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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(2-ethoxyethyl)

RTECS #

KN3160000

CAS #

112-36-7

Updated

August 2008

Molecular Weight

162.26

Molecular Formula

C8H18O3

Synonyms

1-Ethoxy-2-(beta-ethoxyethoxy)ethane
3,6,9-Trioxaundecane
Bis(2-ethoxyethyl) ether
Diethyl carbitol
Diethylene glycol diethyl ether
Diethylether diethylenglykolu (Czech)
Ethyl diglyme

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg moderateUCDS** 4/25/1958

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 24 gm/kg (7-14D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
EVHPAZ 57,141,1984
oral/mouse 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** PB88-168257
oral/mouse 24000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects
EVHPAZ 57,141,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 1850 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/rat lethal dose (50 percent kill): 4970 mg/kgUCDS** 4/25/1958
skin/rabbit lethal dose (50 percent kill): 6700 µL/kgUCDS** 4/25/1958

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1200 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** #PB88-168257
oral/mouse lowest published toxic dose: 15000 mg/kg/10D- intermittentBehavioral: Sleep

Behavioral: Ataxia

Behavioral: Coma
NTIS** #PB88-168257
oral/rabbit lowest published toxic dose: 4000 mg/kg/14D- intermittentBehavioral: Ataxia

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
NTIS** #PB88-168497
oral/rabbit lowest published toxic dose: 4000 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB88-168497

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 25,192,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84038; Number of Industries 3; Total Number of Facilities 172; Number of Occupations 5; Total Number of Employees Exposed 3489; Total Number of Female Employees Exposed 2128
National Occupational Hazard Survey 1974Hazard Code 84038; Number of Industries 7; Total Number of Facilities 1327; Number of Occupations 8; Total Number of Employees Exposed 3060

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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