Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(2-methoxyethyl)

RTECS #

KN3339000

CAS #

111-96-6

Updated

July 2013

Molecular Weight

134.20

Molecular Formula

C6H14O3

Synonyms

1,1'-Oxybis(2-methoxyethane)
2,5,8-Trioxanonane
Bis(2-methoxyethyl)ether
DEGDME
Diethyl glycol dimethyl ether
Diethylene glycol dimethyl ether
Diglyme
Ethane, 1,1'-oxybis(2-methoxy- (9CI)
Glyme 2
Methyldiglyme
Poly-Solv

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testinhalation/rat1000 ppm/5D-continuousNTIS** PB83-138198
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster250 ppm/165MNTIS** PB83-138198
sperm morphologyinhalation/mouse1000 ppm/5D-continuousNTIS** PB83-138198

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1100 ppm/6H (2W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 59,239,1989
inhalation/rat 1000 ppm (5D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)HPV205 -,-,2003
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV205 -,-,2003
oral/rat 500 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Maternal- fetal exchangeFAATDF 16(3),567,1991
oral/rat 13680 mg/kg (20D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TIHEEC 5,1099,1989
oral/mouse 537 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 35,321,1987
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** PB86-135233
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)NTIS** PB86-135233
oral/mouse 5 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB86-135233
oral/rabbit 1400 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 19,238,1992
oral/mouse 24000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)EVHPAZ 57,141,1984
oral/rabbit 700 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
NTIS** #PB87-209532
oral/rabbit 1400 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
NTIS** #PB87-209532
oral/rabbit 1400 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB87-209532
oral/mouse 625 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB86-135233
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB86-135233
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB86-135233
oral/mouse 5000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** #PB86-135233
oral/hamster 7200 mg/kg (5-13D pregnant)Reproductive: Other developmental abnormalitiesNTIS** #PB88-131040

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 741.6 mg/m3/4HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOVEFN (1),29,1996
inhalation/rat lethal concentration (50 percent kill): >11000 mg/m3/7HLung, Thorax, or Respiration: DyspneaHPV205 -,-,2003
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTOVEFN (1),29,1996
oral/mouse lethal dose (50 percent kill): 6 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral/mouse lethal dose (50 percent kill): 6000 mg/kgTOVEFN (1),29,1996
oral/mouse lethal dose (16 percent kill): 5300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),29,1996
oral/mouse lowest published lethal dose: 7100 mg/kgTOVEFN (1),29,1996
oral/rat lowest published lethal dose: 6200 mg/kgTOVEFN (1),29,1996
oral/rat lethal dose (50 percent kill): 5400 mg/kgTOVEFN (1),29,1996
oral/rat lethal dose (16 percent kill): 4800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),29,1996
oral/rat lethal dose (50 percent kill): 5400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral/rat lowest published lethal dose: 7500 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV205 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 110 ppm/2W- intermittentEndocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
HPV205 -,-,2003
oral/mouse lowest published toxic dose: 2500 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB86-135233
oral/mouse lowest published toxic dose: 24000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/rabbit lowest published toxic dose: 2450 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB87-209532
oral/rabbit lowest published toxic dose: 700 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB87-209532

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 30,307,2000
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 726,91,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (27 mg/m3);KZW 20 ppm (108 mg/m3), skin, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (27 mg/m3), skin, MAY2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (28 mg/m3), 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (27 mg/m3), KZG-week 40 ppm (216 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 27 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T0698; Number of Industries 2; Total Number of Facilities 13; Number of Occupations 2; Total Number of Employees Exposed 207; Total Number of Female Employees Exposed 52
National Occupational Hazard Survey 1974Hazard Code T0698; Number of Industries 1; Total Number of Facilities 27; Number of Occupations 3; Total Number of Employees Exposed 191

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0693-9068
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP