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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-phenoxy-

RTECS #

KM0350000

CAS #

122-99-6

Updated

July 2013

Molecular Weight

138.18

Molecular Formula

C8H10O2

Synonyms

1-Hydroxy-2-phenoxyethane
2-Fenoxyethanol (Czech)
2-Phenoxyethanol
Arosol
beta-Hydroxyethyl phenyl ether
Dowanol EP
Dowanol EPH
Emeressence 1160
Emery 6705
Ethylene glycol monophenyl ether
Ethylene glycol phenyl ether
Fenyl-cellosolve (Czech)
Fenylcelosolv (Czech)
Glycol monophenyl ether
Phenoxethol
Phenoxetol
Phenoxyethanol
Phenoxyethyl alcohol
Phenoxytol
Phenyl cellosolve
Phenylmonoglycol ether
Rose ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 6 mg moderateUCDS** 6/24/1958
eye /rabbit 250 µg/24H severe85JCAE -,637,1986
skin /rabbit 500 mg/24H mild85JCAE -,637,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibition/Escherichia coli2000 ppmMCBIA7 28,7,1980
other mutation test systems/Escherichia coli2000 ppmMCBIA7 28,7,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 911.4 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.035 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intraperitoneal/mouse lethal dose (50 percent kill): 490 mg/kgBrain and Coverings: Other degenerative changesTOVEFN (3),37,1996
intraperitoneal/rat lethal dose (50 percent kill): 554 mg/kgBrain and Coverings: Other degenerative changesTOVEFN (3),37,1996
oral/mouse lethal dose (50 percent kill): 933 mg/kgBrain and Coverings: Other degenerative changesTOVEFN (3),37,1996
oral/rat lethal dose (50 percent kill): 1260 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
skin/rabbit lethal dose (50 percent kill): 5 mL/kgUCDS** 6/24/1958
skin/rat lethal dose (50 percent kill): 14422 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaJACTDZ 9,259,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 15 mg/m3/9W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired
TOVEFN (3),37,1996
oral/rabbit lowest published toxic dose: 3 gm/kg/10D- intermittentBehavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0531470
oral/rat lowest published toxic dose: 182 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),259,1990
oral/rat lowest published toxic dose: 17500 mg/kg/14D- intermittentGastrointestinal: Alteration in gastric secretion

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0531470
skin/rabbit lowest published toxic dose: 14 gm/kg/14D- intermittentBlood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),259,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFAATDF 13,747,1989

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (110 mg/m3);KZW 20 ppm (110 mg/m3), skin, 2007
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (110 mg/m3), short term exposure limit 50 ppm (290 mg/m3), skin, NOV2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (110 mg/m3), skin, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (110 mg/m3), KZG-week 40 ppm (220 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 110 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83449; Number of Industries 63; Total Number of Facilities 5523; Number of Occupations 77; Total Number of Employees Exposed 111040; Total Number of Female Employees Exposed 46637
National Occupational Hazard Survey 1974Hazard Code 83449; Number of Industries 18; Total Number of Facilities 711; Number of Occupations 19; Total Number of Employees Exposed 9560

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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