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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,2-dimethoxy-

RTECS #

KI1451000

CAS #

110-71-4

Updated

August 2009

Molecular Weight

90.14

Molecular Formula

C4H10O2

Synonyms

2,5-Dioxahexane
alpha,beta-Dimethoxyethane
Dimethoxyethane
Dimethylcellosolve
Egdme
Ethylene dimethyl ether
Ethylene glycol dimethyl ether
Glycol dimethyl ether
Glyme
Monoethylene glycol dimethyl ether
Monoglyme

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 660 mg/kg (8-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
REPTED 5,157,1991
oral/rat 660 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 5,157,1991
oral/rat 660 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)REPTED 5,157,1991
oral/mouse 1960 mg/kg (7-10D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NISFAY 32,113,1980
oral/mouse 1400 mg/kg (7-10D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemNISFAY 32,113,1980
oral/mouse 361 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 35,321,1987
oral/mouse 16 gm/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EVHPAZ 57,141,1984
oral/mouse 16000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)EVHPAZ 57,141,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 63 gm/m3/6HBehavioral: Somnolence (general depressed activity)

Behavioral: Irritability
NTIS** OTS0571323
inhalation/rat lethal concentration (50 percent kill): >20000 mg/m3/6HBehavioral: AtaxiaHPV004 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kgHPV004 -,-,2001
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kgHPV004 -,-,2001
oral/mouse lethal dose (50 percent kill): 3200 mg/kgHPV004 -,-,2001
oral/rabbit lethal dose (16 percent kill): 160 mg/kgVCVGK* -,319,1984
oral/rabbit lethal dose (50 percent kill): 320 mg/kgVCVGK* -,319,1984
oral/rabbit lethal dose (84 percent kill): 520 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (16 percent kill): 310 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (50 percent kill): 775 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (84 percent kill): 1140 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (50 percent kill): >4000 mg/kgBehavioral: Somnolence (general depressed activity)HPV004 -,-,2001
oral/rat lowest published lethal dose: 1 gm/kgNTIS** OTS0539769
skin/guinea pig lethal dose (50 percent kill): 5 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationHPV004 -,-,2001
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgHPV004 -,-,2001
skin/rabbit lowest published lethal dose: 2 gm/kgNTIS** OTS0539769

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4000 ppm/4H/2W- intermittentBehavioral: Change in psychophysiological tests

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 25,369,1964
inhalation/rat lowest published toxic concentration: 18000 mg/m3/4H/5D- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
oral/mouse lowest published toxic dose: 16000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83728; Number of Industries 4; Total Number of Facilities 94; Number of Occupations 7; Total Number of Employees Exposed 3319; Total Number of Female Employees Exposed 1003
National Occupational Hazard Survey 1974Hazard Code 83728; Number of Industries 3; Total Number of Facilities 68; Number of Occupations 2; Total Number of Employees Exposed 265

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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