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Ether, bis (pentabromophenyl)

RTECS #: KN3525000

CAS #: 1163-19-5


UPDATE: August 2008 MW: 959.22 MF: C12Br10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,1' - Oxybis (2,3,4,5,6 - pentabromobenzene)
  2. BR 55N
  3. Benzene, 1,1' - oxybis (2,3,4,5,6 - pentabromo - (9CI)
  4. Berkflam B 10E
  5. Bis (pentabromophenyl) ether
  6. Bromkal 82 - ode
  7. Bromkal 83 - 10DE
  8. DBDPO
  9. DE - 83R
  10. Dbdpo
  11. De 83R
  12. Decabrom
  13. Decabrominated diphenyl ether
  14. Decabromobiphenyl ether
  1. Decabromobiphenyl oxide
  2. Decabromodiphenyl ether
  3. Decabromodiphenyl oxide
  4. Decabromophenyl ether
  5. Ether, decabromodiphenyl
  6. FR 300
  7. FR 300BA
  8. FRP 53
  9. NCI - C55287
  10. PBDE 209
  11. Pentabromophenyl ether
  12. Saytex 102
  13. Saytex 102E
  14. Tardex 100


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 ÁL severe NTIS** OTS0522261


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test human mammary gland 0.1 nmol/L/24 hour MUTAEX 21,351,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) COTODO 1,52,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,163,000 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTIS** PB86-247780/AS
oral
rat
lowest published toxic dose: 1,092 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-309,1986
oral
rat
lowest published toxic dose: 1,081,500 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB86-247780/AS
oral
rat
lowest published toxic dose: 1,802,500 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB86-247780/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rabbit
lethal concentration (50 percent kill): 48.2 gm/m3/1 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral
mouse
lowest published toxic dose: 20.1 mg/kg Brain and Coverings: Other degenerative changes NRTXDN 29,152,2008
oral
rat
lowest published lethal dose: 500 mg/kg N/R NTIS** OTS0522261
oral
rat
lethal dose (50 percent kill): 2 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral
rat
lowest published toxic dose: 6.7 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NRTXDN 28,136,2007
skin
rat
lethal dose : >3 gm/kg N/R GISAAA 48(8),18,1983
skin
rabbit
lethal dose (50 percent kill): 2 gm/kg/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
unreported route
mouse
lowest published toxic dose: 20.1 mg/kg Behavioral: Alteration of classical conditioning TOXID9 60,217,2001
unreported route
mouse
lowest published toxic dose: 20.1 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOXID9 90,297,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 25,000 mg/kg/50 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 224,33,2006
oral
mouse
lowest published toxic dose: 280 mg/kg/14 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Endocrine: Other changes
NETEEC 29,511,2007
oral
mouse
lowest published toxic dose: 280 mg/kg/14 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NETEEC 29,511,2007
oral
mouse
lowest published toxic dose: 280 mg/kg/14 day- intermittent Behavioral: Alteration of operant conditioning NETEEC 29,590,2007
oral
rat
lowest published toxic dose: 24 gm/kg/30 day- continuous Liver: Other changes

Endocrine: Thyroid weight (goiter)
EVHPAZ 11,153,1975
oral
rat
lowest published toxic dose: 4 mg/kg/4 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOSCF2 61,76,2001
oral
rat
lowest published toxic dose: 24,000 mg/kg/30 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in thyroid weight
VCVGK* -,316,1994
oral
rat
lowest published toxic dose: 2,400 mg/kg/30 day- continuous Liver: Changes in liver weight

Endocrine: Toxic goiter- hypofunction
EVHPAZ 109,49,2001
unreported route
rat
lowest published toxic dose: 1,344 mg/kg/2 week- intermittent Liver: Changes in liver weight VCVGK* -,316,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 48,73,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1365,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1365,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1365,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,507,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4046;
Number of Industries 12;
Total Number of Facilities 981;
Number of Occupations 30;
Total Number of Employees Exposed 32,661;
Total Number of Female Employees Exposed 8,875


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as brominated lame retardants and a fire-retardent for thermoplastics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-309,1986
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

COTODO Journal of Fire and Flammability/Combustion Toxicology Supplement. (Westport, CT) V.1-2, 1974-75. For publisher information, see JCTODH.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as brominated lame retardants and a fire-retardent for thermoplastics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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