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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2,2',2''-nitrilotri-

RTECS #

KL9275000

CAS #

102-71-6

Updated

September 201

Molecular Weight

149.22

Molecular Formula

C6H15NO3

Synonyms

2,2',2''-Nitrilotriethanol
Alkanolamine 244
Daltogen
Nitrilo-2,2',2''-triethanol
Sterolamide
Sting-Kill
TEA (amino alcohol)
Thiofaco T-35
Tri(hydroxyethyl)amine
Triaethanolamin-NG
Triethanolamin
Triethanolamine
Triethanolamine (ACGIH)
Triethylamine, 2,2',2''-trihydroxy-
Triethylolamine
Trihydroxytriethylamine
Tris(2-hydroxyethyl)amine
Trolamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 10 mg mildTXAPA9 55,501,1980
skin /human 15 mg/3D- intermittent mild85DKA8 -,127,1977
skin /mouse 50% severeTOXID9 -,270,2008
skin /rabbit 560 mg/24H mildTXAPA9 19,276,1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 µmol/LBZARAZ 39,422,1986
sister chromatid exchangelymphocyte/human1 mmol/LCYGEDX 21(6),29,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/rat lowest published toxic dose: 129 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-449,1999
skin/rat lowest published toxic dose: 90125 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB2000-102846

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 15 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 2483.6 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lethal dose (50 percent kill): 1450 mg/kgRCRVAB 38,975,1969
intraperitoneal/rat lethal dose (50 percent kill): 1510 mg/kgNTIS** OTS0516797
oral/guinea pig lethal dose (50 percent kill): 2200 mg/kg85GMAT -,114,1982
oral/mammal (species unspecified) lowest published lethal dose: 2 gm/kgNTIS** OTS0520710
oral/mouse lethal dose (50 percent kill): 5846 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes
SRTCAC 36(1-4),10,1989
oral/rabbit lethal dose (50 percent kill): 2200 mg/kg85GMAT -,114,1982
oral/rat lethal dose (50 percent kill): 4920 µL/kgEye: Lacrimation

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0516797
oral/rat lethal dose (50 percent kill): 7.39 gm/kgHPV354 -,-,2003
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 3/18/1965
skin/rat lethal dose (50 percent kill): >2 gm/kgHPV354 -,-,2003
skin/rat lethal dose (50 percent kill): >16 mL/kgNTIS** OTS0516797

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 125 mg/m3/6H/3W- intermittentCardiac: Changes in heart weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0533591
inhalation/rat lowest published toxic concentration: 2 gm/m3/6H/3W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight
NTIS** OTS0533592
inhalation/rat lowest published toxic concentration: 20 mg/m3/6H/28D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationFCTOD7 46,2173,2008
oral/guinea pig lowest published toxic dose: 192 gm/kg/17W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0516740
oral/mouse lowest published toxic dose: 2296 mL/kg/82W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 18,25,1992
oral/rat lowest published toxic dose: 63028 mg/kg/28D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0520455
oral/rat lowest published toxic dose: 96 gm/kg/60D- intermittentKidney, Ureter, and Bladder: Other changesNTIS** OTS0516740
oral/rat lowest published toxic dose: 29700 µg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** OTS0516797
skin/guinea pig lowest published toxic dose: 32 gm/kg/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0516740
skin/mouse lowest published toxic dose: 260 gm/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Skin: After systemic exposure: Dermatitis, other
NTPTR* NTP-TR-449,1999
skin/mouse lowest published toxic dose: 182000 mg/kg/13W- intermittentBehavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004
skin/mouse lowest published toxic dose: 459900 mg/kg/2Y- intermittentVascular: Tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin/mouse lowest published toxic dose: 730000 mg/kg/2Y- intermittentLiver: Tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin/mouse lowest published toxic dose: 2000 mg/kg/17W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* TR-518
skin/mouse lowest published toxic dose: 100 mg/kg/104W- continuousLiver: Tumors

Skin: After topical application: Corrosive
NTPTR* TR-518
skin/mouse lowest published toxic dose: 100 mg/kg/104W- continuousLiver: Other changes

Liver: Tumors
NTPTR* TR-518
skin/mouse lowest published toxic dose: 630 mg/kg/104W- continuousLiver: AngiosarcomaNTPTR* TR-518
skin/rat lowest published toxic dose: 45990 mg/kg/2Y- intermittentKidney, Ureter, and Bladder: Bladder tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin/rat lowest published toxic dose: 45990 mg/kg/2Y- intermittentBehavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004
skin/rat lowest published toxic dose: 22750 mg/kg/13W- intermittentBehavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004
skin/rat lowest published toxic dose: 65 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-449,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 77,564,2000
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWENTOX* -,266,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFEREAC 74,12617,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,282,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.8 ppm (5 mg/m3);KZW 1.6 ppm (10 mg/m3), inhal, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3 (3.1 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 5 mg/m3), inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, sen, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, KZG-week 20 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0260; Number of Industries 311; Total Number of Facilities 70726; Number of Occupations 195; Total Number of Employees Exposed 1726272; Total Number of Female Employees Exposed 573604
National Occupational Hazard Survey 1974Hazard Code M0260; Number of Industries 297; Total Number of Facilities 61500; Number of Occupations 201; Total Number of Employees Exposed 821293

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);equivocal evidence:rat
NCI Carcinogenesis Studies (derm);inadequate study:mouse
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NTP Carcinogenesis studies; on test (two year studies), October 2000
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