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Ethane, 1,2 - diethoxy -

RTECS #: KI1225000

CAS #: 629-14-1


UPDATE: August 2008 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2 - Diethoxyethane
  2. Diethyl cellosolve
  3. Diethylether ethylenglykolu (Czech)
  1. Ethyl glyme
  2. Ethylene glycol diethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 23,640 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 23,640 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral
mouse
lowest published toxic dose: 5,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB88-134093
oral
mouse
lowest published toxic dose: 1.5 gm/kg (6-15 day pregnant) Reproductive: Other developmental abnormalities NTIS** #PB88-134093
oral
mouse
lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) NTIS** #PB88-134093
oral
mouse
lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** #PB88-134093
oral
rabbit
lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 19,15,1992
oral
rabbit
lowest published toxic dose: 1.4 gm/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
NTIS** #PB88-157516/AS


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 50,000 mg/m3/1 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
inhalation
guinea pig
lowest published toxic concentration: 50,000 mg/m3/1 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rabbit
lowest published toxic concentration: 50,000 mg/m3/1 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
oral
guinea pig
lethal dose (50 percent kill): 2,440 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
rat
lethal dose (50 percent kill): 4,390 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
rat
lethal dose (16 percent kill): 840 mg/kg N/R VCVGK* -,319,1984
oral
rat
lethal dose (50 percent kill): 2,350 mg/kg N/R VCVGK* -,319,1984
oral
rat
lethal dose (84 percent kill): 3,570 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (16 percent kill): 760 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (50 percent kill): 1,275 mg/kg N/R VCVGK* -,319,1984
oral
rabbit
lethal dose (84 percent kill): 1,580 mg/kg N/R VCVGK* -,319,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
inhalation
rabbit
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
oral
mouse
lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB88-134093
oral
rabbit
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB89-165849


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as aprotic solvent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as aprotic solvent

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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