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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(2-methoxyethoxy)-

RTECS #

KL6125000

CAS #

111-77-3

Updated

April 2012

Molecular Weight

120.17

Molecular Formula

C5H12O3

Synonyms

2-(2-Methoxyethoxy)ethanol
beta-Methoxy-beta'-hydroxydiethyl ether
Diethylene glycol methyl ether
Diethylene glycol monomethyl ether
Diglycol monomethyl ether
Dowanol 16
Dowanol DM
Ethylene diglycol monomethyl ether
MECB
Methoxydiglycol
Methyl carbitol
Methyl karbitol (Czech)
Poly-Solv DM

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg moderateUCDS** 4/21/1967
eye /rabbit 500 mg/24H mild85JCAE -,628,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19800 mg/kg (7-17D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
AECTCV 24,228,1993
oral/rat 21650 mg/kg (7-16D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FAATDF 6,430,1986
oral/rat 19800 mg/kg (7-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
AECTCV 24,228,1993
oral/rat 6600 mg/kg (7-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Physical
AECTCV 24,228,1993
oral/mouse 32 gm/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
EVHPAZ 57,141,1984
oral/mouse 32000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
EVHPAZ 57,141,1984
skin/rabbit 3250 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFAATDF 7,68,1986
skin/rabbit 13 gm/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0520312

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >2 gm/m3/1HNTIS** OTS0516703
intraperitoneal/mouse lethal dose (50 percent kill): 2611 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
GNAMAP 29,37,1990
intraperitoneal/rat lethal dose (50 percent kill): 2722 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
GNAMAP 29,37,1990
oral/guinea pig lethal dose (50 percent kill): 4160 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 8222 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
GNAMAP 29,37,1990
oral/rabbit lethal dose (50 percent kill): 7190 mg/kgNTIS** OTS0516797
oral/rat lethal dose (50 percent kill): 4 mL/kgNTIS** OTS0520737
skin/rabbit lethal dose (50 percent kill): 2500 µL/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0516797

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/rat lowest published toxic dose: 107 gm/kg/6W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570960
oral/rat lowest published toxic dose: 5052 mg/kg/30D- continuousBlood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other proteins
GNAMAP 29,37,1990
oral/rat lowest published toxic dose: 40 gm/kg/4W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TXCYAC 76,49,1992
oral/rat lowest published toxic dose: 40 gm/kg/20D- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
BECTA6 44,602,1990
skin/guinea pig lowest published toxic dose: 65 gm/kg/13W- intermittentEndocrine: Changes in spleen weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FAATDF 6,339,1986

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (50.1 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (50.1 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (50.1 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 50.1 mg/m3 (10 ppm), skin, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (50.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 45 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (51 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83736; Number of Industries 134; Total Number of Facilities 19501; Number of Occupations 89; Total Number of Employees Exposed 290501; Total Number of Female Employees Exposed 50151
National Occupational Hazard Survey 1974Hazard Code 83736; Number of Industries 67; Total Number of Facilities 9648; Number of Occupations 47; Total Number of Employees Exposed 59491

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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