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Ethane, 1,2 - dimethoxy -

RTECS #: KI1451000

CAS #: 110-71-4


UPDATE: February 2006 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,5 - Dioxahexane
  2. Dimethoxyethane
  3. Dimethylcellosolve
  4. Egdme
  5. Ethylene dimethyl ether
  6. Ethylene glycol dimethyl ether
  1. Glycol dimethyl ether
  2. Glyme
  3. Monoethylene glycol dimethyl ether
  4. Monoglyme
  5. alpha,beta - Dimethoxyethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,960 mg/kg (7-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NISFAY 32,113,1980
oral
mouse
lowest published toxic dose: 1,400 mg/kg (7-10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NISFAY 32,113,1980
oral
mouse
lowest published toxic dose: 361 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 35,321,1987
oral
mouse
lowest published toxic dose: 16 gm/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 16,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
rat
lowest published toxic dose: 660 mg/kg (8-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
REPTED 5,157,1991
oral
rat
lowest published toxic dose: 660 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 5,157,1991
oral
rat
lowest published toxic dose: 660 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 5,157,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 63 gm/m3/6 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Irritability
NTIS** OTS0571323
intraperitoneal
mouse
lethal dose (50 percent kill): 400 mg/kg N/R NTIS** OTS0571323
intraperitoneal
rat
lethal dose (50 percent kill): 800 mg/kg N/R NTIS** OTS0571323
oral
mouse
lethal dose (50 percent kill): 3,200 mg/kg N/R NTIS** OTS0571323
oral
rat
lowest published lethal dose: 1 gm/kg N/R NTIS** OTS0539769
oral
rat
lethal dose (16 percent kill): 310 mg/kg N/R VCVGK* -,319,1984
oral
rat
lethal dose (50 percent kill): 775 mg/kg N/R VCVGK* -,319,1984
oral
rat
lethal dose (84 percent kill): 1,140 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (16 percent kill): 160 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (50 percent kill): 320 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (84 percent kill): 520 mg/kg N/R VCVGK* -,319,1984
skin
rabbit
lowest published lethal dose: 2 gm/kg N/R NTIS** OTS0539769


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4,000 ppm/4 hour/2 week- intermittent Behavioral: Change in psychophysiological tests

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 25,369,1964
inhalation
rat
lowest published toxic concentration: 18,000 mg/m3/4 hour/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
oral
mouse
lowest published toxic dose: 16,000 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83728;
Number of Industries 3;
Total Number of Facilities 68;
Number of Occupations 2;
Total Number of Employees Exposed 265
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83728;
Number of Industries 4;
Total Number of Facilities 94;
Number of Occupations 7;
Total Number of Employees Exposed 3,319;
Total Number of Female Employees Exposed 1,003


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and to facilitate formation of alkali metal-hydrocarbon adducts
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent and to facilitate formation of alkali metal-hydrocarbon adducts

RTECS Compound Description:
   Reproductive Effector

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