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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-chloro-, phosphate (3:1)

RTECS #

KK2450000

CAS #

115-96-8

Updated

March 2011

Molecular Weight

285.50

Molecular Formula

C6H12Cl3O4P

Synonyms

2-Chloroethanol phosphate
Antiblaze 100
Celluflex
Fyrol CEF
NCI-C60128
Niax flame retardant 3 CF
Phosphoric acid, tris(2-chloroethyl)ester
Tri(2-chloroethyl)phosphate
Tri-beta-chloroethyl phosphate
Trichlorethyl phosphate
Tris-(2-chlorethyl)fosfat (Czech)
Tris(2-chloroethyl) phosphate
Tris(2-chloroethyl)phosphate
Tris(beta-chloroethyl) phosphate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/hamster125 mg/kgEJCODS 18,1337,1982
morphological transformembryo/hamster400 mg/LEJCODS 18,1337,1982
morphological transformfibroblast/mouse0.1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (-enzymatic activation step)MUREAV 66,373,1979
sister chromatid exchangelung/hamster700 mg/LEJCODS 18,1337,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1800 mg/kg (7-15D pregnant)Reproductive: Effects on newborn: BehavioralESKHA5 (101),55,1983
oral/mouse 24.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
NTIS** #PB920129170
oral/mouse 350 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB920129170
oral/mouse 6125 mg/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB920129170

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 182 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-391,1991
oral/mouse lowest published toxic dose: 182000 mg/kg/104W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB92-105147/AS
oral/mouse lowest published toxic dose: 91000 mg/kg/104W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Tumors
NTIS** PB92-105147/AS
oral/rat lowest published toxic dose: 45760 mg/kg/104W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
NTIS** PB92-105147/AS
oral/rat lowest published toxic dose: 45760 mg/kg/104W- intermittentTumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB92-105147/AS
oral/rat lowest published toxic dose: 45760 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-391,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 250 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold
CBCCT* 7,396,1955
oral/mouse lethal dose (50 percent kill): 1866 mg/kgNTIS** AD-A067-313
oral/rat lethal dose (50 percent kill): 1230 mg/kgBECTA6 17,720,1977
skin/rabbit lowest published lethal dose: 2 gm/kgEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes
NTIS** OTS0517716

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 56 gm/kg/16W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990
oral/mouse lowest published toxic dose: 56 gm/kg/16W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990
oral/mouse lowest published toxic dose: 4900 mg/kg/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB920129170
oral/mouse lowest published toxic dose: 102900 mg/kg/21W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** #PB920129170
oral/rat lowest published toxic dose: 2100 mg/kg/16D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-391,1991
oral/rat lowest published toxic dose: 28 gm/kg/16W- intermittentBrain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 6,1,1990

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1543,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 48,109,1990
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1543,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1543,1999
TOXICOLOGY REVIEWCTOXAO 17,101,1980
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWNTAPM* -,359,1995

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0756; Number of Industries 6; Total Number of Facilities 278; Number of Occupations 5; Total Number of Employees Exposed 5073; Total Number of Female Employees Exposed 578
National Occupational Hazard Survey 1974Hazard Code M0756; Number of Industries 5; Total Number of Facilities 95; Number of Occupations 9; Total Number of Employees Exposed 762

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
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