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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(2-butoxyethoxy)-

RTECS #

KJ9100000

CAS #

112-34-5

Updated

September 201

Molecular Weight

162.26

Molecular Formula

C8H18O3

Synonyms

2-(2-Butoxyethoxy)ethanol
BUCB
Butoxydiethylene glycol
Butoxydiglycol
Butyl carbitol
Butyl dioxitol
Diethylene glycol monobutyl ether
Diethylene glycol n-butyl ether
Diglycol monobutyl ether
Dowanol DB
Ektasolve DB
Glycol ether DB
Jeffersol DB
O-Butyl diethylene glycol
Poly-Solv DB

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 20 mg/24H moderate85JCAE -,635,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 2596.8 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/rat lowest published toxic concentration: 936 mg/m3/4HBehavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOVEFN (6),42,2002
inhalation/rat lowest published toxic concentration: 936 mg/m3/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOVEFN (6),42,2002
intraperitoneal/mouse lethal dose (50 percent kill): 850 mg/kgLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
FEPRA7 6,342,1947
oral/guinea pig lethal dose (50 percent kill): 2 gm/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lethal dose (50 percent kill): 2000 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral/human lowest published lethal dose: 0.5 mL/kgVCVGK* -,174,1984
oral/mouse lethal dose (50 percent kill): 4500 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (6),42,2002
oral/mouse lethal dose (50 percent kill): 4500 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOVEFN (6),42,2002
oral/mouse lethal dose (50 percent kill): 6050 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral/mouse lethal dose (50 percent kill): 2400 mg/kgJACTDZ 12,139,1993
oral/rabbit lethal dose (50 percent kill): 2200 mg/kg38MKAJ 2C,3964,1982
oral/rat lethal dose (50 percent kill): 4500 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral/rat lethal dose (50 percent kill): 5660 mg/kgDOWCC* MSD-41
oral/rat lethal dose (50 percent kill): 6050 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (6),42,2002
oral/rat lethal dose (50 percent kill): 6050 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOVEFN (6),42,2002
skin/rabbit lethal dose (50 percent kill): 2700 mg/kgJACTDZ 12,139,1993
unreported route/mouse lethal dose (50 percent kill): 6050 mg/kgGISAAA 46(2),14,1981
unreported route/rat lethal dose (50 percent kill): 4500 mg/kgGISAAA 46(2),14,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/24H/17W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 46(2),14,1981
inhalation/rat lowest published toxic concentration: 5 mg/m3/122D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,175,1994
oral/rat lowest published toxic dose: 102375 mg/kg/13W- intermittentBehavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,174,1994
oral/rat lowest published toxic dose: 83 gm/kg/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,164,1986
oral/rat lowest published toxic dose: 109 gm/kg/6W- intermittentBehavioral: Food intake (animal)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570960

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm (inhal, vapor)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (67.5 mg/m3);KZW 15 ppm (101.2 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (67.5 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 15 ppm (101.2 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (67.5 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 67.5 mg/m3 (10 ppm);short term exposure limit 101.2 mg/m3 (15 ppm), FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (68 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (67.5 mg/m3), VLE 15 ppm (101.2 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (67 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (67.5 mg/m3), short term exposure limit 15 ppm (101.2 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 100 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 15 ppm (100 mg/m3);short term exposure limit 30 ppm (200 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (67 mg/m3), KZG-week 15 ppm (101.2 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 50 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (67.5 mg/m3);short term exposure limit 15 ppm (101.2 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80343; Number of Industries 266; Total Number of Facilities 42981; Number of Occupations 158; Total Number of Employees Exposed 641115; Total Number of Female Employees Exposed 173797
National Occupational Hazard Survey 1974Hazard Code 80343; Number of Industries 151; Total Number of Facilities 19782; Number of Occupations 114; Total Number of Employees Exposed 246257

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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