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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(2-(2-ethoxyethoxy)ethoxy)-

RTECS #

KK8950000

CAS #

112-50-5

Updated

February 2006

Molecular Weight

178.26

Molecular Formula

C8H18O4

Synonyms

2-(2-(2-Ethoxyethoxy)ethoxy)ethanol
3,6,9-Trioxaundecanol
Dowanol TE
Ethoxytriethylene glycol
Ethoxytriglycol
Poly-Solv TE
Triethylene glycol ethyl ether
Triethylene glycol monoethyl ether
Triglycol monoethyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 3070 mg/kgVCVGK* -,175,1984
oral/mouse lethal dose (50 percent kill): 5798 mg/kgVCVGK* -,175,1984
oral/rat lethal dose (50 percent kill): 7750 mg/kgVCVGK* -,175,1984
skin/rabbit lethal dose (50 percent kill): 8 mL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 141 mg/kg/26W- intermittentBlood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(5),84,1982
oral/rat lowest published toxic dose: 930 mg/kg/30D- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count
VCVGK* -,175,1994
oral/rat lowest published toxic dose: 141 mg/kg/26W- intermittentBlood: Changes in cell count (unspecified)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,175,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M2556; Number of Industries 3; Total Number of Facilities 70; Number of Occupations 3; Total Number of Employees Exposed 621; Total Number of Female Employees Exposed 44
National Occupational Hazard Survey 1974Hazard Code M2556; Number of Industries 83; Total Number of Facilities 12848; Number of Occupations 25; Total Number of Employees Exposed 81218

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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