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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,2-diethoxy-

RTECS #

KI1225000

CAS #

629-14-1

Updated

August 2008

Molecular Weight

118.20

Molecular Formula

C6H14O2

Synonyms

1,2-Diethoxyethane
Diethyl cellosolve
Diethylether ethylenglykolu (Czech)
Ethyl glyme
Ethylene glycol diethyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAJOPAA 29,1363,1946

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 23640 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EVHPAZ 57,141,1984
oral/mouse 23640 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral/mouse 5000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB88-134093
oral/rabbit 1400 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 19,15,1992
oral/rabbit 1.4 gm/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
NTIS** #PB88-157516/AS
oral/mouse 1.5 gm/kg (6-15D pregnant)Reproductive: Other developmental abnormalitiesNTIS** #PB88-134093
oral/mouse 5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)NTIS** #PB88-134093
oral/mouse 10 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** #PB88-134093

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 50000 mg/m3/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
inhalation/guinea pig lowest published toxic concentration: 50000 mg/m3/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
inhalation/rabbit lowest published toxic concentration: 50000 mg/m3/1HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HJIHTAB 31,343,1949
oral/guinea pig lethal dose (50 percent kill): 2440 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/rabbit lethal dose (16 percent kill): 760 mg/kgVCVGK* -,319,1984
oral/rabbit lethal dose (50 percent kill): 1275 mg/kgVCVGK* -,319,1984
oral/rabbit lethal dose (84 percent kill): 1580 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (16 percent kill): 840 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (50 percent kill): 2350 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (84 percent kill): 3570 mg/kgVCVGK* -,319,1984
oral/rat lethal dose (50 percent kill): 4390 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
inhalation/rabbit lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
oral/mouse lowest published toxic dose: 10000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB88-134093
oral/rabbit lowest published toxic dose: 1400 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB89-165849

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 25,192,2008

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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