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Ethanol, 2 - (2 - ethoxyethoxy) -

RTECS #: KK8750000

CAS #: 111-90-0


UPDATE: May 2008 MW: 134.20 MF: C6H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - (2 - Ethoxyethoxy) ethanol
  2. 3,6 - Dioxa - 1 - octanol
  3. 3,6 - Dioxa - 1 - oktanol (Czech)
  4. Aethyldiaethylenglycol (German)
  5. Carbitol
  6. Diethylene glycol ethyl ether
  7. Diethylene glycol monoethyl ether
  8. Diglycol monoethyl ether
  9. Dioxitol
  10. Dowanol 17
  11. Dowanol DE
  12. Ektasolve DE
  1. Ethoxy diglycol
  2. Ethyl carbitol
  3. Ethyl diethylene glycol
  4. Ethyl digol
  5. Ethylene diglycol monoethyl ether
  6. Karbitol (Czech)
  7. Losungsmittel APV
  8. Monoethyl ether of diethylene glycol
  9. PM 1799
  10. Poly - Solv DE
  11. Solvolsol
  12. Transcutol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg moderate UCDS** 11/22/1968
eye
rabbit
125 mg mild ADSYAF 45,553,1942
skin
rabbit
500 mg/24 hour mild JPETAB 82,377,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 986 mg/plate (+/-enzymatic activation step) BCFAAI 125,401,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 44 gm/kg (7-14 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 32 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral
mouse
lowest published toxic dose: 246 gm/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
FAATDF 14,622,1990
oral
mouse
lowest published toxic dose: 44,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 3 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB85137123
oral
mouse
lowest published toxic dose: 3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB85137123
oral
mouse
lowest published toxic dose: 3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
NTIS** #PB85137123
oral
mouse
lowest published toxic dose: 11 gm/kg (7 day male/7 day prior to copulation/3 week pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB85137123


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >5,240 mg/m3/4 hour Liver: Other changes BGTOX* 5,91,1993
intraperitoneal
mouse
lethal dose (50 percent kill): 2,300 mg/kg Eye: Ptosis

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
PHTHDT 5,467,1979
intraperitoneal
rat
lethal dose (50 percent kill): 360 痢/kg N/R NTIS** OTS0516797
intravenous
cat
lowest published lethal dose: 1 gm/kg Behavioral: Altered sleep time (including change in righting reflex) ARZNAD 28,1571,1978
intravenous
dog
lethal dose (50 percent kill): 3 mL/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
intravenous
mouse
lethal dose (50 percent kill): 4,300 無/kg N/R JPETAB 65,89,1939
intravenous
rat
lethal dose (50 percent kill): 4 gm/kg N/R NTIS** OTS0516797
intravenous
rabbit
lethal dose (50 percent kill): 2,500 無/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
oral
guinea pig
lethal dose (50 percent kill): 3,700 無/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
guinea pig
lethal dose (50 percent kill): 3,000 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
oral
man
lowest published toxic dose: 2 mL/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,173,1984
oral
mouse
lethal dose (50 percent kill): 6,600 無/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Coma
JIHTAB 21,173,1939
oral
mouse
lethal dose (50 percent kill): 7,250 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
oral
rat
lethal dose (50 percent kill): 5,500 無/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Coma
JIHTAB 21,173,1939
oral
rat
lethal dose (50 percent kill): 7,500 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
oral
rabbit
lethal dose (50 percent kill): 3,620 mg/kg N/R NTIS** OTS0516797
subcutaneous
mouse
lethal dose (50 percent kill): 5,500 無/kg N/R JPETAB 65,89,1939
subcutaneous
rat
lethal dose (50 percent kill): 6 gm/kg N/R BCFAAI 125,401,1986
skin
guinea pig
lethal dose (50 percent kill): >32 gm/kg N/R NTIS** OTS0516797
skin
mouse
lethal dose (50 percent kill): 6 mL/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
skin
rat
lethal dose (50 percent kill): 6 mL/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
skin
rabbit
lethal dose (50 percent kill): 4,200 無/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0516797
skin
rabbit
lethal dose (50 percent kill): 8.5 mL/kg/2 hour N/R VCVGK* -,173,1984
unreported route
guinea pig
lethal dose (50 percent kill): 3 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GISAAA 46(4),74,1981
unreported route
mammal (species unspecified)
lowest published lethal dose: 2 mL/kg N/R VCVGK* -,173,1984
unreported route
mouse
lethal dose (50 percent kill): 7,150 mg/kg N/R GISAAA 46(2),14,1981
unreported route
rat
lethal dose (50 percent kill): 7,500 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GISAAA 46(4),74,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5 mg/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 46(2),14,1981
inhalation
rat
lowest published toxic concentration: 25 mg/m3/122 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,173,1994
oral
mouse
lowest published toxic dose: 583 gm/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 6,689,1968
oral
mouse
lowest published toxic dose: 44,000 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 67.2 gm/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB85137123
oral
pig
lowest published toxic dose: 100 gm/kg/90 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 6,689,1968
oral
rat
lowest published toxic dose: 692 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0516797
oral
rat
lowest published toxic dose: 225 gm/kg/90 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 6,689,1968
oral
rat
lowest published toxic dose: 158 gm/kg/6 week- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Hematuria

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0570960
oral
rat
lowest published toxic dose: 900 mg/kg/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in bone marrow not included in above
VCVGK* -,173,1994
oral
rat
lowest published toxic dose: 13,650 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,173,1994
skin
rat
lowest published toxic dose: 65 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Other changes BGTOX* 5,91,1993
skin
rabbit
lowest published toxic dose: 26,700 無/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 29,325,1947
skin
rabbit
lowest published toxic dose: 9.6 mL/kg/30 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,173,1994
unreported route
rat
lowest published toxic dose: 1,365 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 46(4),71,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JACTDZ 4(5),223,1985
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
ENTOX* -,451,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 180 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 15 ppm (80 mg/m3);
short term exposure limit 30 ppm (170 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 mg/m3,KZG- week 100 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83102;
Number of Industries 218;
Total Number of Facilities 38,144;
Number of Occupations 126;
Total Number of Employees Exposed 352,049
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83102;
Number of Industries 204;
Total Number of Facilities 36,712;
Number of Occupations 133;
Total Number of Employees Exposed 576,488;
Total Number of Female Employees Exposed 222,885


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as diluent for hydraulic brake fluids and solvent for protective coatings and cosmetics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
BGTOX* BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. (Springer-Verlag New York, POB 2485, Secaucus, NJ 07096).
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.4- 1979-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as diluent for hydraulic brake fluids and solvent for protective coatings and cosmetics

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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