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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-dimethylamino-

RTECS #

KK6125000

CAS #

108-01-0

Updated

March 2011

Molecular Weight

89.16

Molecular Formula

C4H11NO

Synonyms

2-(Dimethylamino)ethanol
2-Dimethylaminoethanol
2-Dwumetyloaminoetanolu (Polish)
Amietol M 21
beta-Dimethylaminoethanol
beta-Dimethylaminoethyl alcohol
beta-Hydroxyethyldimethylamine
Bimanol
Deanol
Dimethylaethanolamin (German)
Dimethylaminoaethanol (German)
Dimethylaminoethanol
DMAE
Kalpur P
Liparon
N,N-Dimethyl-2-hydroxyethylamine
N,N-Dimethylaminoethanol
N,N-Dimethylethanolamine
N,N-Dimethyl-N-(2-hydroxyethyl)amine
N-Dimethylaminoethanol
Norcholine
Propamine A
Texacat DME

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 µL severeVHTODE 38,422,1996
skin /rabbit 445 mg open irritation test mildUCDS** 12/15/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 3250 mg/m3Brain and Coverings: Recordings from specific areas of CNS

Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold
GTPZAB 14(11),52,1970
inhalation/rat lethal concentration (50 percent kill): 1641 ppm/4HEye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
FAATDF 9,512,1987
intraperitoneal/guinea pig lowest published lethal dose: 450 mg/kgPSEBAA 85,642,1954
intraperitoneal/mouse lethal dose (50 percent kill): 234 mg/kgBehavioral: AtaxiaJPETAB 94,249,1948
intraperitoneal/rat lethal dose (50 percent kill): 1080 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 12,486,1968
oral/rat lethal dose (50 percent kill): 2 gm/kgZHYGAM 20,393,1974
skin/rabbit lethal dose (50 percent kill): 1370 µL/kgAMIHBC 4,119,1951
subcutaneous/mouse lethal dose (50 percent kill): 961 mg/kgBehavioral: Tremor

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes
AEPPAE 225,428,1955

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 670 mg/m3/4H/22W- intermittentEndocrine: Changes in adrenal weight

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 14(11),52,1970
inhalation/rat lowest published toxic concentration: 288 ppm/6H/2W- intermittentEye: Corneal damage

Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 9,512,1987
inhalation/rat lowest published toxic concentration: 76 ppm/6H/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFAATDF 9,512,1987
skin/rabbit lowest published toxic dose: 18 mL/kg/11D- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 14,219,1995

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (7.4 mg/m3), short term exposure limit 6 ppm (22 mg/m3), JUL2008
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (7.4 mg/m3); short term exposure limit 6 ppm (22 mg/m3), JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 7.4 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (7.4 mg/m3);short term exposure limit 6 ppm (22 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83678; Number of Industries 44; Total Number of Facilities 1838; Number of Occupations 36; Total Number of Employees Exposed 33474; Total Number of Female Employees Exposed 5559
National Occupational Hazard Survey 1974Hazard Code 83678; Number of Industries 9; Total Number of Facilities 249; Number of Occupations 23; Total Number of Employees Exposed 6372

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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