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Ethanol, 2,2' - thiodi -

RTECS #: KM2975000

CAS #: 111-48-8


UPDATE: November 2007 MW: 122.20 MF: C4H10O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,2' - Thiodiethanol
  2. Bis (2 - hydroxyethyl) sulfide
  3. Bis (beta - hydroxyethyl) sulfide
  4. Glyecine A
  5. Kromfax solvent
  6. Sulfide, bis (2 - hydroxyethyl)
  1. Thiodiethylene glycol
  2. Thiodiglycol
  3. beta,beta' - Dihydroxyethyl sulfide
  4. beta,beta' - Dihydroxydiethyl sulfide
  5. beta - Hydroxyethyl sulfide
  6. beta - Thiodiglycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg moderate AJOPAA 29,1363,1946
skin
rabbit
500 mg open irritation test mild UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 5 gm/L (-enzymatic activation step) TOXID9 78,31,2004
cytogenetic analysis hamster ovary 4 gm/L (+enzymatic activation step) TOXID9 78,31,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 58.05 gm/kg (5-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),341,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lethal dose (50 percent kill): 3 gm/kg N/R JPETAB 93,1,1948
oral
guinea pig
lethal dose (50 percent kill): 3,960 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
rat
lethal dose (50 percent kill): 6,610 mg/kg N/R JIHTAB 23,259,1941
subcutaneous
mouse
lethal dose (50 percent kill): 4 gm/kg Gastrointestinal: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Other changes
JPETAB 93,1,1948
subcutaneous
rat
lethal dose (50 percent kill): 4 gm/kg N/R JPETAB 93,1,1948
skin
rabbit
lethal dose (50 percent kill): 20 mL/kg N/R UCDS** 11/3/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 58.05 gm/kg/15 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,341,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
IJTOFN 24,435,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82023;
Number of Industries 6;
Total Number of Facilities 167;
Number of Occupations 13;
Total Number of Employees Exposed 5,259


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as hygroscopic agent in textile printing, solvent for basic colors

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

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