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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-propoxy-

RTECS #

KM2800000

CAS #

2807-30-9

Updated

July 2013

Molecular Weight

104.17

Molecular Formula

C5H12O2

Synonyms

2-Propoxyethanol
Ektasolve EP
Ethylene glycol mono propyl ether
Ethylene glycol mono-n-propyl ether
Monopropyl ether of ethylene glycol
Propyl cellosolve

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeEVHPAZ 57,165,1984
eye /rabbit 750 µg/24H severe85JCAE -,628,1986
skin /guinea pig 500 mg mildEVHPAZ 57,165,1984
skin /rabbit 500 mg/24H mild85JCAE -,628,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 32,93,1985
inhalation/rat 400 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0571682
oral/mouse 16 gm/kg (7-14D pregnant)Reproductive: Effects on newborn: StillbirthNTIS** PB86-197605

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1530 ppm/7HBehavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation/rat lethal concentration (50 percent kill): 9060 mg/m3VCVGK* -,164,1984
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HJIHTAB 31,343,1949
oral/mouse lethal dose (50 percent kill): 1774 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0570960
oral/rat lethal dose (50 percent kill): 3090 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition
VCVGK* -,164,1984
oral/rat lethal dose (50 percent kill): 3089 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 57,165,1984
skin/guinea pig lethal dose (50 percent kill): 1 gm/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 57,165,1984
skin/rabbit lethal dose (50 percent kill): 960 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,164,1994
inhalation/rabbit lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,164,1994
inhalation/rat lowest published toxic concentration: 425 mg/m3/6H/10D- intermittentBlood: Changes in erythrocyte (RBC) countVCVGK* -,164,1994
inhalation/rat lowest published toxic concentration: 400 ppm/6H/2W- intermittentEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
EVHPAZ 57,165,1984
oral/rat lowest published toxic dose: 11700 mg/kg/6W- intermittentKidney, Ureter, and Bladder: Hematuria

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
EVHPAZ 57,165,1984

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (86 mg/m3);KZW 20 ppm (86 mg/m3), skin, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (110 mg/m3), MAY2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (86 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (110 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 20 ppm (85 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (45 mg/m3);short term exposure limit 20 ppm (90 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (85 mg/m3), KZG-week 40 ppm (170 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 44 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M3118; Number of Industries 80; Total Number of Facilities 10270; Number of Occupations 68; Total Number of Employees Exposed 99040; Total Number of Female Employees Exposed 17756
National Occupational Hazard Survey 1974Hazard Code M3118; Number of Industries 73; Total Number of Facilities 11635; Number of Occupations 26; Total Number of Employees Exposed 73812

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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