 88.17 MF: C5H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethyl methyl ether
  2. 2 - Methoxy - 2 - methylpropane
  3. 2 - Methyl - 2 - methoxypropane
  4. 2 - Methyl - 2 - methoxypropane fume
  5. Methyl 1,1 - dimethylethyl ether
  6. Methyl t - butyl ether
  1. Methyl tert - butyl ether
  2. Methyl tert - butyl ether (ACGIH)
  3. Methyl tertiary butyl ether
  4. Propane, 2 - methoxy - 2 - methyl - (9CI)
  5. tert - Butoxymethane
  6. tert - Butyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1,500 g/plate (+enzymatic activation step) MUREAV 446,15,1999
specific locus test mouse liver 22.7 mol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 4,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17(S1),S21,1997
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17(S1),S21,1997
inhalation
rat
lowest published toxic concentration: 8,000 ppm/6 hour (multigeneration) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JJATDK 17(S1),S13,1997
oral
mouse
lowest published toxic dose: 6 gm/kg (5 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** OTS0559651
oral
mouse
lowest published toxic dose: 4.48 mg/kg (28 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male
TOXID9 78,188,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 141 gm/m3/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
mouse
lethal concentration (50 percent kill): 28,000 mg/m3/2 hour N/R VCVGK* -,268,1994
inhalation
mouse
lethal concentration (50 percent kill): 30,140 mg/m3/2 hour Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (4),42,1998
inhalation
mouse
lethal concentration (50 percent kill): 30,140 mg/m3/2 hour Lung, Thorax, or Respiration: Respiratory obstruction TOVEFN (4),42,1998
inhalation
rat
lethal concentration (50 percent kill): 23,576 ppm/4 hour N/R NTIS** PB87-174603
inhalation
rat
lethal concentration (50 percent kill): 41,000 mg/m3/4 hour N/R VCVGK* -,268,1994
inhalation
rat
lethal concentration (50 percent kill): 42,000 mg/m3/4 hour Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (4),42,1998
inhalation
rat
lethal concentration (50 percent kill): 42,000 mg/m3/4 hour Lung, Thorax, or Respiration: Respiratory obstruction TOVEFN (4),42,1998
intraperitoneal
mouse
lethal dose (50 percent kill): 1,700 L/kg N/R CHHTAT 70,172,1990
intraperitoneal
rat
lethal dose : >148 mg/kg N/R JSGRA2 53,572,1992
intravenous
rat
lowest published lethal dose: 148 mg/kg N/R JSGRA2 53,572,1992
ocular
mammal (species unspecified)
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TOVEFN (4),42,1998
oral
mouse
lethal dose (50 percent kill): 5,960 L/kg N/R CHHTAT 70,172,1990
oral
mouse
lethal dose (50 percent kill): 3,665 mg/kg N/R TOVEFN (4),42,1998
oral
rat
lethal dose (50 percent kill): 4 gm/kg N/R NTIS** PB87-174603
oral
rat
lowest published toxic dose: 1,000 mg/kg Endocrine: Androgenic TOSCF2 71,31,2003
skin
mammal (species unspecified)
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TOVEFN (4),42,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 180 mg/m3/6 hour/15 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,268,1994
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/3 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 41,77,1998
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/21 day- continuous Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
TOSCF2 41,77,1998
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/16 week- continuous Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 41,77,1998
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/32 week- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Changes in uterine weight
TOSCF2 41,77,1998
inhalation
rat
lowest published toxic concentration: 1,516 ppm/6 hour/10 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 143,301,1997
oral
mouse
lowest published toxic dose: 4.48 mg/kg/28 day- continuous Endocrine: Other changes

Related to Chronic Data: Changes in testicular weight
TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 49 gm/kg/28 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0540108
oral
rat
lowest published toxic dose: 20 gm/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JACTDZ 9(5),525,1990
oral
rat
lowest published toxic dose: 27 gm/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca
JACTDZ 9(5),525,1990
oral
rat
lowest published toxic dose: 15,000 mg/kg/15 day- intermittent Endocrine: Evidence of thyroid hyperfunction TOSCF2 54,168,2000
oral
rat
lowest published toxic dose: 22,500 mg/kg/15 day- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
TOSCF2 54,168,2000
oral
rat
lowest published toxic dose: 42,000 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration

Related to Chronic Data: Changes in testicular weight
TOSCF2 54,168,2000
oral
rat
lowest published toxic dose: 210 mg/kg/14 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,82,2003
oral
rat
lowest published toxic dose: 4.2 gm/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,273,2003
oral
rat
lowest published toxic dose: 11,200 mg/kg/28 day- intermittent Liver: Changes in liver weight

Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 71,31,2003
oral
rat
lowest published toxic dose: 7,500 mg/kg/11 day- intermittent Endocrine: Androgenic

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 71,31,2003
oral
rat
lowest published toxic dose: 416,000 mg/kg/104 week- intermittent Reproductive: Tumorigenic effects: Testicular tumors TOXID9 60,432,2001
oral
rat
lowest published toxic dose: 3,958.5 mg/kg/13 week- continuous Behavioral: Fluid intake TOXID9 -,104,2008
oral
rat
lowest published toxic dose: 46,774 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,104,2008
oral
rat
lowest published toxic dose: 6,804 mg/kg/1 week- continuous Kidney, Ureter, and Bladder: Other changes TOXID9 -,104,2008
oral
rat
lowest published toxic dose: 59,150 mg/kg/13 week- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 -,104,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,339,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,339,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,339,1999
TOXICOLOGY REVIEW
TOLED5 123,89,2001
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,387,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 659,68,2008
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (92 mg/m3), short term exposure limit 75 ppm (275 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 40 ppm (146 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 40 ppm (144 mg/m3), OCT 2002
Occupational Exposure Limit - GERMANY MAK 180 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 180 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (92 mg/m3);
short term exposure limit 75 ppm (275 mg/m3), JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 100 mg/m3, short term exposure limit 300 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 30 ppm (110 mg/m3);
short term exposure limit 60 ppm (220 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (180 mg/m3),KZG- week 75 ppm (270 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (92 mg/m3);
short term exposure limit 75 ppm, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4267;
Number of Industries 6;
Total Number of Facilities 614;
Number of Occupations 9;
Total Number of Employees Exposed 5,996;
Total Number of Female Employees Exposed 1,783


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121016/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an organic solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl tert-butyl ether, 1615


REFERENCES:

CODEN
REFERENCE

ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an organic solvent

Top 50 chemical production: 10.86 billions lbs in 1992, 9.57 billions in 1991

NIOSH PROFILE (METHYL tert-BUTYL ETHER), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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