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Ethane, 1,1' - oxybis -

RTECS #: KI5775000

CAS #: 60-29-7


UPDATE: May 2009 MW: 74.14 MF: C4H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aether
  2. Anaesthetic ether
  3. Anesthesia ether
  4. Anesthetic ether
  5. Diaethylaether (German)
  6. Diethyl ether (DOT:OSHA)
  7. Diethyl oxide
  8. Dwuetylowy eter (Polish)
  9. Etere etilico (Italian)
  1. Ether
  2. Ether ethylique (French)
  3. Ethoxyethane
  4. Ethyl ether
  5. Ethyl ether (ACGIH:OSHA)
  6. Oxyde d'ethyle (French)
  7. RCRA waste number U117
  8. Solvent ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
100 ppm N/R JIHTAB 25,282,1943
eye
rabbit
100 mg moderate FEPRA7 35,729,1976
skin
guinea pig
50 mg/24 hour severe HIFUAG 22,373,1980
skin
rabbit
360 mg open irritation test mild UCDS** 4/5/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition mouse embryo 2,850 mg/L JJATDK 5,1,1985
DNA repair Escherichia coli 35,670 g/well/16 hour CBINA8 15,219,1976
other mutation test systems hamster fibroblast 1 pph ANESAV 43,21,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 76,000 ppm N/R HBAMAK 4,1294,1935
inhalation
human
lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects JIHTAB 25,282,1943
inhalation
human
lowest published toxic concentration: 600 mg/m3/3 minute Lung, Thorax, or Respiration: Cough VCVGK* -,264,1994
inhalation
human
lowest published toxic concentration: 100,000 mg/m3/30 minute Behavioral: General anesthetic VCVGK* -,264,1994
inhalation
mouse
lethal concentration (50 percent kill): 31,000 ppm/30 minute Behavioral: Convulsions or effect on seizure threshold JIDOAA 34,379,1985
inhalation
mouse
lowest published toxic concentration: 24,434 ppm/30 minute Behavioral: Alteration of classical conditioning TXAPA9 193,9,2003
inhalation
mouse
lowest published toxic concentration: 30,000 ppm/30 minute Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
TXAPA9 193,9,2003
inhalation
mouse
lethal concentration (50 percent kill): 31,000 ppm/30 minute N/R ENTOX* -,33,2005
inhalation
rat
lowest published lethal concentration: 32,000 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rat
lowest published toxic concentration: 7 pph Nutritional and Gross Metabolic: Body temperature decrease FATOAO 47,21,1984
inhalation
rabbit
lowest published lethal concentration: 106,000 ppm N/R HBAMAK 4,1294,1935
inhalation
rabbit
lowest published toxic concentration: 10,000 mg/m3/40 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGK* -,264,1994
intraperitoneal
guinea pig
lowest published lethal dose: 2 gm/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases AIHAAP 35,21,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 2.4 gm/kg N/R ENTOX* -,33,2005
intravenous
mouse
lethal dose (50 percent kill): 996 mg/kg N/R ENTOX* -,33,2005
oral
man
lowest published lethal dose: 260 mg/kg N/R 85DCAI 2,73,1970
oral
mouse
lethal dose (50 percent kill): 1,760 mg/kg N/R VCVGK* -,264,1994
oral
rat
lethal dose (50 percent kill): 1,215 mg/kg N/R TXAPA9 19,699,1971
subcutaneous
frog
lowest published lethal dose: 24 gm/kg N/R HBAMAK 4,1295,1935
subcutaneous
mouse
lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1295,1935
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 1 pph/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ANESAV 42,408,1975
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/24 hour/5 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANESAV 42,408,1975
oral
guinea pig
lowest published toxic dose: 760 mg/kg/152 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,265,1994
oral
guinea pig
lowest published toxic dose: 7,600 mg/kg/152 day- intermittent Gastrointestinal: Gastritis VCVGK* -,265,1994
oral
rat
lowest published toxic dose: 760 mg/kg/152 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,265,1994
oral
rat
lowest published toxic dose: 7,600 mg/kg/152 day- intermittent Gastrointestinal: Gastritis VCVGK* -,265,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm;short term exposure limit 500 ppm DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMSUDL 7,93,1987
TOXICOLOGY REVIEW
TOLED5 140-141,249,2003
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,33,2005
TOXICOLOGY REVIEW
HUTOX* -,493,1996
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 400 ppm (1200 mg/m3) DTLVS* 3,106,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1210 mg/m3), short term exposure limit 500 ppm (1520 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm(308 mg/m3), short term exposure limit 200 ppm(616 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (303 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 308 mg/m3 (100 ppm);
short term exposure limit 616 mg/m3 (200 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 400 ppm (1200 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (308 mg/m3), VLE 200 ppm (616 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1200 mg/m3 (400 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 308 mg/m3, short term exposure limit 616 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 400 ppm (1200 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 400 ppm (1200 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 400 ppm (1200 mg/m3);
short term exposure limit 500 ppm (1500 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 308 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 400 ppm (1210 mg/m3);
short term exposure limit 500 ppm (1520 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 200 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1500 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 mg/m3, short term exposure limit 900 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 300 ppm (900 mg/m3);
short term exposure limit 400 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1200 mg/m3),KZG- week 400 ppm (1200 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (310 mg/m3);
short term exposure limit 200 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 400 ppm;
short term exposure limit 500 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 400 ppm;
short term exposure limit 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32590;
Number of Industries 112;
Total Number of Facilities 17,282;
Number of Occupations 82;
Total Number of Employees Exposed 161,572
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32590;
Number of Industries 104;
Total Number of Facilities 21,212;
Number of Occupations 78;
Total Number of Employees Exposed 272,746;
Total Number of Female Employees Exposed 35,683


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl ether, 1610


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HIFUAG Hifu. Skin. (Nippon Hifuka Gakkai Osaka Chihokai, c/o Osaka Daigaku Igakubu, 1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan) V.1- 1959-
HUTOX*
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.1- 1952-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

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