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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2,2'-(methylimino)di-

RTECS #

KL7525000

CAS #

105-59-9

Updated

February 2006

Molecular Weight

119.19

Molecular Formula

C5H13NO2

Synonyms

2-(N-2-Hydroxyethyl-N-methylamino)ethanol
2,2'-(Methylimino)diethanol
Bis(2-hydroxyethyl)methylamine
Diethanolmethylamine
Ethanol, 2,2'-(methylimino)bis-
MDEA
Methylbis(2-hydroxyethyl)amine
Methyldiethanolamine
Methyliminodiethanol
N,N-Di(2-hydroxyethyl)-N-methylamine
N-Methyl-2,2'-iminodiethanol
N-Methylaminodiglycol
N-Methyldiethanolamine
N-Methyldiethanolimine
N-Methyliminodiethanol
USAF DO-52

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 µL mildVHTODE 38,422,1996
skin /rabbit 502 mg open irritation test mildUCDS** 7/13/1971
skin /rabbit 500 µL mildVHTODE 38,422,1996

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
skin/rat 10 gm/kg (6-15D pregnant)Reproductive: Other effects on femaleJTOTDO 17,179,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >6500 µg/m3/6HJTOTDO 17,179,1990
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgUSXXAM #6582498
oral/rat lethal dose (50 percent kill): 1945 mg/kgEye: Chromodacryorrhea

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
VHTODE 38,422,1996
oral/rat lethal dose (50 percent kill): 4780 mg/kgUSXXAM #6582498
skin/rabbit lethal dose (50 percent kill): 5990 µL/kgAMIHBC 10,61,1954

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rat lowest published toxic dose: 9360 mg/kg/11D- intermittentBehavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTOTDO 16,157,1997
skin/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 16,157,1997
skin/rat lowest published toxic dose: 9360 mg/kg/9D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
JTOTDO 17,179,1990

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82845; Number of Industries 5; Total Number of Facilities 203; Number of Occupations 6; Total Number of Employees Exposed 6811; Total Number of Female Employees Exposed 1031
National Occupational Hazard Survey 1974Hazard Code 82845; Number of Industries 5; Total Number of Facilities 59; Number of Occupations 15; Total Number of Employees Exposed 1677

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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