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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-((2-hexyloxy)ethoxy)-

RTECS #

KL2625000

CAS #

112-59-4

Updated

February 2003

Molecular Weight

190.32

Molecular Formula

C10H22O3

Synonyms

2-((2-Hexyloxy)ethoxy)ethanol
3,6-Dioxa-1-dodecanol
3,6-Dioxadodecanol-1
Diethylene glycol monohexyl ether
Diethylene glycol n-hexyl ether
Hexyl carbitol
Hexylkarbitol (Czech)
n-Hexoxyethoxyethanol
n-Hexyl carbitol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg moderateUCDS** 11/3/1971
eye /rabbit 750 µg/24H severe85JCAE -,640,1986
skin /rabbit 10 mg/24H open irritation test mildAMIHBC 4,119,1951
skin /rabbit 500 mg/24H severeJPETAB 82,377,1944
skin /rabbit 500 mg open irritation test mildUCDS** 11/3/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat375 mg/kg (+enzymatic activation step)JAPTO* 21,449,2001
mutation in mammalian somatic cellsovary/hamster250 mg/L/5H (-enzymatic activation step)JAPTO* 21,449,2001
mutation in mammalian somatic cellsovary/hamster750 mg/L/5H (+enzymatic activation step)JAPTO* 21,449,2001
sister chromatid exchangeovary/hamster1500 mg/L/2H (+enzymatic activation step)JAPTO* 21,449,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 715 mg/kgJAPTO* 21,449,2001
intraperitoneal/rat lethal dose (50 percent kill): 1823 mg/kgJAPTO* 21,449,2001
oral/mouse lowest published lethal dose: 3160 µL/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Blood: Other changes
NTIS** OTS0538680
oral/rat lethal dose (50 percent kill): 2400 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0538682
skin/rabbit lethal dose (50 percent kill): 1500 µL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rabbit lowest published toxic dose: 18 mL/kg/11D- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 14,219,1995

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4280; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 18
National Occupational Hazard Survey 1974Hazard Code M4280; Number of Industries 4; Total Number of Facilities 85; Number of Occupations 10; Total Number of Employees Exposed 808

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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