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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(hexyloxy)-

RTECS #

KL2450000

CAS #

112-25-4

Updated

November 2009

Molecular Weight

146.26

Molecular Formula

C8H18O2

Synonyms

2-(Hexyloxy)ethanol
Cellosolve, N-hexyl-
Ethylene glycol monohexyl ether
Ethylene glycol n-hexyl ether
Glycol monohexyl ether
Hexyl cellosolve
n-Hexyl cellosolve

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg mildUCDS** 1/19/1958
skin /rabbit 500 mg open irritation test mildUCDS** 1/19/1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >83 ppm/4HFAATDF 8,198,1987
intraperitoneal/mouse lethal dose (50 percent kill): 737 mg/kgARTODN 66,368,1992
intravenous/rabbit lethal dose (50 percent kill): 30.3 mg/kgJAPTO* 23,301,2003
intravenous/rat lethal dose (50 percent kill): 53.6 mg/kgJAPTO* 23,301,2003
oral/rat lethal dose (50 percent kill): 830 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
VHTODE 29,361,1987
skin/rabbit lethal dose (50 percent kill): 810 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands

Skin: After systemic exposure: Dermatitis, other
VHTODE 29,361,1987
skin/rabbit lethal dose (50 percent kill): 720 mg/kgJAPTO* 23,301,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 41 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 23,301,2003
inhalation/rat lowest published toxic concentration: 84 ppm/6H/11D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 8,198,1987
inhalation/rat lowest published toxic concentration: 41 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 8,198,1987
skin/rabbit lowest published toxic dose: 18 mL/kg/11D- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 14,219,1995
skin/rabbit lowest published toxic dose: 176 mg/kg/4D- intermittentSkin: After topical application: Primary irritationJAPTO* 23,301,2003
skin/rabbit lowest published toxic dose: 132 mg/kg/3D- intermittentSkin: After topical application: Primary irritationJAPTO* 23,301,2003
skin/rabbit lowest published toxic dose: 2220 mg/kg/1W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 23,301,2003
skin/rabbit lowest published toxic dose: 3108 mg/kg/9D- intermittentBlood: Other changes

Blood: Changes in erythrocyte (RBC) count
JAPTO* 23,301,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M3116; Number of Industries 5; Total Number of Facilities 31; Number of Occupations 7; Total Number of Employees Exposed 2872; Total Number of Female Employees Exposed 45
National Occupational Hazard Survey 1974Hazard Code M3116; Number of Industries 3; Total Number of Facilities 269; Number of Occupations 4; Total Number of Employees Exposed 3496

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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