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Ether, bis (2 - methoxyethyl)

RTECS #: KN3339000

CAS #: 111-96-6


UPDATE: August 2008 MW: 134.20 MF: C6H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1' - Oxybis (2 - methoxyethane)
  2. 2,5,8 - Trioxanonane
  3. Bis (2 - methoxyethyl) ether
  4. DEGDME
  5. Diethyl glycol dimethyl ether
  6. Diethylene glycol dimethyl ether
  1. Diglyme
  2. Ethane, 1,1' - oxybis (2 - methoxy - (9CI)
  3. Glyme 2
  4. Methyldiglyme
  5. Poly - Solv


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
dominant lethal test inhalation
rat
1,000 ppm/5 day- continuous NTIS** PB83-138198
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
250 ppm/165 minute NTIS** PB83-138198
sperm morphology inhalation
mouse
1,000 ppm/5 day- continuous NTIS** PB83-138198


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,100 ppm/6 hour (2 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 59,239,1989
oral
hamster
lowest published toxic dose: 7,200 mg/kg (5-13 day pregnant) Reproductive: Other developmental abnormalities NTIS** #PB88-131040
oral
mouse
lowest published toxic dose: 537 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 35,321,1987
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** PB86-135233
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS** PB86-135233
oral
mouse
lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB86-135233
oral
mouse
lowest published toxic dose: 24,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 625 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB86-135233
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB86-135233
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB86-135233
oral
mouse
lowest published toxic dose: 5,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB86-135233
oral
rat
lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Maternal- fetal exchange FAATDF 16(3),567,1991
oral
rat
lowest published toxic dose: 13,680 mg/kg (20 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TIHEEC 5,1099,1989
oral
rabbit
lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 19,238,1992
oral
rabbit
lowest published toxic dose: 700 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
NTIS** #PB87-209532
oral
rabbit
lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
NTIS** #PB87-209532
oral
rabbit
lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB87-209532


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 741.6 mg/m3/4 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOVEFN (1),29,1996
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TOVEFN (1),29,1996
oral
mouse
lethal dose (50 percent kill): 6 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral
mouse
lethal dose (50 percent kill): 6,000 mg/kg N/R TOVEFN (1),29,1996
oral
mouse
lethal dose (16 percent kill): 5,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),29,1996
oral
mouse
lethal dose : 7,100 mg/kg N/R TOVEFN (1),29,1996
oral
rat
lethal dose (50 percent kill): 5,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral
rat
lethal dose (50 percent kill): 5,400 mg/kg N/R TOVEFN (1),29,1996
oral
rat
lethal dose (16 percent kill): 4,800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),29,1996
oral
rat
lethal dose : 6,200 mg/kg N/R TOVEFN (1),29,1996
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TOVEFN (1),29,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 24,000 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB86-135233
oral
rabbit
lowest published toxic dose: 2,450 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB87-209532
oral
rabbit
lowest published toxic dose: 700 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB87-209532


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CRTXB2 30,307,2000
TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (27 mg/m3), OCT 2002
Occupational Exposure Limit - GERMANY MAK 28 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 27 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (27 mg/m3),KZG- week 40 ppm (216 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0698;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 3;
Total Number of Employees Exposed 191
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0698;
Number of Industries 2;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 207;
Total Number of Female Employees Exposed 52


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0693-9068
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an industrial solvent

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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