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Ethanol, 2 - chloro - , phosphate (3:1)

RTECS #: KK2450000

CAS #: 115-96-8


UPDATE: February 2008 MW: 285.50 MF: C6H12Cl3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Chloroethanol phosphate
  2. Antiblaze 100
  3. Celluflex
  4. Fyrol CEF
  5. NCI - C60128
  6. Niax flame retardant 3 CF
  7. Phosphoric acid, tris (2 - chloroethyl) ester
  1. Tri (2 - chloroethyl) phosphate
  2. Tri - beta - chloroethyl phosphate
  3. Trichlorethyl phosphate
  4. Tris (2 - chloroethyl) phosphate
  5. Tris (2 - chloroethyl) phosphate
  6. Tris (beta - chloroethyl) phosphate
  7. Tris - (2 - chlorethyl) fosfat (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 Ámol/plate (-enzymatic activation step) MUREAV 66,373,1979
micronucleus test intraperitoneal
hamster
125 mg/kg EJCODS 18,1337,1982
morphological transform hamster embryo 400 mg/L EJCODS 18,1337,1982
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster lung 700 mg/L EJCODS 18,1337,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 24.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
NTIS** #PB920129170
oral
mouse
lowest published toxic dose: 350 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB920129170
oral
mouse
lowest published toxic dose: 6,125 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB920129170
oral
rat
lowest published toxic dose: 1,800 mg/kg (7-15 day pregnant) Reproductive: Effects on newborn: Behavioral ESKHA5 (101),55,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 182 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-391,1991
oral
mouse
lowest published toxic dose: 182,000 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB92-105147/AS
oral
mouse
lowest published toxic dose: 91,000 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Tumors
NTIS** PB92-105147/AS
oral
rat
lowest published toxic dose: 45,760 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-391,1991
oral
rat
lowest published toxic dose: 45,760 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
NTIS** PB92-105147/AS
oral
rat
lowest published toxic dose: 45,760 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB92-105147/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published lethal dose: 250 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold
CBCCT* 7,396,1955
oral
mouse
lethal dose (50 percent kill): 1,866 mg/kg N/R NTIS** AD-A067-313
oral
rat
lethal dose (50 percent kill): 1,230 mg/kg N/R BECTA6 17,720,1977
skin
rabbit
lowest published lethal dose: 2 gm/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes
NTIS** OTS0517716


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 56 gm/kg/16 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990
oral
mouse
lowest published toxic dose: 56 gm/kg/16 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990
oral
mouse
lowest published toxic dose: 4,900 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB920129170
oral
mouse
lowest published toxic dose: 102,900 mg/kg/21 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** #PB920129170
oral
rat
lowest published toxic dose: 2,100 mg/kg/16 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-391,1991
oral
rat
lowest published toxic dose: 28 gm/kg/16 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1543,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 48,109,1990
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1543,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1543,1999
TOXICOLOGY REVIEW
CTOXAO 17,101,1980
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0756;
Number of Industries 5;
Total Number of Facilities 95;
Number of Occupations 9;
Total Number of Employees Exposed 762
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0756;
Number of Industries 6;
Total Number of Facilities 278;
Number of Occupations 5;
Total Number of Employees Exposed 5,073;
Total Number of Female Employees Exposed 578


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a flame retardant chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse


REFERENCES:

CODEN
REFERENCE

BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-

Used as a flame retardant chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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