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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(pentabromophenyl)

RTECS #

KN3525000

CAS #

1163-19-5

Updated

July 2013

Molecular Weight

959.22

Molecular Formula

C12Br10O

Synonyms

1,1'-Oxybis(2,3,4,5,6-pentabromobenzene)
Benzene, 1,1'-oxybis(2,3,4,5,6-pentabromo- (9CI)
Berkflam B 10E
Bis(pentabromophenyl)ether
BR 55N
Bromkal 82-ode
Bromkal 83-10DE
DBDPO
Dbdpo
De 83R
DE-83R
Decabrom
Decabrominated diphenyl ether
Decabromobiphenyl ether
Decabromobiphenyl oxide
Decabromodiphenyl ether
Decabromodiphenyl oxide
Decabromophenyl ether
Ether, decabromodiphenyl
FR 300
FR 300BA
FRP 53
NCI-C55287
PBDE 209
Pentabromophenyl ether
Saytex 102
Saytex 102E
Tardex 100

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL severeNTIS** OTS0522261

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagemultiple/non-mammalian species0.1 µg/L/48HEMMUEG 48,735,2007
micronucleus testmammary gland/human0.1 nmol/L/24HMUTAEX 21,351,2006
micronucleus testother cell types/human0.001 nmol/L/24HMUTAEX 21,351,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)COTODO 1,52,1974
oral/mouse 39600 mg/kg (10-21D preg/21D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTOLED5 180S,S205,2008
oral/mouse 8.46 gm/kg (10D preg-21D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
ETOPFR 26,315,2008
oral/mouse 1.107 gm/kg (10D preg-21D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemETOPFR 26,315,2008

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2163000 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTIS** PB86-247780/AS
oral/rat lowest published toxic dose: 1092 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-309,1986
oral/rat lowest published toxic dose: 1081500 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB86-247780/AS
oral/rat lowest published toxic dose: 1802500 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB86-247780/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lethal concentration (50 percent kill): 48.2 gm/m3/1HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral/mouse lowest published toxic dose: 20.1 mg/kgBrain and Coverings: Other degenerative changesNRTXDN 29,152,2008
oral/rat lowest published toxic dose: 6.7 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NRTXDN 28,136,2007
oral/rat lowest published lethal dose: 500 mg/kgNTIS** OTS0522261
oral/rat lethal dose (50 percent kill): 2 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
skin/rabbit lethal dose (50 percent kill): 2 gm/kg/24HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
skin/rat Lethal dose: >3 gm/kgGISAAA 48(8),18,1983
unreported route/mouse lowest published toxic dose: 20.1 mg/kgBehavioral: Alteration of classical conditioningTOXID9 60,217,2001
unreported route/mouse lowest published toxic dose: 20.1 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 90,297,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 25000 mg/kg/50D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 224,33,2006
oral/mouse lowest published toxic dose: 280 mg/kg/14D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Endocrine: Other changes
NETEEC 29,511,2007
oral/mouse lowest published toxic dose: 280 mg/kg/14D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NETEEC 29,511,2007
oral/mouse lowest published toxic dose: 280 mg/kg/14D- intermittentBehavioral: Alteration of operant conditioningNETEEC 29,590,2007
oral/mouse lowest published toxic dose: 300 mg/kg/15D- intermittentBehavioral: Antianxiety

Behavioral: Alteration of classical conditioning
FCTOD7 50,707,2012
oral/rat lowest published toxic dose: 24 gm/kg/30D- continuousLiver: Other changes

Endocrine: Thyroid weight (goiter)
EVHPAZ 11,153,1975
oral/rat lowest published toxic dose: 4 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOSCF2 61,76,2001
oral/rat lowest published toxic dose: 24000 mg/kg/30D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in thyroid weight
VCVGK* -,316,1994
oral/rat lowest published toxic dose: 2400 mg/kg/30D- continuousLiver: Changes in liver weight

Endocrine: Toxic goiter- hypofunction
EVHPAZ 109,49,2001
oral/rat lowest published toxic dose: 112 mg/kg/28D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductTOLED5 179,6,2008
oral/rat lowest published toxic dose: 5.6 mg/kg/28D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsTOLED5 179,6,2008
oral/rat lowest published toxic dose: 14 mg/kg/28D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOLED5 179,6,2008
oral/rat lowest published toxic dose: 840 mg/kg/28D- intermittentLiver: Other changesTOLED5 179,6,2008
oral/rat lowest published toxic dose: 1176 mg/kg/28D- intermittentEndocrine: Changes in thymus weightTOLED5 179,6,2008
oral/rat lowest published toxic dose: 5.04 mg/kg/28D- intermittentEndocrine: Other changesTOLED5 179,6,2008
oral/rat lowest published toxic dose: 33.6 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other
TOLED5 179,6,2008
oral/rat lowest published toxic dose: 16.8 mg/kg/28D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesTOLED5 179,6,2008
unreported route/rat lowest published toxic dose: 1344 mg/kg/2W- intermittentLiver: Changes in liver weightVCVGK* -,316,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 48,73,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1365,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1365,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1365,1999
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,507,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWNRTXDN 32,9,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4046; Number of Industries 12; Total Number of Facilities 981; Number of Occupations 30; Total Number of Employees Exposed 32661; Total Number of Female Employees Exposed 8875

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse,rat
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-309,1986
On EPA IRIS database
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