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Ethanol, 2 - (2 - butoxyethoxy) -

RTECS #: KJ9100000

CAS #: 112-34-5


UPDATE: February 2009 MW: 162.26 MF: C8H18O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - (2 - Butoxyethoxy) ethanol
  2. BUCB
  3. Butoxydiethylene glycol
  4. Butoxydiglycol
  5. Butyl carbitol
  6. Butyl dioxitol
  7. Diethylene glycol n - butyl ether
  8. Diethylene glycol monobutyl ether
  1. Diglycol monobutyl ether
  2. Dowanol DB
  3. Ektasolve DB
  4. Glycol ether DB
  5. Jeffersol DB
  6. O - Butyl diethylene glycol
  7. Poly - Solv DB


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
eye
rabbit
20 mg/24 hour moderate 85JCAE -,635,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 936 mg/m3/4 hour Behavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOVEFN (6),42,2002
inhalation
rat
lowest published toxic concentration: 936 mg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOVEFN (6),42,2002
intraperitoneal
mouse
lethal dose (50 percent kill): 850 mg/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
FEPRA7 6,342,1947
oral
guinea pig
lethal dose (50 percent kill): 2 gm/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
guinea pig
lethal dose (50 percent kill): 2,000 mg/kg Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral
human
lowest published lethal dose: 0.5 mL/kg N/R VCVGK* -,174,1984
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg N/R JACTDZ 12,139,1993
oral
mouse
lethal dose (50 percent kill): 6,050 mg/kg Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral
mouse
lethal dose (50 percent kill): 4,500 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (6),42,2002
oral
mouse
lethal dose (50 percent kill): 4,500 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOVEFN (6),42,2002
oral
rat
lethal dose (50 percent kill): 5,660 mg/kg N/R DOWCC* MSD-41
oral
rat
lethal dose (50 percent kill): 4,500 mg/kg Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
VCVGK* -,174,1984
oral
rat
lethal dose (50 percent kill): 6,050 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (6),42,2002
oral
rat
lethal dose (50 percent kill): 6,050 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOVEFN (6),42,2002
oral
rabbit
lethal dose (50 percent kill): 2,200 mg/kg N/R 38MKAJ 2C,3964,1982
skin
rabbit
lethal dose (50 percent kill): 2,700 mg/kg N/R JACTDZ 12,139,1993
unreported route
mouse
lethal dose (50 percent kill): 6,050 mg/kg N/R GISAAA 46(2),14,1981
unreported route
rat
lethal dose (50 percent kill): 4,500 mg/kg N/R GISAAA 46(2),14,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5 mg/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 46(2),14,1981
inhalation
rat
lowest published toxic concentration: 5 mg/m3/122 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,175,1994
oral
rat
lowest published toxic dose: 83 gm/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,164,1986
oral
rat
lowest published toxic dose: 109 gm/kg/6 week- intermittent Behavioral: Food intake (animal)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570960
oral
rat
lowest published toxic dose: 102,375 mg/kg/13 week- intermittent Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,174,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (67.5 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 15 ppm (101.2 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 100 mg/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 67.5 mg/m3 (10 ppm);
short term exposure limit 101.2 mg/m3 (15 ppm), FEB 2006
Occupational Exposure Limit - FRANCE VME 10 ppm (67.5 mg/m3), VLE 15 ppm (101.2 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 100 mg/m3, 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 50 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 15 ppm (100 mg/m3);
short term exposure limit 30 ppm (200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 mg/m3;
KZG- week 100 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80343;
Number of Industries 151;
Total Number of Facilities 19,782;
Number of Occupations 114;
Total Number of Employees Exposed 246,257
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80343;
Number of Industries 266;
Total Number of Facilities 42,981;
Number of Occupations 158;
Total Number of Employees Exposed 641,115;
Total Number of Female Employees Exposed 173,797


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a coalescing agent, solvent, dispersant and diluent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a coalescing agent, solvent, dispersant and diluent

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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