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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1-dichloro-1-fluoro-

RTECS #

KI0997000

CAS #

1717-00-6

Updated

April 2012

Molecular Weight

116.95

Molecular Formula

C2H3Cl2F

Synonyms

1,1-Dichloro-1-fluoroethane
CFC 141b
Freon 141b
HCFC 141b
Isotron 141b
R 141b
Refrigerant 141b
Solkane 141b

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster10 pph/4H-continuousFCTOD7 33,491,1995

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 20000 ppm/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 33,285,1995
inhalation/rat 20000 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathFCTOD7 33,285,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** OTS0538286

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 151 gm/m3/2HBehavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 9(10),37,1965
inhalation/mouse Lowest published lethal concentration: 160 gm/m3/2HPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning
TPKVAL 8,83,1966
inhalation/mouse lethal concentration (50 percent kill): 174 gm/m3/2HBrain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 8,83,1966
inhalation/mouse lowest published toxic concentration: 15 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability
TPKVAL 8,83,1966
inhalation/mouse lethal concentration (50 percent kill): 151400 mg/m3/2HVCVGH* -,632,1990
inhalation/mouse lethal concentration (50 percent kill): 151.4 gm/m3TPKVAL 9,27,1967
inhalation/mouse Lowest published lethal concentration: 199.5 gm/m3/2HKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
TPKVAL 8,83,1966
inhalation/mouse Lowest published lethal concentration: 114.8 gm/m3/2HLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
TPKVAL 8,83,1966
inhalation/rat lethal concentration (50 percent kill): 239.9 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 239900 mg/m3/4HVCVGH* -,632,1990
inhalation/rat lowest published toxic concentration: 15 gm/m3/2HVascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 8,83,1966
inhalation/rat lethal concentration (50 percent kill): 56700 ppm/6HBehavioral: Tremor

Behavioral: Ataxia
FCTOD7 33,483,1995
oral/rat lethal dose (50 percent kill): >5 gm/kgFCTOD7 33,483,1995
skin/rabbit lethal dose (50 percent kill): >2 gm/kgFCTOD7 33,483,1995
skin/rat lethal dose (50 percent kill): >2 gm/kgLiver: Other changesFCTOD7 33,483,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 8.3 gm/m3/45D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTPKVAL 8,83,1966
inhalation/guinea pig lowest published toxic concentration: 18.2 gm/m3/45D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 8,83,1966
inhalation/guinea pig lowest published toxic concentration: 18.2 gm/m3/91D- intermittentBlood: Changes in leukocyte (WBC) countTPKVAL 8,83,1966
inhalation/guinea pig lowest published toxic concentration: 18.2 gm/m3/0.5Y- intermittentBrain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966
inhalation/human lowest published toxic concentration: 1200 mg/m3/4H/9D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionNTIS** OTS0559404
inhalation/mouse lowest published toxic concentration: 18.2 gm/m3/45D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 8,83,1966
inhalation/mouse lowest published toxic concentration: 18.2 gm/m3/91D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 20000 ppm/6H/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)NTIS** OTS0535663
inhalation/rat lowest published toxic concentration: 50 gm/m3/4H/4W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hypofunction
TPKVAL 9,175,1967
inhalation/rat lowest published toxic concentration: 8.3 gm/m3/0.5Y- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hyperfunction
TPKVAL 9,175,1967
inhalation/rat lowest published toxic concentration: 18.2 gm/m3/45D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 18.2 gm/m3/61D- intermittentVascular: BP lowering not characterized in autonomic sectionTPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 8.3 gm/m3/153D- intermittentVascular: BP lowering not characterized in autonomic sectionTPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 8.3 gm/m3/61D- intermittentBehavioral: Alteration of classical conditioningTPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 8.3 gm/m3/76D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesTPKVAL 8,83,1966
inhalation/rat lowest published toxic concentration: 18.2 gm/m3/0.5Y- intermittentBrain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #113
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