Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(2-chloro-1-methylethyl)

RTECS #

KN1750000

CAS #

108-60-1; 52438-91-2

Updated

November 2007

Molecular Weight

171.08

Molecular Formula

C6H12Cl2O

Synonyms

(2-Chloro-1-methylethyl) ether
2-(1-Methyl-2-chloroethoxy)-1-chloropropane
2-(1-Methyl-2-chloroethoxy)-1-chloropropane, fume
2,2'-Dichloroisopropyl ether
2,2'-Oxybis(1-chloropropane)
beta,beta'-Dichlorodiisopropyl ether
Bis(1-chloro-2-propyl) ether
Bis(2-chloro-1-methylethyl) ether
Bis(2-chloroisopropyl) ether
Bis(beta-chloroisopropyl)ether
DCIP
DCIP (nematocide)
Dichlorodiisopropyl ether
Dichloroisopropyl ether
Isopropylchlorex
NCI-C50044
Nemamol
Nemamort
Nemamorte
Propane, 2,2'-oxybis(1-chloro-
RCRA waste number U027

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster124 mg/LEMMUEG 10(Suppl 10),1,1987
mutation in mammalian somatic cellslymphocyte/mouse250 mg/LEMMUEG 12,85,1988
mutation in microorganisms/Salmonella typhimurium1000 mg/L/2H (+/-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium1 gm/plate (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
sister chromatid exchangeovary/hamster11300 µg/LEMMUEG 10(Suppl 10),1,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 103000 mg/kg/180D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB83-169615
oral/mouse lowest published toxic dose: 103000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-169615

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 700 ppm/5HEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
BJIMAG 27,1,1970
inhalation/rat Lowest published lethal concentration: 5700 mg/m3/1HEye: Conjunctiva irritation

Behavioral: Ataxia
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 700 mg/m3/5HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 400 mg/m3/6HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 240 mg/m3/8HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
oral/mouse lethal dose (50 percent kill): 1400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal
VCVGK* -,284,1994
oral/mouse lethal dose (50 percent kill): 296 mg/kgYKYUA6 37,597,1986
oral/rat lethal dose (50 percent kill): 1300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal
VCVGK* -,284,1994
oral/rat lethal dose (50 percent kill): 240 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 3 mL/kgAMIHBC 4,119,1951
skin/rat lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,83,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4424 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-239,1982
oral/mouse lowest published toxic dose: 876 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 2,295,1977
oral/mouse lowest published toxic dose: 873600 mg/kg/104W- continuousBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,285,1994
oral/rat lowest published toxic dose: 11250 mg/kg/45D- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GISAAA 50(5),69,1985
oral/rat lowest published toxic dose: 2340 mg/kg/26W- intermittentBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 50(5),69,1985
oral/rat lowest published toxic dose: 364 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 2,296,1977
oral/rat lowest published toxic dose: 11250 mg/kg/45D- intermittentBrain and Coverings: Changes in brain weight

Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 2250 mg/kg/45D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 660 mg/kg/152D- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 228 mg/kg/152D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,285,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,149,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,149,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1275,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);no evidence:ratNCITR* NCI-TR-191,1979
TOP