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Ethanol, 2 - (2 - (2 - ethoxyethoxy) ethoxy) -

RTECS #: KK8950000

CAS #: 112-50-5


UPDATE: February 2006 MW: 178.26 MF: C8H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - (2 - (2 - Ethoxyethoxy) ethoxy) ethanol
  2. 3,6,9 - Trioxaundecanol
  3. Dowanol TE
  4. Ethoxytriethylene glycol
  5. Ethoxytriglycol
  1. Poly - Solv TE
  2. Triethylene glycol ethyl ether
  3. Triethylene glycol monoethyl ether
  4. Triglycol monoethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg mild AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
guinea pig
lethal dose (50 percent kill): 3,070 mg/kg N/R VCVGK* -,175,1984
oral
mouse
lethal dose (50 percent kill): 5,798 mg/kg N/R VCVGK* -,175,1984
oral
rat
lethal dose (50 percent kill): 7,750 mg/kg N/R VCVGK* -,175,1984
skin
rabbit
lethal dose (50 percent kill): 8 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 141 mg/kg/26 week- intermittent Blood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(5),84,1982
oral
rat
lowest published toxic dose: 930 mg/kg/30 day- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count
VCVGK* -,175,1994
oral
rat
lowest published toxic dose: 141 mg/kg/26 week- intermittent Blood: Changes in cell count (unspecified)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,175,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2556;
Number of Industries 83;
Total Number of Facilities 12,848;
Number of Occupations 25;
Total Number of Employees Exposed 81,218
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2556;
Number of Industries 3;
Total Number of Facilities 70;
Number of Occupations 3;
Total Number of Employees Exposed 621;
Total Number of Female Employees Exposed 44


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chemical intermediate, reaction media, solvent for paints, lacquers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as chemical intermediate, reaction media, solvent for paints, lacquers and resins

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

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