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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 2,2-dichloro-1,1,1-trifluoro-

RTECS #

KI1108000

CAS #

306-83-2

Updated

December 2012

Molecular Weight

152.93

Molecular Formula

C2HCl2F3

Synonyms

1,1,1-Trifluoro-2,2-dichloroethane
2,2-Dichloro-1,1,1-trifluoroethane
CFC-123
Chlorofluorocarbon 123
Dichloro(trifluoromethyl)methane
FC 123
Freon 123
HCFC 123
HFA 123
Hydrochlorofluorocarbon
R 123
Refrigerant HCFC-123
Refrigerant R 123
Solkane 123

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL mildNTIS** OTS0530607
eye /rabbit 0.1 mL moderateHPV223 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human50 ppm/24H (-enzymatic activation step)NTIS** OTS0530498-1
Cytogenetic Analysislymphocyte/human30 pph/3H (+enzymatic activation step)NTIS** OTS0530498-1

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 300 ppm/6H (4W male/4W pre-7W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 34,276,1996
inhalation/rat 1000 ppm/6H (22W male)Reproductive: Other effects on maleNTIS** OTS0557691
inhalation/rabbit 500 ppm/6H (6-18D pregnant)Reproductive: Other effects on femaleTJADAB 51,196,1996

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** OTS0530498-3
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** OTS0543416
inhalation/rat lowest published toxic concentration: 5000 ppm/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV223 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 19500 ppm/5MBehavioral: Somnolence (general depressed activity)

Cardiac: Arrythmias (indlucing changes in conduction)
HPV223 -,-,2001
inhalation/Dog lowest published toxic concentration: 1000 ppm/5MBehavioral: Alteration of classical conditioningTOVEFN (4),45,2007
inhalation/guinea pig lowest published toxic concentration: 5000 ppm/4HLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Liver function tests impaired
ARTODN 75,274,2001
inhalation/mouse lowest published toxic concentration: 451500 mg/m3/1HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
VCVGH* -,635,1990
inhalation/mouse lethal concentration (50 percent kill): 74000 ppm/1HBJANAD 37,716,1965
inhalation/rat lethal concentration (50 percent kill): 32000 ppm/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0530611
inhalation/rat lethal concentration (50 percent kill): 225700 mg/m3/4HVCVGH* -,635,1990
inhalation/rat lowest published toxic concentration: 1000 ppm/4HLiver: Liver function tests impairedTOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 5000 ppm/4HBehavioral: Alteration of classical conditioningTOVEFN (4),45,2007
inhalation/rat lethal concentration (50 percent kill): 28400 ppm/4HBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage
TOVEFN (4),45,2007
inhalation/rat lethal concentration (50 percent kill): 32000 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV223 -,-,2001
intraperitoneal/guinea pig lowest published toxic dose: 153 mg/kgLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 144,35,2003
intraperitoneal/guinea pig lowest published toxic dose: 1529 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 144,35,2003
intraperitoneal/guinea pig lowest published toxic dose: 153 mg/kgLiver: Liver function tests impaired

Liver: Other changes
TOXID9 1,87,2001
oral/rat lowest published lethal dose: 9000 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV223 -,-,2001
oral/rat lowest published lethal dose: 9 gm/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0530608
skin/rabbit lethal dose (50 percent kill): >2 gm/kgNTIS** OTS0530597
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV223 -,-,2001
skin/rat lethal dose (50 percent kill): >2000 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV223 -,-,2001
skin/rat lethal dose (50 percent kill): >2000 mg/kgTOVEFN (4),45,2007

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 10000 ppm/6H/13W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0530613
inhalation/Dog lowest published toxic concentration: 1000 ppm/5D- intermittentLiver: Other changesTOVEFN (4),45,2007
inhalation/Dog lowest published toxic concentration: 188 mg/m3/2W- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN (4),45,2007
inhalation/guinea pig lowest published toxic concentration: 100 ppm/4W- intermittentLiver: Fatty liver degeneration

Liver: Liver function tests impaired
TOVEFN (4),45,2007
inhalation/guinea pig lowest published toxic concentration: 5000 ppm/4H/5D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Liver function tests impaired
ARTODN 75,274,2001
inhalation/guinea pig lowest published toxic concentration: 5000 ppm/3W- intermittentLiver: Fatty liver degeneration

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 76,707,2002
inhalation/guinea pig lowest published toxic concentration: 188 mg/m3/2W- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN (4),45,2007
inhalation/monkey lowest published toxic concentration: 188 mg/m3/2W- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN (4),45,2007
inhalation/rabbit lowest published toxic concentration: 500 ppm/13D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TJADAB 51,196,1995
inhalation/rat lowest published toxic concentration: 5200 ppm/14D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight
TOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 100 ppm/14D- intermittentEndocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 1000 ppm/2Y- intermittentGastrointestinal: Changes in structure or function of exocrine pancreasTOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 188 mg/m3/2W- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 300 ppm/2Y- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV223 -,-,2001
inhalation/rat lowest published toxic concentration: 5000 ppm/2Y- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV223 -,-,2001
inhalation/rat lowest published toxic concentration: 300 ppm/5D- intermittentLiver: Other changesTOVEFN (4),45,2007
inhalation/rat lowest published toxic concentration: 300 ppm/6H/13W- intermittentLiver: Other changes

Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0530615
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/90D- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0528777
inhalation/rat lowest published toxic concentration: 10000 ppm/6H/4W- intermittentBehavioral: General anesthetic

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0530616
inhalation/rat lowest published toxic concentration: 300 ppm/6H/2Y- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0543416

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (63 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (62 mg/m3), MAY2012

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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