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Ethane, 1,1 - dichloro - 1 - fluoro -

RTECS #: KI0997000

CAS #: 1717-00-6


UPDATE: February 2008 MW: 116.95 MF: C2H3Cl2F


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dichloro - 1 - fluoroethane
  2. CFC 141b
  3. Freon 141b
  4. HCFC 141b
  1. Isotron 141b
  2. R 141b
  3. Refrigerant 141b
  4. Solkane 141b


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 10 pph/4 hour- continuous FCTOD7 33,491,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 33,285,1995
inhalation
rat
lowest published toxic concentration: 20,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death FCTOD7 33,285,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** OTS0538286


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 151 gm/m3/2 hour Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 9(10),37,1965
inhalation
mouse
lethal concentration (50 percent kill): 151,400 mg/m3/2 hour N/R VCVGH* -,632,1990
inhalation
mouse
lowest published lethal concentration: 160 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning
TPKVAL 8,83,1966
inhalation
mouse
lethal concentration (50 percent kill): 174 gm/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 8,83,1966
inhalation
mouse
lethal concentration : 114.8 gm/m3/2 hour Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
TPKVAL 8,83,1966
inhalation
mouse
lethal concentration : 199.5 gm/m3/2 hour Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
TPKVAL 8,83,1966
inhalation
mouse
lowest published toxic concentration: 15 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability
TPKVAL 8,83,1966
inhalation
mouse
lethal concentration (50 percent kill): 151.4 gm/m3 N/R TPKVAL 9,27,1967
inhalation
rat
lethal concentration (50 percent kill): 56,700 ppm/6 hour Behavioral: Tremor

Behavioral: Ataxia
FCTOD7 33,483,1995
inhalation
rat
lethal concentration (50 percent kill): 239,900 mg/m3/4 hour N/R VCVGH* -,632,1990
inhalation
rat
lowest published toxic concentration: 15 gm/m3/2 hour Vascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 8,83,1966
inhalation
rat
lethal concentration (50 percent kill): 239.9 gm/m3 N/R TPKVAL 9,27,1967
oral
rat
lethal dose (50 percent kill): >5 gm/kg N/R FCTOD7 33,483,1995
skin
rat
lethal dose (50 percent kill): >2 gm/kg Liver: Other changes FCTOD7 33,483,1995
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R FCTOD7 33,483,1995


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 8.3 gm/m3/45 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 8,83,1966
inhalation
guinea pig
lowest published toxic concentration: 18.2 gm/m3/45 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 8,83,1966
inhalation
guinea pig
lowest published toxic concentration: 18.2 gm/m3/91 day- intermittent Blood: Changes in leukocyte (WBC) count TPKVAL 8,83,1966
inhalation
guinea pig
lowest published toxic concentration: 18.2 gm/m3/0.5 year- intermittent Brain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966
inhalation
human
lowest published toxic concentration: 1,200 mg/m3/4 hour/9 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition NTIS** OTS0559404
inhalation
mouse
lowest published toxic concentration: 18.2 gm/m3/45 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 8,83,1966
inhalation
mouse
lowest published toxic concentration: 18.2 gm/m3/91 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 20,000 ppm/6 hour/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) NTIS** OTS0535663
inhalation
rat
lowest published toxic concentration: 50 gm/m3/4 hour/4 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hypofunction
TPKVAL 9,175,1967
inhalation
rat
lowest published toxic concentration: 8.3 gm/m3/0.5 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Alteration of classical conditioning

Endocrine: Evidence of thyroid hyperfunction
TPKVAL 9,175,1967
inhalation
rat
lowest published toxic concentration: 18.2 gm/m3/45 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 18.2 gm/m3/61 day- intermittent Vascular: BP lowering not characterized in autonomic section TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 8.3 gm/m3/153 day- intermittent Vascular: BP lowering not characterized in autonomic section TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 8.3 gm/m3/61 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 8.3 gm/m3/76 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TPKVAL 8,83,1966
inhalation
rat
lowest published toxic concentration: 18.2 gm/m3/0.5 year- intermittent Brain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 8,83,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #113


REFERENCES:

CODEN
REFERENCE

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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