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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-mercapto-

RTECS #

KL5600000

CAS #

60-24-2

Updated

November 2007

Molecular Weight

78.14

Molecular Formula

C2H6OS

Synonyms

1-Ethanol-2-thiol
2-Hydroxy-1-ethanethiol
2-Hydroxyethyl mercaptan
2-ME
2-Mercaptoethanol
2-Thioethanol
beta-Mercaptoethanol
Emery 5791
Ethylene glycol, monothio-
Mercaptoethanol
Monothioethyleneglycol
Thiomonoglycol
USAF EK-4196

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 2 mg severeAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Other microorganisms10 mmol/LBBRCA9 77,1150,1977
DNA inhibitionliver/rat1 mmol/LABBIA4 166,400,1975
micronucleus testother cell types/mouse100 mg/LJNCIAM 56,357,1976
Unscheduled DNA Synthesisother cell types/mouse30 mmol/LBBACAQ 425,1,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 13200 mg/m3Lung, Thorax, or Respiration: Respiratory depressionGTPZAB 15(2),56,1971
inhalation/rat Lowest published lethal concentration: 250 ppm/8HUCDS** 3/23/1973
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 190 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 15(2),56,1971
oral/mouse lethal dose (50 percent kill): 348 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
ENTOX* -,32,2005
oral/rat lethal dose (50 percent kill): 244 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 15(2),56,1971
skin/guinea pig lethal dose (50 percent kill): 300 µL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 150 µL/kgUCDS** 3/23/1973
unreported route/mouse lethal dose (50 percent kill): 480 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JPMSAE 62,237,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 3220 mg/kg/4W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPMSAE 62,237,1973
oral/rat lowest published toxic dose: 2450 mg/kg/7W- intermittentLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 90,191,2006
oral/rat lowest published toxic dose: 3675 mg/kg/7W- intermittentCardiac: Cardiomyopathy including infarction

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 90,191,2006
oral/rat lowest published toxic dose: 950 mg/kg/19D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 90,191,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,32,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84674; Number of Industries 5; Total Number of Facilities 1497; Number of Occupations 13; Total Number of Employees Exposed 14140; Total Number of Female Employees Exposed 4607
National Occupational Hazard Survey 1974Hazard Code 84674; Number of Industries 4; Total Number of Facilities 133; Number of Occupations 6; Total Number of Employees Exposed 1437

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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