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Ether, tert - butyl ethyl

RTECS #: KN4730200

CAS #: 637-92-3


UPDATE: February 2009 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethyl ethyl ether
  2. 2 - Ethoxy - 2 - methylpropane
  3. Ethyl 1,1 - dimethylethyl ether
  4. Ethyl tert - butyl oxide
  1. Ethyl tert - butyl ether
  2. Propane, 2 - ethoxy - 2 - methyl - (9CI)
  3. tert - Butyl ethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 ÁL/24 hour moderate NTIS** OTS0557630
skin
rabbit
500 ÁL/4 hour moderate NTIS** OTS0557630


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 123 gm/m3/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
rat
lethal concentration (50 percent kill): >5,880 mg/m3/4 hour N/R NTIS** OTS0557661
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour Olfaction: Other olfaction effects

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 72,319,2003
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,148,2004
oral
rat
lethal dose : >5 gm/kg N/R NTIS** OTS0557630
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg Olfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
NTIS** OTS0557630


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5,000 ppm/6 hour/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight
TOXID9 36(1 Pt2),340,1997
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight
TOXID9 36(1 Pt2),340,1997
inhalation
rat
lowest published toxic concentration: 4,000 ppm/6 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Liver: Changes in liver weight
NTIS** OTS0557660
oral
rat
lowest published toxic dose: 25.2 gm/kg/14 day- intermittent Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,132,2003
skin
rat
lowest published toxic dose: 7 mL/kg/28 day- intermittent Blood: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0557613


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 123,89,2001
TOXICOLOGY REVIEW
ENTOX* -,387,2005
TOXICOLOGY REVIEW
CRTXB2 37,287,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m3), MAR2002
Occupational Exposure Limit - RUSSIA short term exposure limit 300 mg/m3, time-weighted average 100 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Primary Irritant

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