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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-

RTECS #

KL6390000

CAS #

112-35-6

Updated

April 2013

Molecular Weight

164.23

Molecular Formula

C7H16O4

Synonyms

2-(2-(2-Methoxyethoxy)ethoxy)ethanol
3,6,9-Trioxa-1-decanol
Dowanol TMAT
Methoxytriglycol
Poly-Solv TM
Triethylene glycolmonomethyl ether
Triglycol monomethyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,634,1986
skin /rabbit 10 mg/24H open irritation test mildAIHAAP 23,95,1962
skin /rabbit 500 mg/24H mild85JCAE -,634,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
heritable translocation testskin/Drosophila melanogaster0.66 mmol/LTOXID9 78,265,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 360 gm/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductNTIS** OTS0526404-2
oral/rat 111 gm/kg (6-21D preg/21D after birth)Reproductive: Other effects on femaleNTIS** OTS0526404-2

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 11300 µL/kgAIHAAP 23,95,1962
skin/rabbit lethal dose (50 percent kill): 7100 µL/kgAIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 36400 mg/kg/13W- continuousLiver: Other changesIJTOFN 17,1,1998

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 50 mg/m3), inhal, 2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0892; Number of Industries 22; Total Number of Facilities 2416; Number of Occupations 29; Total Number of Employees Exposed 18956; Total Number of Female Employees Exposed 9842
National Occupational Hazard Survey 1974Hazard Code M0892; Number of Industries 85; Total Number of Facilities 13261; Number of Occupations 32; Total Number of Employees Exposed 80404

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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