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Ethanol, 2 - propoxy -

RTECS #: KM2800000

CAS #: 2807-30-9


UPDATE: May 2008 MW: 104.17 MF: C5H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Propoxyethanol
  2. Ektasolve EP
  3. Ethylene glycol mono - n - propyl ether
  1. Ethylene glycol mono propyl ether
  2. Monopropyl ether of ethylene glycol
  3. Propyl cellosolve


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe EVHPAZ 57,165,1984
eye
rabbit
750 g/24 hour severe 85JCAE -,628,1986
skin
guinea pig
500 mg mild EVHPAZ 57,165,1984
skin
rabbit
500 mg/24 hour mild 85JCAE -,628,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 32,93,1985
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0571682
oral
mouse
lowest published toxic dose: 16 gm/kg (7-14 day pregnant) Reproductive: Effects on newborn: Stillbirth NTIS** PB86-197605


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,530 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation
rat
lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat
lethal concentration (50 percent kill): 9,060 mg/m3 N/R VCVGK* -,164,1984
oral
mouse
lethal dose (50 percent kill): 1,774 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0570960
oral
rat
lethal dose (50 percent kill): 3,089 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 57,165,1984
oral
rat
lethal dose (50 percent kill): 3,090 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition
VCVGK* -,164,1984
skin
guinea pig
lethal dose (50 percent kill): 1 gm/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 57,165,1984
skin
rabbit
lethal dose (50 percent kill): 960 L/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,164,1994
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
EVHPAZ 57,165,1984
inhalation
rat
lowest published toxic concentration: 425 mg/m3/6 hour/10 day- intermittent Blood: Changes in erythrocyte (RBC) count VCVGK* -,164,1994
inhalation
rabbit
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,164,1994
oral
rat
lowest published toxic dose: 11,700 mg/kg/6 week- intermittent Kidney, Ureter, and Bladder: Hematuria

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
EVHPAZ 57,165,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,451,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (110 mg/m3), OCT 2002
Occupational Exposure Limit - GERMANY MAK 86 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 44 mg/m3, Skin, 2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (45 mg/m3);
short term exposure limit 20 ppm (90 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (85 mg/m3),KZG- week 40 ppm (170 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3118;
Number of Industries 73;
Total Number of Facilities 11,635;
Number of Occupations 26;
Total Number of Employees Exposed 73,812
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3118;
Number of Industries 80;
Total Number of Facilities 10,270;
Number of Occupations 68;
Total Number of Employees Exposed 99,040;
Total Number of Female Employees Exposed 17,756


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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