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Ethanol, 2 - phenoxy -

RTECS #: KM0350000

CAS #: 122-99-6


UPDATE: February 2008 MW: 138.18 MF: C8H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 2 - phenoxyethane
  2. 2 - Fenoxyethanol (Czech)
  3. 2 - Phenoxyethanol
  4. Arosol
  5. Dowanol EP
  6. Dowanol EPH
  7. Emeressence 1160
  8. Emery 6705
  9. Ethylene glycol monophenyl ether
  10. Ethylene glycol phenyl ether
  11. Fenyl - cellosolve (Czech)
  1. Fenylcelosolv (Czech)
  2. Glycol monophenyl ether
  3. Phenoxethol
  4. Phenoxetol
  5. Phenoxyethanol
  6. Phenoxyethyl alcohol
  7. Phenoxytol
  8. Phenyl cellosolve
  9. Phenylmonoglycol ether
  10. Rose ether
  11. beta - Hydroxyethyl phenyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
6 mg moderate UCDS** 6/24/1958
eye
rabbit
250 g/24 hour severe 85JCAE -,637,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,637,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition Escherichia coli 2,000 ppm MCBIA7 28,7,1980
other mutation test systems Escherichia coli 2,000 ppm MCBIA7 28,7,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 490 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
intraperitoneal
rat
lethal dose (50 percent kill): 554 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
oral
mouse
lethal dose (50 percent kill): 933 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
oral
rat
lethal dose (50 percent kill): 1,260 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
skin
rat
lethal dose (50 percent kill): 14,422 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema JACTDZ 9,259,1990
skin
rabbit
lethal dose (50 percent kill): 5 mL/kg N/R UCDS** 6/24/1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 15 mg/m3/9 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired
TOVEFN (3),37,1996
oral
rat
lowest published toxic dose: 182 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),259,1990
oral
rat
lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Gastrointestinal: Alteration in gastric secretion

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0531470
oral
rabbit
lowest published toxic dose: 3 gm/kg/10 day- intermittent Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0531470
skin
rabbit
lowest published toxic dose: 14 gm/kg/14 day- intermittent Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),259,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FAATDF 13,747,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 110 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 110 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (110 mg/m3),KZG- week 40 ppm (220 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83449;
Number of Industries 18;
Total Number of Facilities 711;
Number of Occupations 19;
Total Number of Employees Exposed 9,560
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83449;
Number of Industries 63;
Total Number of Facilities 5,523;
Number of Occupations 77;
Total Number of Employees Exposed 111,040;
Total Number of Female Employees Exposed 46,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for NITROCELLULOSE, and ester type resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as solvent for NITROCELLULOSE, and ester type resins

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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