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Ethanol, 2,2',2'' - nitrilotri -

RTECS #: KL9275000

CAS #: 102-71-6


UPDATE: May 2009 MW: 149.22 MF: C6H15NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,2',2'' - Nitrilotriethanol
  2. Alkanolamine 244
  3. Daltogen
  4. Nitrilo - 2,2',2'' - triethanol
  5. Sterolamide
  6. Sting - Kill
  7. TEA (amino alcohol)
  8. Thiofaco T - 35
  9. Tri (hydroxyethyl) amine
  1. Triaethanolamin - NG
  2. Triethanolamin
  3. Triethanolamine
  4. Triethanolamine (ACGIH)
  5. Triethylamine, 2,2',2'' - trihydroxy -
  6. Triethylolamine
  7. Trihydroxytriethylamine
  8. Tris (2 - hydroxyethyl) amine
  9. Trolamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
eye
rabbit
10 mg mild TXAPA9 55,501,1980
skin
human
15 mg/3 day- intermittent mild 85DKA8 -,127,1977
skin
mouse
50% severe TOXID9 -,270,2008
skin
rabbit
560 mg/24 hour mild TXAPA9 19,276,1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 mol/L BZARAZ 39,422,1986
sister chromatid exchange human lymphocyte 1 mmol/L CYGEDX 21(6),29,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rat
lowest published toxic dose: 129 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-449,1999
skin
rat
lowest published toxic dose: 90,125 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB2000-102846


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,450 mg/kg N/R RCRVAB 38,975,1969
intraperitoneal
rat
lethal dose (50 percent kill): 1,510 mg/kg N/R NTIS** OTS0516797
oral
guinea pig
lethal dose (50 percent kill): 2,200 mg/kg N/R 85GMAT -,114,1982
oral
mammal (species unspecified)
lowest published lethal dose: 2 gm/kg N/R NTIS** OTS0520710
oral
mouse
lethal dose (50 percent kill): 5,846 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes
SRTCAC 36(1-4),10,1989
oral
rat
lethal dose (50 percent kill): 4,920 L/kg Eye: Lacrimation

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0516797
oral
rabbit
lethal dose (50 percent kill): 2,200 mg/kg N/R 85GMAT -,114,1982
skin
rat
lethal dose (50 percent kill): >16 mL/kg N/R NTIS** OTS0516797
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 3/18/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 125 mg/m3/6 hour/3 week- intermittent Cardiac: Changes in heart weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0533591
inhalation
rat
lowest published toxic concentration: 2 gm/m3/6 hour/3 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight
NTIS** OTS0533592
inhalation
rat
lowest published toxic concentration: 20 mg/m3/6 hour/28 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FCTOD7 46,2173,2008
oral
guinea pig
lowest published toxic dose: 192 gm/kg/17 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0516740
oral
mouse
lowest published toxic dose: 2,296 mL/kg/82 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 18,25,1992
oral
rat
lowest published toxic dose: 63,028 mg/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0520455
oral
rat
lowest published toxic dose: 96 gm/kg/60 day- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** OTS0516740
oral
rat
lowest published toxic dose: 29,700 g/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** OTS0516797
skin
guinea pig
lowest published toxic dose: 32 gm/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0516740
skin
mouse
lowest published toxic dose: 260 gm/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Skin: After systemic exposure: Dermatitis, other
NTPTR* NTP-TR-449,1999
skin
mouse
lowest published toxic dose: 182,000 mg/kg/13 week- intermittent Behavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004
skin
mouse
lowest published toxic dose: 459,900 mg/kg/2 year- intermittent Vascular: Tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin
mouse
lowest published toxic dose: 730,000 mg/kg/2 year- intermittent Liver: Tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin
mouse
lowest published toxic dose: 2,000 mg/kg/17 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-518
skin
mouse
lowest published toxic dose: 100 mg/kg/104 week- continuous Liver: Tumors

Skin: After topical application: Corrosive
NTPTR* TR-518
skin
mouse
lowest published toxic dose: 100 mg/kg/104 week- continuous Liver: Other changes

Liver: Tumors
NTPTR* TR-518
skin
mouse
lowest published toxic dose: 630 mg/kg/104 week- continuous Liver: Angiosarcoma NTPTR* TR-518
skin
rat
lowest published toxic dose: 65 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-449,1999
skin
rat
lowest published toxic dose: 22,750 mg/kg/13 week- intermittent Behavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004
skin
rat
lowest published toxic dose: 45,990 mg/kg/2 year- intermittent Kidney, Ureter, and Bladder: Bladder tumors

Skin: After topical application: Primary irritation

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,112,2004
skin
rat
lowest published toxic dose: 45,990 mg/kg/2 year- intermittent Behavioral: Irritability

Skin: After topical application: Primary irritation
TOXID9 78,112,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
ENTOX* -,266,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,282,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3 (3.1 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0260;
Number of Industries 297;
Total Number of Facilities 61,500;
Number of Occupations 201;
Total Number of Employees Exposed 821,293
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0260;
Number of Industries 311;
Total Number of Facilities 70,726;
Number of Occupations 195;
Total Number of Employees Exposed 1,726,272;
Total Number of Female Employees Exposed 573,604


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as lubricant and corrosion inhibitor and in production of shampoos, creams and soaps
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NCI Carcinogenesis Studies (derm);equivocal evidence:rat
NCI Carcinogenesis Studies (derm);inadequate study:mouse
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCRVAB Russian Chemical Reviws (English Translation). Translation of USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.29- 1960-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as lubricant and corrosion inhibitor and in production of shampoos, creams and soaps

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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