Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(2-ethoxyethoxy)-

RTECS #

KK8750000

CAS #

111-90-0

Updated

July 2013

Molecular Weight

134.20

Molecular Formula

C6H14O3

Synonyms

2-(2-Ethoxyethoxy)ethanol
3,6-Dioxa-1-octanol
3,6-Dioxa-1-oktanol (Czech)
Aethyldiaethylenglycol (German)
Carbitol
Diethylene glycol ethyl ether
Diethylene glycol monoethyl ether
Diglycol monoethyl ether
Dioxitol
Dowanol 17
Dowanol DE
Ektasolve DE
Ethoxy diglycol
Ethyl carbitol
Ethyl diethylene glycol
Ethyl digol
Ethylene diglycol monoethyl ether
Karbitol (Czech)
Losungsmittel APV
Monoethyl ether of diethylene glycol
PM 1799
Poly-Solv DE
Solvolsol
Transcutol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg moderateUCDS** 11/22/1968
eye /rabbit 125 mg mildADSYAF 45,553,1942
skin /rabbit 500 mg/24H mildJPETAB 82,377,1944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium986 mg/plate (+/-enzymatic activation step)BCFAAI 125,401,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 44 gm/kg (7-14D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EVHPAZ 57,141,1984
oral/mouse 32 gm/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral/mouse 246 gm/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
FAATDF 14,622,1990
oral/mouse 44000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsEVHPAZ 57,141,1984
oral/mouse 3 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85137123
oral/mouse 3 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB85137123
oral/mouse 3 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
NTIS** #PB85137123
oral/mouse 11 gm/kg (7D male/7D prior to copulation/3W pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85137123

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 174 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/rat lethal concentration (50 percent kill): >5240 mg/m3/4HLiver: Other changesBGTOX* 5,91,1993
intraperitoneal/mouse lethal dose (50 percent kill): 2300 mg/kgEye: Ptosis

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
PHTHDT 5,467,1979
intraperitoneal/rat lethal dose (50 percent kill): 360 µg/kgNTIS** OTS0516797
intravenous/cat lowest published lethal dose: 1 gm/kgBehavioral: Altered sleep time (including change in righting reflex)ARZNAD 28,1571,1978
intravenous/Dog lethal dose (50 percent kill): 3 mL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
intravenous/mouse lethal dose (50 percent kill): 4300 µL/kgJPETAB 65,89,1939
intravenous/rabbit lethal dose (50 percent kill): 2500 µL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
intravenous/rat lethal dose (50 percent kill): 4 gm/kgNTIS** OTS0516797
oral/guinea pig lethal dose (50 percent kill): 3700 µL/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lethal dose (50 percent kill): 3000 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
oral/man lowest published toxic dose: 2 mL/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,173,1984
oral/mouse lethal dose (50 percent kill): 7250 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
oral/mouse lethal dose (50 percent kill): 6600 µL/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Coma
JIHTAB 21,173,1939
oral/rabbit lethal dose (50 percent kill): 3620 mg/kgNTIS** OTS0516797
oral/rat lethal dose (50 percent kill): 5500 µL/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Coma
JIHTAB 21,173,1939
oral/rat lethal dose (50 percent kill): 7500 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,173,1984
skin/guinea pig lethal dose (50 percent kill): >32 gm/kgNTIS** OTS0516797
skin/mouse lethal dose (50 percent kill): 6 mL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
skin/rabbit lethal dose (50 percent kill): 4200 µL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0516797
skin/rabbit lethal dose (50 percent kill): 8.5 mL/kg/2HVCVGK* -,173,1984
skin/rat lethal dose (50 percent kill): 6 mL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
JIHTAB 29,190,1947
subcutaneous/mouse lethal dose (50 percent kill): 5500 µL/kgJPETAB 65,89,1939
subcutaneous/rat lethal dose (50 percent kill): 6 gm/kgBCFAAI 125,401,1986
unreported route/guinea pig lethal dose (50 percent kill): 3 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GISAAA 46(4),74,1981
unreported route/mammal (species unspecified) lowest published lethal dose: 2 mL/kgVCVGK* -,173,1984
unreported route/mouse lethal dose (50 percent kill): 7150 mg/kgGISAAA 46(2),14,1981
unreported route/rat lethal dose (50 percent kill): 7500 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GISAAA 46(4),74,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/24H/17W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 46(2),14,1981
inhalation/rat lowest published toxic concentration: 25 mg/m3/122D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,173,1994
oral/mouse lowest published toxic dose: 67.2 gm/kg/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB85137123
oral/mouse lowest published toxic dose: 583 gm/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 6,689,1968
oral/mouse lowest published toxic dose: 44000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/pig lowest published toxic dose: 100 gm/kg/90D- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 6,689,1968
oral/rat lowest published toxic dose: 13650 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,173,1994
oral/rat lowest published toxic dose: 900 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in bone marrow not included in above
VCVGK* -,173,1994
oral/rat lowest published toxic dose: 692 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0516797
oral/rat lowest published toxic dose: 225 gm/kg/90D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 6,689,1968
oral/rat lowest published toxic dose: 158 gm/kg/6W- intermittentBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Hematuria

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0570960
skin/rabbit lowest published toxic dose: 9.6 mL/kg/30D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,173,1994
skin/rabbit lowest published toxic dose: 26700 µL/kg/30D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 29,325,1947
skin/rat lowest published toxic dose: 65 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Other changesBGTOX* 5,91,1993
unreported route/rat lowest published toxic dose: 1365 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 46(4),71,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 4(5),223,1985
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 50 mg/m3 (inhal.), 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 15 ppm (80 mg/m3);short term exposure limit 30 ppm (170 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 mg/m3, KZG-week 100 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 180 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83102; Number of Industries 204; Total Number of Facilities 36712; Number of Occupations 133; Total Number of Employees Exposed 576488; Total Number of Female Employees Exposed 222885
National Occupational Hazard Survey 1974Hazard Code 83102; Number of Industries 218; Total Number of Facilities 38144; Number of Occupations 126; Total Number of Employees Exposed 352049

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
TOP