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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2,2'-thiodi-

RTECS #

KM2975000

CAS #

111-48-8

Updated

November 2007

Molecular Weight

122.20

Molecular Formula

C4H10O2S

Synonyms

2,2'-Thiodiethanol
beta,beta'-Dihydroxydiethyl sulfide
beta,beta'-Dihydroxyethyl sulfide
beta-Hydroxyethyl sulfide
beta-Thiodiglycol
Bis(2-hydroxyethyl)sulfide
Bis(beta-hydroxyethyl)sulfide
Glyecine A
Kromfax solvent
Sulfide, bis(2-hydroxyethyl)
Thiodiethylene glycol
Thiodiglycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg moderateAJOPAA 29,1363,1946
skin /rabbit 500 mg open irritation test mildUCDS** 11/3/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster5 gm/L (-enzymatic activation step)TOXID9 78,31,2004
Cytogenetic Analysisovary/hamster4 gm/L (+enzymatic activation step)TOXID9 78,31,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 58.05 gm/kg (5-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 72(Suppl 1),341,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/rabbit lethal dose (50 percent kill): 3 gm/kgJPETAB 93,1,1948
oral/guinea pig lethal dose (50 percent kill): 3960 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/rat lethal dose (50 percent kill): 6610 mg/kgJIHTAB 23,259,1941
skin/rabbit lethal dose (50 percent kill): 20 mL/kgUCDS** 11/3/1971
subcutaneous/mouse lethal dose (50 percent kill): 4 gm/kgGastrointestinal: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Other changes
JPETAB 93,1,1948
subcutaneous/rat lethal dose (50 percent kill): 4 gm/kgJPETAB 93,1,1948

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 58.05 gm/kg/15D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,341,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWIJTOFN 24,435,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 82023; Number of Industries 6; Total Number of Facilities 167; Number of Occupations 13; Total Number of Employees Exposed 5259

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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