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Ethanol, 2 - (hexyloxy) -

RTECS #: KL2450000

CAS #: 112-25-4


UPDATE: May 2006 MW: 146.26 MF: C8H18O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - (Hexyloxy) ethanol
  2. Cellosolve, N - hexyl -
  3. Ethylene glycol n - hexyl ether
  4. Ethylene glycol monohexyl ether
  1. Glycol monohexyl ether
  2. Hexyl cellosolve
  3. n - Hexyl cellosolve


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1 mg mild UCDS** 1/19/1958
skin
rabbit
500 mg open irritation test mild UCDS** 1/19/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration : >83 ppm/4 hour N/R FAATDF 8,198,1987
intraperitoneal
mouse
lethal dose (50 percent kill): 737 mg/kg N/R ARTODN 66,368,1992
intravenous
rat
lethal dose (50 percent kill): 53.6 mg/kg N/R JAPTO* 23,301,2003
intravenous
rabbit
lethal dose (50 percent kill): 30.3 mg/kg N/R JAPTO* 23,301,2003
oral
rat
lethal dose (50 percent kill): 830 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
VHTODE 29,361,1987
skin
rabbit
lethal dose (50 percent kill): 810 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands

Skin: After systemic exposure: Dermatitis, other
VHTODE 29,361,1987
skin
rabbit
lethal dose (50 percent kill): 720 mg/kg N/R JAPTO* 23,301,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 84 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 8,198,1987
inhalation
rat
lowest published toxic concentration: 41 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 8,198,1987
inhalation
rat
lowest published toxic concentration: 41 ppm/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 23,301,2003
skin
rabbit
lowest published toxic dose: 18 mL/kg/11 day- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 14,219,1995
skin
rabbit
lowest published toxic dose: 176 mg/kg/4 day- intermittent Skin: After topical application: Primary irritation JAPTO* 23,301,2003
skin
rabbit
lowest published toxic dose: 132 mg/kg/3 day- intermittent Skin: After topical application: Primary irritation JAPTO* 23,301,2003
skin
rabbit
lowest published toxic dose: 2,220 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 23,301,2003
skin
rabbit
lowest published toxic dose: 3,108 mg/kg/9 day- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
JAPTO* 23,301,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3116;
Number of Industries 3;
Total Number of Facilities 269;
Number of Occupations 4;
Total Number of Employees Exposed 3,496
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3116;
Number of Industries 5;
Total Number of Facilities 31;
Number of Occupations 7;
Total Number of Employees Exposed 2,872;
Total Number of Female Employees Exposed 45


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent in the coating industry
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as solvent in the coating industry

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

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