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Ethanol, 2 - mercapto -

RTECS #: KL5600000

CAS #: 60-24-2


UPDATE: November 2007 MW: 78.14 MF: C2H6OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Ethanol - 2 - thiol
  2. 2 - Hydroxy - 1 - ethanethiol
  3. 2 - Hydroxyethyl mercaptan
  4. 2 - ME
  5. 2 - Mercaptoethanol
  6. 2 - Thioethanol
  7. Emery 5791
  1. Ethylene glycol, monothio -
  2. Mercaptoethanol
  3. Monothioethyleneglycol
  4. Thiomonoglycol
  5. USAF EK - 4196
  6. beta - Mercaptoethanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
2 mg severe AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 26,269,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage other microorganisms 10 mmol/L BBRCA9 77,1150,1977
DNA inhibition rat liver 1 mmol/L ABBIA4 166,400,1975
unscheduled DNA synthesis mouse other cell types 30 mmol/L BBACAQ 425,1,1976
micronucleus test mouse other cell types 100 mg/L JNCIAM 56,357,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 13,200 mg/m3 Lung, Thorax, or Respiration: Respiratory depression GTPZAB 15(2),56,1971
inhalation
rat
lowest published lethal concentration: 250 ppm/8 hour N/R UCDS** 3/23/1973
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
oral
mouse
lethal dose (50 percent kill): 190 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 15(2),56,1971
oral
mouse
lethal dose (50 percent kill): 348 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
ENTOX* -,32,2005
oral
rat
lethal dose (50 percent kill): 244 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 15(2),56,1971
skin
guinea pig
lethal dose (50 percent kill): 300 ÁL/kg N/R JIHTAB 26,269,1944
skin
rabbit
lethal dose (50 percent kill): 150 ÁL/kg N/R UCDS** 3/23/1973
unreported route
mouse
lethal dose (50 percent kill): 480 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
JPMSAE 62,237,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 3,220 mg/kg/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPMSAE 62,237,1973
oral
rat
lowest published toxic dose: 2,450 mg/kg/7 week- intermittent Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 90,191,2006
oral
rat
lowest published toxic dose: 3,675 mg/kg/7 week- intermittent Cardiac: Cardiomyopathy including infarction

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 90,191,2006
oral
rat
lowest published toxic dose: 950 mg/kg/19 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 90,191,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,32,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84674;
Number of Industries 4;
Total Number of Facilities 133;
Number of Occupations 6;
Total Number of Employees Exposed 1,437
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84674;
Number of Industries 5;
Total Number of Facilities 1,497;
Number of Occupations 13;
Total Number of Employees Exposed 14,140;
Total Number of Female Employees Exposed 4,607


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chain transfer agent, intermediate for dyestuffs, rubber chemicals, plasticizers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as chain transfer agent, intermediate for dyestuffs, rubber chemicals, plasticizers

RTECS Compound Description:
   Mutagen
   Primary Irritant

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