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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, tert-butyl ethyl

RTECS #

KN4730200

CAS #

637-92-3

Updated

September 201

Molecular Weight

102.20

Molecular Formula

C6H14O

Synonyms

1,1-Dimethylethyl ethyl ether
2-Ethoxy-2-methylpropane
Ethyl 1,1-dimethylethyl ether
Ethyl tert-butyl ether
Ethyl tert-butyl oxide
Propane, 2-ethoxy-2-methyl- (9CI)
tert-Butyl ethyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H moderateNTIS** OTS0557630
skin /rabbit 500 µL/4H moderateNTIS** OTS0557630

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 16800 mg/kg (14D male)Reproductive: Other effects on maleTOLED5 190,74,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 123 gm/m3/15MBehavioral: General anestheticANESAV 11,455,1950
inhalation/mouse lethal concentration (50 percent kill): 24950 mg/m3/2HBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
inhalation/rat lowest published toxic concentration: 1650 mg/m3Behavioral: Alteration of classical conditioningTOVEFN (3),29,2007
inhalation/rat lethal concentration (50 percent kill): 36200 mg/m3/4HBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
inhalation/rat lethal concentration (50 percent kill): >5880 mg/m3/4HNTIS** OTS0557661
inhalation/rat lowest published toxic concentration: 250 ppm/6HOlfaction: Other olfaction effects

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 72,319,2003
inhalation/rat lowest published toxic concentration: 250 ppm/6HLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,148,2004
intraperitoneal/guinea pig lethal dose (50 percent kill): 3400 mg/kgBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
intraperitoneal/rat lethal dose (50 percent kill): 2320 mg/kgBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
oral/mouse lethal dose (50 percent kill): 6710 mg/kgBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
oral/rat lethal dose (50 percent kill): 7150 mg/kgBehavioral: Somnolence (general depressed activity)TOVEFN (3),29,2007
oral/rat Lethal dose: >5 gm/kgNTIS** OTS0557630
skin/rabbit lethal dose (50 percent kill): >2 gm/kgOlfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
NTIS** OTS0557630

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 5000 ppm/6H/13W- intermittentLiver: Other changes

Liver: Changes in liver weight
TOXID9 36(1 Pt2),340,1997
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight
TOXID9 36(1 Pt2),340,1997
inhalation/rat lowest published toxic concentration: 4000 ppm/6H/4W- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Liver: Changes in liver weight
NTIS** OTS0557660
oral/rat lowest published toxic dose: 25.2 gm/kg/14D- intermittentEndocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,132,2003
oral/rat lowest published toxic dose: 20000 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOVEFN (3),29,2007
oral/rat lowest published toxic dose: 25000 mg/kg/5W- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (3),29,2007
oral/rat lowest published toxic dose: 16800 mg/kg/14D- intermittentEndocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 190,74,2009
skin/rat lowest published toxic dose: 7 mL/kg/28D- intermittentBlood: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0557613

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 123,89,2001
TOXICOLOGY REVIEWENTOX* -,387,2005
TOXICOLOGY REVIEWCRTXB2 37,287,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (21 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (21 mg/m3); short term exposure limit ppm ( mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 300 mg/m3, time-weighted average 100 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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